Developmental programming of obesity by maternal exposure to concentrated ambient PM2.5 is maternally transmitted into the third generation in a mouse model
Abstract Background Obesity is an uncontrolled global epidemic and one of the leading global public health challenges. Maternal exposure to ambient fine particulate matter (PM2.5) may adversely program offspring’s adiposity, suggesting a specialized role of PM2.5 pollution in the global obesity epid...
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| Format: | Article |
| Language: | English |
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BMC
2019-07-01
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| Series: | Particle and Fibre Toxicology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12989-019-0312-6 |
| _version_ | 1818035583106154496 |
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| author | Yanyi Xu Wanjun Wang Minjie Chen Ji Zhou Xingke Huang Shimin Tao Bin Pan Zhouzhou Li Xiaoyun Xie Weihua Li Haidong Kan Zhekang Ying |
| author_facet | Yanyi Xu Wanjun Wang Minjie Chen Ji Zhou Xingke Huang Shimin Tao Bin Pan Zhouzhou Li Xiaoyun Xie Weihua Li Haidong Kan Zhekang Ying |
| author_sort | Yanyi Xu |
| collection | DOAJ |
| description | Abstract Background Obesity is an uncontrolled global epidemic and one of the leading global public health challenges. Maternal exposure to ambient fine particulate matter (PM2.5) may adversely program offspring’s adiposity, suggesting a specialized role of PM2.5 pollution in the global obesity epidemic. However, the vulnerable window for this adverse programming and how it is cross-generationally transmitted have not been determined. Therefore, in the present study, female C57Bl/6 J mice were exposed to filtered air (FA) or concentrated ambient PM2.5 (CAP) during different periods, and the development and adulthood adiposity of their four-generational offspring were assessed. Results Our data show that the pre-conceptional but not gestational exposure to CAP was sufficient to cause male but not female offspring’s low birth weight, accelerated postnatal weight gain, and increased adulthood adiposity. These adverse developmental traits were transmitted into the F2 offspring born by the female but not male F1 offspring of CAP-exposed dams. In contrast, no adverse development was noted in the F3 offspring. Conclusions The present study identified a pre-conceptional window for the adverse programming of adiposity by maternal exposure to PM2.5, and showed that it was maternally transmitted into the third generation. These data not only call special attention to the protection of women from exposure to PM2.5, but also may facilitate the development of intervention to prevent this adverse programming. |
| first_indexed | 2024-12-10T06:57:21Z |
| format | Article |
| id | doaj.art-281bbc29e7544f809dc89535e94caf05 |
| institution | Directory Open Access Journal |
| issn | 1743-8977 |
| language | English |
| last_indexed | 2024-12-10T06:57:21Z |
| publishDate | 2019-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Particle and Fibre Toxicology |
| spelling | doaj.art-281bbc29e7544f809dc89535e94caf052022-12-22T01:58:25ZengBMCParticle and Fibre Toxicology1743-89772019-07-0116111110.1186/s12989-019-0312-6Developmental programming of obesity by maternal exposure to concentrated ambient PM2.5 is maternally transmitted into the third generation in a mouse modelYanyi Xu0Wanjun Wang1Minjie Chen2Ji Zhou3Xingke Huang4Shimin Tao5Bin Pan6Zhouzhou Li7Xiaoyun Xie8Weihua Li9Haidong Kan10Zhekang Ying11Department of Environmental Health, School of Public Health, Fudan UniversityDepartment of Environmental Health, School of Public Health, Fudan UniversityDepartment of Medicine Cardiology Division, University of Maryland School of MedicineShanghai Key Laboratory of Meteorology and Health, Shanghai Meteorological ServiceDepartment of Environmental Health, School of Public Health, Fudan UniversityNHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan UniversityDepartment of Environmental Health, School of Public Health, Fudan UniversityDepartment of Environmental Health, School of Public Health, Fudan UniversityDepartment of Interventional & Vascular Surgery, Shanghai Tenth People’s Hospital, Tongji University School of MedicineNHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan UniversityDepartment of Environmental Health, School of Public Health, Fudan UniversityDepartment of Medicine Cardiology Division, University of Maryland School of MedicineAbstract Background Obesity is an uncontrolled global epidemic and one of the leading global public health challenges. Maternal exposure to ambient fine particulate matter (PM2.5) may adversely program offspring’s adiposity, suggesting a specialized role of PM2.5 pollution in the global obesity epidemic. However, the vulnerable window for this adverse programming and how it is cross-generationally transmitted have not been determined. Therefore, in the present study, female C57Bl/6 J mice were exposed to filtered air (FA) or concentrated ambient PM2.5 (CAP) during different periods, and the development and adulthood adiposity of their four-generational offspring were assessed. Results Our data show that the pre-conceptional but not gestational exposure to CAP was sufficient to cause male but not female offspring’s low birth weight, accelerated postnatal weight gain, and increased adulthood adiposity. These adverse developmental traits were transmitted into the F2 offspring born by the female but not male F1 offspring of CAP-exposed dams. In contrast, no adverse development was noted in the F3 offspring. Conclusions The present study identified a pre-conceptional window for the adverse programming of adiposity by maternal exposure to PM2.5, and showed that it was maternally transmitted into the third generation. These data not only call special attention to the protection of women from exposure to PM2.5, but also may facilitate the development of intervention to prevent this adverse programming.http://link.springer.com/article/10.1186/s12989-019-0312-6PM2.5Maternal exposureObesityDevelopmental programmingCross-generational transmission |
| spellingShingle | Yanyi Xu Wanjun Wang Minjie Chen Ji Zhou Xingke Huang Shimin Tao Bin Pan Zhouzhou Li Xiaoyun Xie Weihua Li Haidong Kan Zhekang Ying Developmental programming of obesity by maternal exposure to concentrated ambient PM2.5 is maternally transmitted into the third generation in a mouse model Particle and Fibre Toxicology PM2.5 Maternal exposure Obesity Developmental programming Cross-generational transmission |
| title | Developmental programming of obesity by maternal exposure to concentrated ambient PM2.5 is maternally transmitted into the third generation in a mouse model |
| title_full | Developmental programming of obesity by maternal exposure to concentrated ambient PM2.5 is maternally transmitted into the third generation in a mouse model |
| title_fullStr | Developmental programming of obesity by maternal exposure to concentrated ambient PM2.5 is maternally transmitted into the third generation in a mouse model |
| title_full_unstemmed | Developmental programming of obesity by maternal exposure to concentrated ambient PM2.5 is maternally transmitted into the third generation in a mouse model |
| title_short | Developmental programming of obesity by maternal exposure to concentrated ambient PM2.5 is maternally transmitted into the third generation in a mouse model |
| title_sort | developmental programming of obesity by maternal exposure to concentrated ambient pm2 5 is maternally transmitted into the third generation in a mouse model |
| topic | PM2.5 Maternal exposure Obesity Developmental programming Cross-generational transmission |
| url | http://link.springer.com/article/10.1186/s12989-019-0312-6 |
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