Diabetes mellitus: Preventive and curative therapies with aqueous extract of Rytigynia senegalensis Blume (Rubiaceae) in Wistar rats
Background and aim: African traditional healers use Rytigynia senegalensis Blume to treat diseases such as diabetes mellitus, malaria, dysentery, constipation, and hemorrhoids. This study aimed to assess the hypoglycemic, lipid-lowering, and antioxidant properties of R. senegalensis extract (AERS) i...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-07-01
|
| Series: | Journal of Traditional and Complementary Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2225411023000263 |
| _version_ | 1797802769431658496 |
|---|---|
| author | Barthelemy Maidadi Fidèle Ntchapda David Miaffo Abba Talba Mahamad |
| author_facet | Barthelemy Maidadi Fidèle Ntchapda David Miaffo Abba Talba Mahamad |
| author_sort | Barthelemy Maidadi |
| collection | DOAJ |
| description | Background and aim: African traditional healers use Rytigynia senegalensis Blume to treat diseases such as diabetes mellitus, malaria, dysentery, constipation, and hemorrhoids. This study aimed to assess the hypoglycemic, lipid-lowering, and antioxidant properties of R. senegalensis extract (AERS) in type 1 diabetic (T1D) and insulin-resistant (T2D) rats. Experimental procedure: The induction of T1D was made by intraperitoneal administration of streptozotocin (55 mg/kg b.w). As for T2D, it was induced for 10 days by daily subcutaneous administration of dexamethasone (1 mg/kg b.w). Diabetic animals were divided and treated with AERS (50, 100, and 200 mg/kg b.w) for 28 and 10 days for T1D and T2D, respectively. Glycaemia, food and water consumption, relative body weight, insulinemia, lipid profile, and oxidative stress parameters were evaluated. Histological sections were made on the pancreas of T1D rats. Results and conclusion: AERS (100 and/or 200 mg/kg) prevented (p < 0.05 to p < 0.001) weight loss, polyphagia, and polysipsia in diabetic rats. AERS significantly lowered (p < 0.05 to p < 0.001) insulinemia, hyperglycemia, triglycerides (TG), low-density lipoprotein cholesterol (LDL-c) total cholesterol (TC),and malondialdehyde (MDA). In contrast, a significant increase (p < 0.05 to p < 0.001) in high-density lipoprotein cholesterol (HDL-c) levels, reduced glutathione levels, and superoxide dismutase (SOD) and catalase (CAT) activities were observed with all doses of AERS. Histopathological analysis showed an increase in the number and size of islets of Langerhans in the pancreas of T1D rats receiving AERS. AERS has an important antidiabetic, antidyslipidemic, and antioxidant potential. |
| first_indexed | 2024-03-13T05:11:46Z |
| format | Article |
| id | doaj.art-28179b2df46c45acb7267874373224ad |
| institution | Directory Open Access Journal |
| issn | 2225-4110 |
| language | English |
| last_indexed | 2024-03-13T05:11:46Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Traditional and Complementary Medicine |
| spelling | doaj.art-28179b2df46c45acb7267874373224ad2023-06-16T05:09:54ZengElsevierJournal of Traditional and Complementary Medicine2225-41102023-07-01134358367Diabetes mellitus: Preventive and curative therapies with aqueous extract of Rytigynia senegalensis Blume (Rubiaceae) in Wistar ratsBarthelemy Maidadi0Fidèle Ntchapda1David Miaffo2Abba Talba Mahamad3Laboratory of Animal Physiology and Pharmacognosy, Department of Biological Sciences, Faculty of Sciences, University of Maroua, P.O. Box 814, Maroua, CameroonLaboratory of Medicinal Plants, Health and Galenic Formulation, Department of Biological Sciences, Faculty of Sciences, University of Ngaoundere, P.O. Box 454, Ngaoundere, CameroonLaboratory of Life and Earth Sciences, Department of Life and Earth Sciences, Higher Teachers' Training College, University of Maroua, P.O. Box 55, Maroua, Cameroon; Corresponding author. Department of Life and Earth Sciences, Higher Teachers' Training College, University of Maroua, Cameroon.Laboratory of Animal Physiology and Pharmacognosy, Department of Biological Sciences, Faculty of Sciences, University of Maroua, P.O. Box 814, Maroua, CameroonBackground and aim: African traditional healers use Rytigynia senegalensis Blume to treat diseases such as diabetes mellitus, malaria, dysentery, constipation, and hemorrhoids. This study aimed to assess the hypoglycemic, lipid-lowering, and antioxidant properties of R. senegalensis extract (AERS) in type 1 diabetic (T1D) and insulin-resistant (T2D) rats. Experimental procedure: The induction of T1D was made by intraperitoneal administration of streptozotocin (55 mg/kg b.w). As for T2D, it was induced for 10 days by daily subcutaneous administration of dexamethasone (1 mg/kg b.w). Diabetic animals were divided and treated with AERS (50, 100, and 200 mg/kg b.w) for 28 and 10 days for T1D and T2D, respectively. Glycaemia, food and water consumption, relative body weight, insulinemia, lipid profile, and oxidative stress parameters were evaluated. Histological sections were made on the pancreas of T1D rats. Results and conclusion: AERS (100 and/or 200 mg/kg) prevented (p < 0.05 to p < 0.001) weight loss, polyphagia, and polysipsia in diabetic rats. AERS significantly lowered (p < 0.05 to p < 0.001) insulinemia, hyperglycemia, triglycerides (TG), low-density lipoprotein cholesterol (LDL-c) total cholesterol (TC),and malondialdehyde (MDA). In contrast, a significant increase (p < 0.05 to p < 0.001) in high-density lipoprotein cholesterol (HDL-c) levels, reduced glutathione levels, and superoxide dismutase (SOD) and catalase (CAT) activities were observed with all doses of AERS. Histopathological analysis showed an increase in the number and size of islets of Langerhans in the pancreas of T1D rats receiving AERS. AERS has an important antidiabetic, antidyslipidemic, and antioxidant potential.http://www.sciencedirect.com/science/article/pii/S2225411023000263Diabetes mellitusRytigynia senegalensisStreptozotocinLipid profileAntioxidant |
| spellingShingle | Barthelemy Maidadi Fidèle Ntchapda David Miaffo Abba Talba Mahamad Diabetes mellitus: Preventive and curative therapies with aqueous extract of Rytigynia senegalensis Blume (Rubiaceae) in Wistar rats Journal of Traditional and Complementary Medicine Diabetes mellitus Rytigynia senegalensis Streptozotocin Lipid profile Antioxidant |
| title | Diabetes mellitus: Preventive and curative therapies with aqueous extract of Rytigynia senegalensis Blume (Rubiaceae) in Wistar rats |
| title_full | Diabetes mellitus: Preventive and curative therapies with aqueous extract of Rytigynia senegalensis Blume (Rubiaceae) in Wistar rats |
| title_fullStr | Diabetes mellitus: Preventive and curative therapies with aqueous extract of Rytigynia senegalensis Blume (Rubiaceae) in Wistar rats |
| title_full_unstemmed | Diabetes mellitus: Preventive and curative therapies with aqueous extract of Rytigynia senegalensis Blume (Rubiaceae) in Wistar rats |
| title_short | Diabetes mellitus: Preventive and curative therapies with aqueous extract of Rytigynia senegalensis Blume (Rubiaceae) in Wistar rats |
| title_sort | diabetes mellitus preventive and curative therapies with aqueous extract of rytigynia senegalensis blume rubiaceae in wistar rats |
| topic | Diabetes mellitus Rytigynia senegalensis Streptozotocin Lipid profile Antioxidant |
| url | http://www.sciencedirect.com/science/article/pii/S2225411023000263 |
| work_keys_str_mv | AT barthelemymaidadi diabetesmellituspreventiveandcurativetherapieswithaqueousextractofrytigyniasenegalensisblumerubiaceaeinwistarrats AT fidelentchapda diabetesmellituspreventiveandcurativetherapieswithaqueousextractofrytigyniasenegalensisblumerubiaceaeinwistarrats AT davidmiaffo diabetesmellituspreventiveandcurativetherapieswithaqueousextractofrytigyniasenegalensisblumerubiaceaeinwistarrats AT abbatalbamahamad diabetesmellituspreventiveandcurativetherapieswithaqueousextractofrytigyniasenegalensisblumerubiaceaeinwistarrats |