Reading and writing of mRNA m6A modification orchestrate maternal-to-zygotic transition in mice

Reading and writing of mRNA m6A modification orchestrate maternal-to-zygotic transition in mice

Abstract N6-methyladenosine (m6A) modification has been shown to regulate RNA metabolism. Here, we investigate m6A dynamics during maternal-to-zygotic transition (MZT) in mice through multi-omic analysis. Our results show that m6A can be maternally inherited or de novo gained after fertilization. In...

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Bibliographic Details
Main Authors: Wencheng Zhu, Yufeng Ding, Juan Meng, Lei Gu, Wenjun Liu, Li Li, Hongyu Chen, Yining Wang, Ziyi Li, Chen Li, Yidi Sun, Zhen Liu
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Genome Biology
Subjects:
m6A landscape
Multi-omics
Maternal-to-zygotic transition
Ythdc1
Ythdf2
Online Access:https://doi.org/10.1186/s13059-023-02918-9

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