Use of zebrafish to study Shigella infection
Shigella is a leading cause of dysentery worldwide, responsible for up to 165 million cases of shigellosis each year. Shigella is also recognised as an exceptional model pathogen to study key issues in cell biology and innate immunity. Several infection models have been useful to explore Shigella bi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
The Company of Biologists
2018-02-01
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| Series: | Disease Models & Mechanisms |
| Subjects: | |
| Online Access: | http://dmm.biologists.org/content/11/2/dmm032151 |
| _version_ | 1811292157589323776 |
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| author | Gina M. Duggan Serge Mostowy |
| author_facet | Gina M. Duggan Serge Mostowy |
| author_sort | Gina M. Duggan |
| collection | DOAJ |
| description | Shigella is a leading cause of dysentery worldwide, responsible for up to 165 million cases of shigellosis each year. Shigella is also recognised as an exceptional model pathogen to study key issues in cell biology and innate immunity. Several infection models have been useful to explore Shigella biology; however, we still lack information regarding the events taking place during the Shigella infection process in vivo. Here, we discuss a selection of mechanistic insights recently gained from studying Shigella infection of zebrafish (Danio rerio), with a focus on cytoskeleton rearrangements and cellular immunity. We also discuss how infection of zebrafish can be used to investigate new concepts underlying infection control, including emergency granulopoiesis and the use of predatory bacteria to combat antimicrobial resistance. Collectively, these insights illustrate how Shigella infection of zebrafish can provide fundamental advances in our understanding of bacterial pathogenesis and vertebrate host defence. This information should also provide vital clues for the discovery of new therapeutic strategies against infectious disease in humans. |
| first_indexed | 2024-04-13T04:41:14Z |
| format | Article |
| id | doaj.art-281ebe5e91c44731a599cf42926da2c3 |
| institution | Directory Open Access Journal |
| issn | 1754-8403 1754-8411 |
| language | English |
| last_indexed | 2024-04-13T04:41:14Z |
| publishDate | 2018-02-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Disease Models & Mechanisms |
| spelling | doaj.art-281ebe5e91c44731a599cf42926da2c32022-12-22T03:01:59ZengThe Company of BiologistsDisease Models & Mechanisms1754-84031754-84112018-02-0111210.1242/dmm.032151032151Use of zebrafish to study Shigella infectionGina M. Duggan0Serge Mostowy1 Section of Microbiology, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, UK Section of Microbiology, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, UK Shigella is a leading cause of dysentery worldwide, responsible for up to 165 million cases of shigellosis each year. Shigella is also recognised as an exceptional model pathogen to study key issues in cell biology and innate immunity. Several infection models have been useful to explore Shigella biology; however, we still lack information regarding the events taking place during the Shigella infection process in vivo. Here, we discuss a selection of mechanistic insights recently gained from studying Shigella infection of zebrafish (Danio rerio), with a focus on cytoskeleton rearrangements and cellular immunity. We also discuss how infection of zebrafish can be used to investigate new concepts underlying infection control, including emergency granulopoiesis and the use of predatory bacteria to combat antimicrobial resistance. Collectively, these insights illustrate how Shigella infection of zebrafish can provide fundamental advances in our understanding of bacterial pathogenesis and vertebrate host defence. This information should also provide vital clues for the discovery of new therapeutic strategies against infectious disease in humans.http://dmm.biologists.org/content/11/2/dmm032151Antimicrobial resistanceAutophagyCytoskeletonEmergency granulopoiesisInflammationMacrophageNeutrophilSeptinShigellaZebrafish |
| spellingShingle | Gina M. Duggan Serge Mostowy Use of zebrafish to study Shigella infection Disease Models & Mechanisms Antimicrobial resistance Autophagy Cytoskeleton Emergency granulopoiesis Inflammation Macrophage Neutrophil Septin Shigella Zebrafish |
| title | Use of zebrafish to study Shigella infection |
| title_full | Use of zebrafish to study Shigella infection |
| title_fullStr | Use of zebrafish to study Shigella infection |
| title_full_unstemmed | Use of zebrafish to study Shigella infection |
| title_short | Use of zebrafish to study Shigella infection |
| title_sort | use of zebrafish to study shigella infection |
| topic | Antimicrobial resistance Autophagy Cytoskeleton Emergency granulopoiesis Inflammation Macrophage Neutrophil Septin Shigella Zebrafish |
| url | http://dmm.biologists.org/content/11/2/dmm032151 |
| work_keys_str_mv | AT ginamduggan useofzebrafishtostudyshigellainfection AT sergemostowy useofzebrafishtostudyshigellainfection |