Research progress of tumor-associated macrophages in immune microenvironment and targeted therapy of osteosarcoma
Osteosarcoma (OS) is a common primary malignant bone tumor in children and adolescents. The high recurrence and metastasis rate have become a common clinical problem to be solved, but there is no effective treatment. In recent years, studies have suggested that targeting the tumor microenvironment w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science)
2023-05-01
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| Series: | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| Subjects: | |
| Online Access: | https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-5-624.shtml |
| _version_ | 1827241484812812288 |
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| author | WEI Lanyi XUE Xiaochuan CHEN Junjun YANG Quanjun WANG Mengyue HAN Yonglong |
| author_facet | WEI Lanyi XUE Xiaochuan CHEN Junjun YANG Quanjun WANG Mengyue HAN Yonglong |
| author_sort | WEI Lanyi |
| collection | DOAJ |
| description | Osteosarcoma (OS) is a common primary malignant bone tumor in children and adolescents. The high recurrence and metastasis rate have become a common clinical problem to be solved, but there is no effective treatment. In recent years, studies have suggested that targeting the tumor microenvironment will likely become a new treatment direction for OS. Immune cell infiltration in the tumor microenvironment can promote tumor inflammation and angiogenesis. Tumor-associated macrophages (TAMs) are the most important immune cells in the tumor microenvironment, which play important roles in the development and metastasis of OS. The article reviews the effect of TAMs polarization on tumor cells and describes the effect of TAMs on the occurrence and development of OS from five aspects, including TAMs affecting the growth, invasion and metastasis, mediating chemotherapy resistance, stem cell-like phenotype, and immunosuppression of OS. The review summarizes the research progress of targeting TAMs in the treatment of OS in the past years, including influencing the recruitment of TAMs, promoting the polarization of M2 type to M1 type, targeting CD47 to promote the phagocytosis of TAMs, and targeting the immune checkpoint of TAMs, aiming to provide new directions and ideas for targeted therapy of OS. |
| first_indexed | 2024-03-08T21:51:46Z |
| format | Article |
| id | doaj.art-2829835352ce46e9b008ea7993e6ae32 |
| institution | Directory Open Access Journal |
| issn | 1674-8115 |
| language | zho |
| last_indexed | 2025-03-21T21:41:13Z |
| publishDate | 2023-05-01 |
| publisher | Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) |
| record_format | Article |
| series | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| spelling | doaj.art-2829835352ce46e9b008ea7993e6ae322024-05-27T06:09:48ZzhoEditorial Office of Journal of Shanghai Jiao Tong University (Medical Science)Shanghai Jiaotong Daxue xuebao. Yixue ban1674-81152023-05-0143562463010.3969/j.issn.1674-8115.2023.05.0141674-8115（2023）05-0624-07Research progress of tumor-associated macrophages in immune microenvironment and targeted therapy of osteosarcomaWEI Lanyi0XUE Xiaochuan1CHEN Junjun2YANG Quanjun3WANG Mengyue4HAN Yonglong5Department of Pharmacy, Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaDepartment of Pharmacy, Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaDepartment of Pharmacy, Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaDepartment of Pharmacy, Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai 201109, ChinaDepartment of Pharmacy, Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaOsteosarcoma (OS) is a common primary malignant bone tumor in children and adolescents. The high recurrence and metastasis rate have become a common clinical problem to be solved, but there is no effective treatment. In recent years, studies have suggested that targeting the tumor microenvironment will likely become a new treatment direction for OS. Immune cell infiltration in the tumor microenvironment can promote tumor inflammation and angiogenesis. Tumor-associated macrophages (TAMs) are the most important immune cells in the tumor microenvironment, which play important roles in the development and metastasis of OS. The article reviews the effect of TAMs polarization on tumor cells and describes the effect of TAMs on the occurrence and development of OS from five aspects, including TAMs affecting the growth, invasion and metastasis, mediating chemotherapy resistance, stem cell-like phenotype, and immunosuppression of OS. The review summarizes the research progress of targeting TAMs in the treatment of OS in the past years, including influencing the recruitment of TAMs, promoting the polarization of M2 type to M1 type, targeting CD47 to promote the phagocytosis of TAMs, and targeting the immune checkpoint of TAMs, aiming to provide new directions and ideas for targeted therapy of OS.https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-5-624.shtmlosteosarcomatumor-associated macrophagestumor microenvironmenttargeted therapy |
| spellingShingle | WEI Lanyi XUE Xiaochuan CHEN Junjun YANG Quanjun WANG Mengyue HAN Yonglong Research progress of tumor-associated macrophages in immune microenvironment and targeted therapy of osteosarcoma Shanghai Jiaotong Daxue xuebao. Yixue ban osteosarcoma tumor-associated macrophages tumor microenvironment targeted therapy |
| title | Research progress of tumor-associated macrophages in immune microenvironment and targeted therapy of osteosarcoma |
| title_full | Research progress of tumor-associated macrophages in immune microenvironment and targeted therapy of osteosarcoma |
| title_fullStr | Research progress of tumor-associated macrophages in immune microenvironment and targeted therapy of osteosarcoma |
| title_full_unstemmed | Research progress of tumor-associated macrophages in immune microenvironment and targeted therapy of osteosarcoma |
| title_short | Research progress of tumor-associated macrophages in immune microenvironment and targeted therapy of osteosarcoma |
| title_sort | research progress of tumor associated macrophages in immune microenvironment and targeted therapy of osteosarcoma |
| topic | osteosarcoma tumor-associated macrophages tumor microenvironment targeted therapy |
| url | https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-5-624.shtml |
| work_keys_str_mv | AT weilanyi researchprogressoftumorassociatedmacrophagesinimmunemicroenvironmentandtargetedtherapyofosteosarcoma AT xuexiaochuan researchprogressoftumorassociatedmacrophagesinimmunemicroenvironmentandtargetedtherapyofosteosarcoma AT chenjunjun researchprogressoftumorassociatedmacrophagesinimmunemicroenvironmentandtargetedtherapyofosteosarcoma AT yangquanjun researchprogressoftumorassociatedmacrophagesinimmunemicroenvironmentandtargetedtherapyofosteosarcoma AT wangmengyue researchprogressoftumorassociatedmacrophagesinimmunemicroenvironmentandtargetedtherapyofosteosarcoma AT hanyonglong researchprogressoftumorassociatedmacrophagesinimmunemicroenvironmentandtargetedtherapyofosteosarcoma |