Clinical Features and Prognostic Factors of Acute Ischemic Stroke Related to Malignant Gastrointestinal Tumor
Objectives: To analyze the clinical and imaging features of acute ischemic stroke (AIS) related to gastrointestinal malignant tumor, and to explore the prognostic factors.Methods: Clinical data of consecutive patients with gastrointestinal malignant tumor complicated with AIS admitted to the Departm...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-11-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.777483/full |
| _version_ | 1818346477530906624 |
|---|---|
| author | Yating Liu Yating Liu Xin Li Feixue Song Xin Yan Zhijian Han Futian Tang Yumin Li |
| author_facet | Yating Liu Yating Liu Xin Li Feixue Song Xin Yan Zhijian Han Futian Tang Yumin Li |
| author_sort | Yating Liu |
| collection | DOAJ |
| description | Objectives: To analyze the clinical and imaging features of acute ischemic stroke (AIS) related to gastrointestinal malignant tumor, and to explore the prognostic factors.Methods: Clinical data of consecutive patients with gastrointestinal malignant tumor complicated with AIS admitted to the Department of Neurology and Oncology in Lanzhou University Second Hospital from April 2015 to April 2019 were retrospectively analyzed. Patients were divided into good prognosis (mRS 0–2) and poor prognosis (mRS > 2) based on a 90-day mRS score after discharge. The multivariate logistic regression model was used to analyze the prognostic factors.Results: A total of 68 patients were enrolled with an average age of 61.78 ± 6.65 years, including 49 men (72.06%). There were 18 patients in the good prognosis group and 50 patients in the poor prognosis group. The univariate analysis showed that Hcy, D-dimer, thrombin–antithrombin complex (TAT), and three territory sign in magnetic resonance imaging (MRI) were the risk factors for poor prognosis. Multivariate analysis showed that increased D-dimer (OR 4.497, 95% CI 1.014–19.938) and TAT levels (OR 4.294, 95% CI 1.654–11.149) were independent risk factors for the prognosis in such patients.Conclusion: Image of patients with gastrointestinal malignant tumor-related AIS is characterized by three territory sign (multiple lesions in different vascular supply areas). Increased TAT and D-dimer levels are independent prognostic risk factors. TAT is more sensitive to predict prognosis than D-dimer. |
| first_indexed | 2024-12-13T17:18:53Z |
| format | Article |
| id | doaj.art-28292850cd5a4fea86e04fd84e9fde8a |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-13T17:18:53Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-28292850cd5a4fea86e04fd84e9fde8a2022-12-21T23:37:22ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-11-011210.3389/fneur.2021.777483777483Clinical Features and Prognostic Factors of Acute Ischemic Stroke Related to Malignant Gastrointestinal TumorYating Liu0Yating Liu1Xin Li2Feixue Song3Xin Yan4Zhijian Han5Futian Tang6Yumin Li7Department of Oncology, Lanzhou University Second Hospital, Lanzhou, ChinaKey Laboratory of the Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou, ChinaDepartment of Neurology, Lanzhou University Second Hospital, Lanzhou, ChinaDepartment of Oncology, Lanzhou University Second Hospital, Lanzhou, ChinaKey Laboratory of the Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou, ChinaKey Laboratory of the Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou, ChinaKey Laboratory of the Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou, ChinaKey Laboratory of the Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou, ChinaObjectives: To analyze the clinical and imaging features of acute ischemic stroke (AIS) related to gastrointestinal malignant tumor, and to explore the prognostic factors.Methods: Clinical data of consecutive patients with gastrointestinal malignant tumor complicated with AIS admitted to the Department of Neurology and Oncology in Lanzhou University Second Hospital from April 2015 to April 2019 were retrospectively analyzed. Patients were divided into good prognosis (mRS 0–2) and poor prognosis (mRS > 2) based on a 90-day mRS score after discharge. The multivariate logistic regression model was used to analyze the prognostic factors.Results: A total of 68 patients were enrolled with an average age of 61.78 ± 6.65 years, including 49 men (72.06%). There were 18 patients in the good prognosis group and 50 patients in the poor prognosis group. The univariate analysis showed that Hcy, D-dimer, thrombin–antithrombin complex (TAT), and three territory sign in magnetic resonance imaging (MRI) were the risk factors for poor prognosis. Multivariate analysis showed that increased D-dimer (OR 4.497, 95% CI 1.014–19.938) and TAT levels (OR 4.294, 95% CI 1.654–11.149) were independent risk factors for the prognosis in such patients.Conclusion: Image of patients with gastrointestinal malignant tumor-related AIS is characterized by three territory sign (multiple lesions in different vascular supply areas). Increased TAT and D-dimer levels are independent prognostic risk factors. TAT is more sensitive to predict prognosis than D-dimer.https://www.frontiersin.org/articles/10.3389/fneur.2021.777483/fullgastrointestinal malignant tumoracute ischemic strokeD-dimer (DD)TATprognosis |
| spellingShingle | Yating Liu Yating Liu Xin Li Feixue Song Xin Yan Zhijian Han Futian Tang Yumin Li Clinical Features and Prognostic Factors of Acute Ischemic Stroke Related to Malignant Gastrointestinal Tumor Frontiers in Neurology gastrointestinal malignant tumor acute ischemic stroke D-dimer (DD) TAT prognosis |
| title | Clinical Features and Prognostic Factors of Acute Ischemic Stroke Related to Malignant Gastrointestinal Tumor |
| title_full | Clinical Features and Prognostic Factors of Acute Ischemic Stroke Related to Malignant Gastrointestinal Tumor |
| title_fullStr | Clinical Features and Prognostic Factors of Acute Ischemic Stroke Related to Malignant Gastrointestinal Tumor |
| title_full_unstemmed | Clinical Features and Prognostic Factors of Acute Ischemic Stroke Related to Malignant Gastrointestinal Tumor |
| title_short | Clinical Features and Prognostic Factors of Acute Ischemic Stroke Related to Malignant Gastrointestinal Tumor |
| title_sort | clinical features and prognostic factors of acute ischemic stroke related to malignant gastrointestinal tumor |
| topic | gastrointestinal malignant tumor acute ischemic stroke D-dimer (DD) TAT prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.777483/full |
| work_keys_str_mv | AT yatingliu clinicalfeaturesandprognosticfactorsofacuteischemicstrokerelatedtomalignantgastrointestinaltumor AT yatingliu clinicalfeaturesandprognosticfactorsofacuteischemicstrokerelatedtomalignantgastrointestinaltumor AT xinli clinicalfeaturesandprognosticfactorsofacuteischemicstrokerelatedtomalignantgastrointestinaltumor AT feixuesong clinicalfeaturesandprognosticfactorsofacuteischemicstrokerelatedtomalignantgastrointestinaltumor AT xinyan clinicalfeaturesandprognosticfactorsofacuteischemicstrokerelatedtomalignantgastrointestinaltumor AT zhijianhan clinicalfeaturesandprognosticfactorsofacuteischemicstrokerelatedtomalignantgastrointestinaltumor AT futiantang clinicalfeaturesandprognosticfactorsofacuteischemicstrokerelatedtomalignantgastrointestinaltumor AT yuminli clinicalfeaturesandprognosticfactorsofacuteischemicstrokerelatedtomalignantgastrointestinaltumor |