Physical Cues of Matrices Reeducate Nerve Cells
The behavior of nerve cells plays a crucial role in nerve regeneration. The mechanical, topographical, and electrical microenvironment surrounding nerve cells can activate cellular signaling pathways of mechanical transduction to affect the behavior of nerve cells. Recently, biological scaffolds wit...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.731170/full |
| _version_ | 1818887921438031872 |
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| author | Yiqian Luo Jie Li Baoqin Li Yuanliang Xia Hengyi Wang Changfeng Fu |
| author_facet | Yiqian Luo Jie Li Baoqin Li Yuanliang Xia Hengyi Wang Changfeng Fu |
| author_sort | Yiqian Luo |
| collection | DOAJ |
| description | The behavior of nerve cells plays a crucial role in nerve regeneration. The mechanical, topographical, and electrical microenvironment surrounding nerve cells can activate cellular signaling pathways of mechanical transduction to affect the behavior of nerve cells. Recently, biological scaffolds with various physical properties have been developed as extracellular matrix to regulate the behavior conversion of nerve cell, such as neuronal neurite growth and directional differentiation of neural stem cells, providing a robust driving force for nerve regeneration. This review mainly focused on the biological basis of nerve cells in mechanical transduction. In addition, we also highlighted the effect of the physical cues, including stiffness, mechanical tension, two-dimensional terrain, and electrical conductivity, on neurite outgrowth and differentiation of neural stem cells and predicted their potential application in clinical nerve tissue engineering. |
| first_indexed | 2024-12-19T16:44:55Z |
| format | Article |
| id | doaj.art-281eba58b30444479f097cf300392118 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-19T16:44:55Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-281eba58b30444479f097cf3003921182022-12-21T20:13:40ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-09-01910.3389/fcell.2021.731170731170Physical Cues of Matrices Reeducate Nerve CellsYiqian LuoJie LiBaoqin LiYuanliang XiaHengyi WangChangfeng FuThe behavior of nerve cells plays a crucial role in nerve regeneration. The mechanical, topographical, and electrical microenvironment surrounding nerve cells can activate cellular signaling pathways of mechanical transduction to affect the behavior of nerve cells. Recently, biological scaffolds with various physical properties have been developed as extracellular matrix to regulate the behavior conversion of nerve cell, such as neuronal neurite growth and directional differentiation of neural stem cells, providing a robust driving force for nerve regeneration. This review mainly focused on the biological basis of nerve cells in mechanical transduction. In addition, we also highlighted the effect of the physical cues, including stiffness, mechanical tension, two-dimensional terrain, and electrical conductivity, on neurite outgrowth and differentiation of neural stem cells and predicted their potential application in clinical nerve tissue engineering.https://www.frontiersin.org/articles/10.3389/fcell.2021.731170/fullphysical cuemechanical transductionneuriteneural stem cellnerve regeneration |
| spellingShingle | Yiqian Luo Jie Li Baoqin Li Yuanliang Xia Hengyi Wang Changfeng Fu Physical Cues of Matrices Reeducate Nerve Cells Frontiers in Cell and Developmental Biology physical cue mechanical transduction neurite neural stem cell nerve regeneration |
| title | Physical Cues of Matrices Reeducate Nerve Cells |
| title_full | Physical Cues of Matrices Reeducate Nerve Cells |
| title_fullStr | Physical Cues of Matrices Reeducate Nerve Cells |
| title_full_unstemmed | Physical Cues of Matrices Reeducate Nerve Cells |
| title_short | Physical Cues of Matrices Reeducate Nerve Cells |
| title_sort | physical cues of matrices reeducate nerve cells |
| topic | physical cue mechanical transduction neurite neural stem cell nerve regeneration |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.731170/full |
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