The Signal Peptide and Chaperone UNC93B1 Both Influence TLR8 Ectodomain Intracellular Endosomal Localization

The Signal Peptide and Chaperone UNC93B1 Both Influence TLR8 Ectodomain Intracellular Endosomal Localization

Toll-like receptor 8 (TLR8) is a single-stranded RNA sensing receptor and is localized in the cellular compartments, where it encounters foreign or self-nucleic acids and activates innate and adaptive immune responses. However, the mechanism controlling intracellular localization TLR8 is not complet...

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Bibliographic Details
Main Authors: Da Ao, Xueliang Liu, Sen Jiang, Yulin Xu, Wanglong Zheng, Nanhua Chen, François Meurens, Jianzhong Zhu
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Vaccines
Subjects:
TLR8
ectodomain
intracellular localization
posttranslational modification
signal peptide
UNC93B1
Online Access:https://www.mdpi.com/2076-393X/10/1/14

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