BIOMARKERS OF MYOCARDIAL STRESS AND FIBROSIS FOR CLINICAL OUTCOMES ASSESSMENT IN POST MYOCARDIAL INFARCTION HEART FAILURE PATIENTS
Aim. To assess the prognostic significance of the ST2 and N-terminal pre-brain natriuretic peptide (NT-proBNP) in patients with chronic heart failure (CHF) of ischemic origin.Material and methods. The study included 127 patients with CHF, post myocardial infarction (age median 57 y. o., left ventric...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2018-03-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/2520 |
| _version_ | 1797856869383929856 |
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| author | N V Shilyaeva Y V Shchukin L V Limareva O P Danilchenko |
| author_facet | N V Shilyaeva Y V Shchukin L V Limareva O P Danilchenko |
| author_sort | N V Shilyaeva |
| collection | DOAJ |
| description | Aim. To assess the prognostic significance of the ST2 and N-terminal pre-brain natriuretic peptide (NT-proBNP) in patients with chronic heart failure (CHF) of ischemic origin.Material and methods. The study included 127 patients with CHF, post myocardial infarction (age median 57 y. o., left ventricle ejection fraction — 54%), consequently admitted at Clinic. The biomarker concentrations representing myocardial stress (NT-proBNP) and fibrosis with remodeling of the ventricles (ST2) were measured with the immune enzyme assay. Endpoint was all-cause mortality and repeat hospitalizations during 9-month follow-up.Results. Levels of ST2 and NT-proBNP were higher in adverse outcome patients (n=19) comparing to the patients with no repeat cardiovascular events (р=0,004 and 0,001, respectively). Receiver operating characteristic (ROC) analysis for outcomes prediction defined the optimal threshold values of 43,6 ng/mL for ST2 and 285 pg/mL for NT-proBNP. In comparison of ROC-curves, biomarkers had comparable areas under the curves (p=0,659). In binary regression model, statistically significant predictors for combination endpoint were ST2, NT-proBNP and traditional risk factors (class by New York Heart Association, left ventricle aneurysm, stroke anamnesis, estimated glomerular filtration rate <90 mL/min/1,73 m2). The model had the under-curve-area 0,900 (p<0,001).Conclusion. ST2 and NT-proBNP are significant predictors of adverse clinical outcomes in CHF patients post myocardial infarction. |
| first_indexed | 2024-04-09T20:47:31Z |
| format | Article |
| id | doaj.art-2818f32de79a43849a793803c2fbc07b |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:47:31Z |
| publishDate | 2018-03-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-2818f32de79a43849a793803c2fbc07b2023-03-29T21:23:29Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202018-03-0101323610.15829/1560-4071-2018-1-32-362275BIOMARKERS OF MYOCARDIAL STRESS AND FIBROSIS FOR CLINICAL OUTCOMES ASSESSMENT IN POST MYOCARDIAL INFARCTION HEART FAILURE PATIENTSN V Shilyaeva0Y V Shchukin1L V Limareva2O P Danilchenko3Samara State Medical UniversitySamara State Medical UniversitySamara State Medical UniversitySamara State Medical UniversityAim. To assess the prognostic significance of the ST2 and N-terminal pre-brain natriuretic peptide (NT-proBNP) in patients with chronic heart failure (CHF) of ischemic origin.Material and methods. The study included 127 patients with CHF, post myocardial infarction (age median 57 y. o., left ventricle ejection fraction — 54%), consequently admitted at Clinic. The biomarker concentrations representing myocardial stress (NT-proBNP) and fibrosis with remodeling of the ventricles (ST2) were measured with the immune enzyme assay. Endpoint was all-cause mortality and repeat hospitalizations during 9-month follow-up.Results. Levels of ST2 and NT-proBNP were higher in adverse outcome patients (n=19) comparing to the patients with no repeat cardiovascular events (р=0,004 and 0,001, respectively). Receiver operating characteristic (ROC) analysis for outcomes prediction defined the optimal threshold values of 43,6 ng/mL for ST2 and 285 pg/mL for NT-proBNP. In comparison of ROC-curves, biomarkers had comparable areas under the curves (p=0,659). In binary regression model, statistically significant predictors for combination endpoint were ST2, NT-proBNP and traditional risk factors (class by New York Heart Association, left ventricle aneurysm, stroke anamnesis, estimated glomerular filtration rate <90 mL/min/1,73 m2). The model had the under-curve-area 0,900 (p<0,001).Conclusion. ST2 and NT-proBNP are significant predictors of adverse clinical outcomes in CHF patients post myocardial infarction.https://russjcardiol.elpub.ru/jour/article/view/2520heart failurebiomarkersst2nt-probnp |
| spellingShingle | N V Shilyaeva Y V Shchukin L V Limareva O P Danilchenko BIOMARKERS OF MYOCARDIAL STRESS AND FIBROSIS FOR CLINICAL OUTCOMES ASSESSMENT IN POST MYOCARDIAL INFARCTION HEART FAILURE PATIENTS Российский кардиологический журнал heart failure biomarkers st2 nt-probnp |
| title | BIOMARKERS OF MYOCARDIAL STRESS AND FIBROSIS FOR CLINICAL OUTCOMES ASSESSMENT IN POST MYOCARDIAL INFARCTION HEART FAILURE PATIENTS |
| title_full | BIOMARKERS OF MYOCARDIAL STRESS AND FIBROSIS FOR CLINICAL OUTCOMES ASSESSMENT IN POST MYOCARDIAL INFARCTION HEART FAILURE PATIENTS |
| title_fullStr | BIOMARKERS OF MYOCARDIAL STRESS AND FIBROSIS FOR CLINICAL OUTCOMES ASSESSMENT IN POST MYOCARDIAL INFARCTION HEART FAILURE PATIENTS |
| title_full_unstemmed | BIOMARKERS OF MYOCARDIAL STRESS AND FIBROSIS FOR CLINICAL OUTCOMES ASSESSMENT IN POST MYOCARDIAL INFARCTION HEART FAILURE PATIENTS |
| title_short | BIOMARKERS OF MYOCARDIAL STRESS AND FIBROSIS FOR CLINICAL OUTCOMES ASSESSMENT IN POST MYOCARDIAL INFARCTION HEART FAILURE PATIENTS |
| title_sort | biomarkers of myocardial stress and fibrosis for clinical outcomes assessment in post myocardial infarction heart failure patients |
| topic | heart failure biomarkers st2 nt-probnp |
| url | https://russjcardiol.elpub.ru/jour/article/view/2520 |
| work_keys_str_mv | AT nvshilyaeva biomarkersofmyocardialstressandfibrosisforclinicaloutcomesassessmentinpostmyocardialinfarctionheartfailurepatients AT yvshchukin biomarkersofmyocardialstressandfibrosisforclinicaloutcomesassessmentinpostmyocardialinfarctionheartfailurepatients AT lvlimareva biomarkersofmyocardialstressandfibrosisforclinicaloutcomesassessmentinpostmyocardialinfarctionheartfailurepatients AT opdanilchenko biomarkersofmyocardialstressandfibrosisforclinicaloutcomesassessmentinpostmyocardialinfarctionheartfailurepatients |