BIOMARKERS OF MYOCARDIAL STRESS AND FIBROSIS FOR CLINICAL OUTCOMES ASSESSMENT IN POST MYOCARDIAL INFARCTION HEART FAILURE PATIENTS
Aim. To assess the prognostic significance of the ST2 and N-terminal pre-brain natriuretic peptide (NT-proBNP) in patients with chronic heart failure (CHF) of ischemic origin.Material and methods. The study included 127 patients with CHF, post myocardial infarction (age median 57 y. o., left ventric...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2018-03-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/2520 |
| Summary: | Aim. To assess the prognostic significance of the ST2 and N-terminal pre-brain natriuretic peptide (NT-proBNP) in patients with chronic heart failure (CHF) of ischemic origin.Material and methods. The study included 127 patients with CHF, post myocardial infarction (age median 57 y. o., left ventricle ejection fraction — 54%), consequently admitted at Clinic. The biomarker concentrations representing myocardial stress (NT-proBNP) and fibrosis with remodeling of the ventricles (ST2) were measured with the immune enzyme assay. Endpoint was all-cause mortality and repeat hospitalizations during 9-month follow-up.Results. Levels of ST2 and NT-proBNP were higher in adverse outcome patients (n=19) comparing to the patients with no repeat cardiovascular events (р=0,004 and 0,001, respectively). Receiver operating characteristic (ROC) analysis for outcomes prediction defined the optimal threshold values of 43,6 ng/mL for ST2 and 285 pg/mL for NT-proBNP. In comparison of ROC-curves, biomarkers had comparable areas under the curves (p=0,659). In binary regression model, statistically significant predictors for combination endpoint were ST2, NT-proBNP and traditional risk factors (class by New York Heart Association, left ventricle aneurysm, stroke anamnesis, estimated glomerular filtration rate <90 mL/min/1,73 m2). The model had the under-curve-area 0,900 (p<0,001).Conclusion. ST2 and NT-proBNP are significant predictors of adverse clinical outcomes in CHF patients post myocardial infarction. |
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| ISSN: | 1560-4071 2618-7620 |