Bacterial ribosomal RNA detection in cerebrospinal fluid using a viromics approach

Bacterial ribosomal RNA detection in cerebrospinal fluid using a viromics approach

Key points We demonstrate that an unmodified viromic next-generation sequencing methodology effectively detects bacterial pathogen ribosomal RNA in cerebrospinal fluid samples. Sensitivity and specificity displayed pathogen dependent variation. Our finding in principle offers avenues for simultaneou...

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Bibliographic Details
Main Authors: Cormac M. Kinsella, Arthur W. D. Edridge, Ingeborg E. van Zeggeren, Martin Deijs, Diederik van de Beek, Matthijs C. Brouwer, Lia van der Hoek
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Fluids and Barriers of the CNS
Subjects:
Bacterial meningitis
Pathogen detection
Cerebrospinal fluid
Viromics
Metagenomics
Online Access:https://doi.org/10.1186/s12987-022-00400-5

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