Maternal exposure to urinary polycyclic aromatic hydrocarbons (PAH) in pregnancy and childhood asthma in a pooled multi-cohort study
Background: Prenatal exposure to polycyclic aromatic hydrocarbons (PAH) may increase risk of pediatric asthma, but existing human studies are limited. Objectives: We estimated associations between gestational PAHs and pediatric asthma in a diverse US sample and evaluated effect modification by child...
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| Language: | English |
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Elsevier
2022-12-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412022004214 |
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| author | Christine T. Loftus Adam A. Szpiro Tomomi Workman Erin R. Wallace Marnie F. Hazlehurst Drew B. Day Yu Ni Kecia N. Carroll Margaret A. Adgent Paul E. Moore Emily S Barrett Ruby H.N. Nguyen Kurunthachalam Kannan Morgan Robinson Erin E. Masterson Frances A. Tylavsky Nicole R. Bush Kaja Z. LeWinn Sheela Sathyanarayana Catherine J. Karr |
| author_facet | Christine T. Loftus Adam A. Szpiro Tomomi Workman Erin R. Wallace Marnie F. Hazlehurst Drew B. Day Yu Ni Kecia N. Carroll Margaret A. Adgent Paul E. Moore Emily S Barrett Ruby H.N. Nguyen Kurunthachalam Kannan Morgan Robinson Erin E. Masterson Frances A. Tylavsky Nicole R. Bush Kaja Z. LeWinn Sheela Sathyanarayana Catherine J. Karr |
| author_sort | Christine T. Loftus |
| collection | DOAJ |
| description | Background: Prenatal exposure to polycyclic aromatic hydrocarbons (PAH) may increase risk of pediatric asthma, but existing human studies are limited. Objectives: We estimated associations between gestational PAHs and pediatric asthma in a diverse US sample and evaluated effect modification by child sex, maternal asthma, and prenatal vitamin D status. Methods: We pooled two prospective pregnancy cohorts in the ECHO PATHWAYS Consortium, CANDLE and TIDES, for an analytic sample of N = 1296 mother–child dyads. Mono-hydroxylated PAH metabolites (OH-PAHs) were measured in mid-pregnancy urine. Mothers completed the International Study on Allergies and Asthma in Childhood survey at child age 4–6 years. Poisson regression with robust standard errors was used to estimate relative risk of current wheeze, current asthma, ever asthma, and strict asthma associated with each metabolite, adjusted for potential confounders. We used interaction models to assess effect modification. We explored associations between OH-PAH mixtures and outcomes using logistic weighted quantile sum regression augmented by a permutation test to control Type 1 errors. Results: The sociodemographically diverse sample spanned five cities. Mean (SD) child age at assessment was 4.4 (0.4) years. While there was little evidence that either individual OH-PAHs or mixtures were associated with outcomes, we observed effect modification by child sex for most pairs of OH-PAHs and outcomes, with adverse associations specific to females. For example, a 2-fold increase in 2-hydroxy-phenanthrene was associated with current asthma in females but not males (RRfemale = 1.29 [95 % CI: 1.09, 1.52], RRmale = 0.95 [95 % CI: 0.79, 1.13]; pinteraction = 0.004). There was no consistent evidence of modification by vitamin D status or maternal asthma. Discussion: This analysis, the largest cohort study of gestational PAH exposure and childhood asthma to date, suggests adverse associations for females only. These preliminary findings are consistent with hypothesized endocrine disruption properties of PAHs, which may lead to sexually dimorphic effects. |
| first_indexed | 2024-04-13T11:39:20Z |
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| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-04-13T11:39:20Z |
| publishDate | 2022-12-01 |
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| spelling | doaj.art-2828f433b0fe43dea9f27b2c30f0323b2022-12-22T02:48:20ZengElsevierEnvironment International0160-41202022-12-01170107494Maternal exposure to urinary polycyclic aromatic hydrocarbons (PAH) in pregnancy and childhood asthma in a pooled multi-cohort studyChristine T. Loftus0Adam A. Szpiro1Tomomi Workman2Erin R. Wallace3Marnie F. Hazlehurst4Drew B. Day5Yu Ni6Kecia N. Carroll7Margaret A. Adgent8Paul E. Moore9Emily S Barrett10Ruby H.N. Nguyen11Kurunthachalam Kannan12Morgan Robinson13Erin E. Masterson14Frances A. Tylavsky15Nicole R. Bush16Kaja Z. LeWinn17Sheela Sathyanarayana18Catherine J. Karr19Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA; Corresponding author at: 4225 Roosevelt Way NE, Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, Seattle, WA 98105, USA.Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USADepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USADepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USADepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USADepartment of Child Health, Behavior, and Development, Seattle Children’s Research Institute, Seattle, WA, USADepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USADepartment of Pediatrics, Department of Environmental Medicine & Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USADepartment of Pediatrics, College of Medicine, Vanderbilt University Medical Center, Nashville, TN, USADivision of Allergy, Immunology, and Pulmonology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USADepartment of Epidemiology, Environmental and Occupational Health Sciences Institute, Rutgers School of Public Health, Piscataway, NJ, USADivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USADepartment of Pediatrics, Department of Environmental Medicine, New York University School of Medicine, New York City, NY, USADepartment of Pediatrics, Department of Environmental Medicine, New York University School of Medicine, New York City, NY, USADepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USADepartment of Preventive Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USADepartment of Psychiatry and Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA, USADepartment of Psychiatry and Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA, USADepartment of Child Health, Behavior, and Development, Seattle Children’s Research Institute, Seattle, WA, USA; Department of Pediatrics, School of Medicine, Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USADepartment of Pediatrics, School of Medicine, Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USABackground: Prenatal exposure to polycyclic aromatic hydrocarbons (PAH) may increase risk of pediatric asthma, but existing human studies are limited. Objectives: We estimated associations between gestational PAHs and pediatric asthma in a diverse US sample and evaluated effect modification by child sex, maternal asthma, and prenatal vitamin D status. Methods: We pooled two prospective pregnancy cohorts in the ECHO PATHWAYS Consortium, CANDLE and TIDES, for an analytic sample of N = 1296 mother–child dyads. Mono-hydroxylated PAH metabolites (OH-PAHs) were measured in mid-pregnancy urine. Mothers completed the International Study on Allergies and Asthma in Childhood survey at child age 4–6 years. Poisson regression with robust standard errors was used to estimate relative risk of current wheeze, current asthma, ever asthma, and strict asthma associated with each metabolite, adjusted for potential confounders. We used interaction models to assess effect modification. We explored associations between OH-PAH mixtures and outcomes using logistic weighted quantile sum regression augmented by a permutation test to control Type 1 errors. Results: The sociodemographically diverse sample spanned five cities. Mean (SD) child age at assessment was 4.4 (0.4) years. While there was little evidence that either individual OH-PAHs or mixtures were associated with outcomes, we observed effect modification by child sex for most pairs of OH-PAHs and outcomes, with adverse associations specific to females. For example, a 2-fold increase in 2-hydroxy-phenanthrene was associated with current asthma in females but not males (RRfemale = 1.29 [95 % CI: 1.09, 1.52], RRmale = 0.95 [95 % CI: 0.79, 1.13]; pinteraction = 0.004). There was no consistent evidence of modification by vitamin D status or maternal asthma. Discussion: This analysis, the largest cohort study of gestational PAH exposure and childhood asthma to date, suggests adverse associations for females only. These preliminary findings are consistent with hypothesized endocrine disruption properties of PAHs, which may lead to sexually dimorphic effects.http://www.sciencedirect.com/science/article/pii/S0160412022004214Pediatric asthmaAirwayEndocrine disruptionPolycyclic aromatic hydrocarbonsMixtures |
| spellingShingle | Christine T. Loftus Adam A. Szpiro Tomomi Workman Erin R. Wallace Marnie F. Hazlehurst Drew B. Day Yu Ni Kecia N. Carroll Margaret A. Adgent Paul E. Moore Emily S Barrett Ruby H.N. Nguyen Kurunthachalam Kannan Morgan Robinson Erin E. Masterson Frances A. Tylavsky Nicole R. Bush Kaja Z. LeWinn Sheela Sathyanarayana Catherine J. Karr Maternal exposure to urinary polycyclic aromatic hydrocarbons (PAH) in pregnancy and childhood asthma in a pooled multi-cohort study Environment International Pediatric asthma Airway Endocrine disruption Polycyclic aromatic hydrocarbons Mixtures |
| title | Maternal exposure to urinary polycyclic aromatic hydrocarbons (PAH) in pregnancy and childhood asthma in a pooled multi-cohort study |
| title_full | Maternal exposure to urinary polycyclic aromatic hydrocarbons (PAH) in pregnancy and childhood asthma in a pooled multi-cohort study |
| title_fullStr | Maternal exposure to urinary polycyclic aromatic hydrocarbons (PAH) in pregnancy and childhood asthma in a pooled multi-cohort study |
| title_full_unstemmed | Maternal exposure to urinary polycyclic aromatic hydrocarbons (PAH) in pregnancy and childhood asthma in a pooled multi-cohort study |
| title_short | Maternal exposure to urinary polycyclic aromatic hydrocarbons (PAH) in pregnancy and childhood asthma in a pooled multi-cohort study |
| title_sort | maternal exposure to urinary polycyclic aromatic hydrocarbons pah in pregnancy and childhood asthma in a pooled multi cohort study |
| topic | Pediatric asthma Airway Endocrine disruption Polycyclic aromatic hydrocarbons Mixtures |
| url | http://www.sciencedirect.com/science/article/pii/S0160412022004214 |
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