Reversible GABAergic dysfunction involved in hippocampal hyperactivity predicts early-stage Alzheimer disease in a mouse model

Reversible GABAergic dysfunction involved in hippocampal hyperactivity predicts early-stage Alzheimer disease in a mouse model

Abstract Background Neuronal hyperactivity related to β-amyloid (Aβ) is considered an early warning sign of Alzheimer disease (AD). Although increasing evidence supports this opinion, the underlying mechanisms are still unknown. Methods Here, we recorded whole-cell synaptic currents and membrane pot...

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Bibliographic Details
Main Authors: Yang Li, Ke Zhu, Ning Li, Xiaotong Wang, Xuansheng Xiao, Linying Li, Lijuan Li, Ying He, Jinglan Zhang, Jiaoyang Wo, Yanqiu Cui, Haixia Huang, Jianliang Zhang, Wei Wang, Xiaomin Wang, Yan Zheng
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Alzheimer’s Research & Therapy
Subjects:
Neuronal hyperactivity
Synaptic transmission
Alzheimer’s disease
GABAA receptors
5XFAD mouse
Online Access:https://doi.org/10.1186/s13195-021-00859-8

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