Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival
<p>Abstract</p> <p>Background</p> <p>Altered androgen hormone homeostasis and androgen receptor (AR) activity have been implicated in ovarian carcinogenesis but the relationship between AR expression in ovarian cancer and clinical outcome remains unclear.</p> <...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-06-01
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| Series: | Journal of Ovarian Research |
| Online Access: | http://www.ovarianresearch.com/content/3/1/14 |
| _version_ | 1797969182545936384 |
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| author | Nodin Björn Zendehrokh Nooreldin Brändstedt Jenny Nilsson Elise Manjer Jonas Brennan Donal J Jirström Karin |
| author_facet | Nodin Björn Zendehrokh Nooreldin Brändstedt Jenny Nilsson Elise Manjer Jonas Brennan Donal J Jirström Karin |
| author_sort | Nodin Björn |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Altered androgen hormone homeostasis and androgen receptor (AR) activity have been implicated in ovarian carcinogenesis but the relationship between AR expression in ovarian cancer and clinical outcome remains unclear.</p> <p>Methods</p> <p>In this study, the prognostic impact of AR expression was investigated using immunohistochemistry in tissue microarrays from 154 incident cases of epithelial ovarian cancer (EOC) in the prospective, population-based cohorts Malmö Diet and Cancer Study and Malmö Preventive Project. A subset of corresponding fallopian tubes (n = 36) with no histopathological evidence of disease was also analysed.</p> <p>Results</p> <p>While abundantly expressed in the majority of fallopian tubes with more than 75% positive nuclei in 16/36 (44%) cases, AR was absent in 108/154 (70%) of EOC cases. AR expression was not related to prognosis in the entire cohort, but in the serous subtype (n = 90), AR positivity (> 10% positive nuclei) was associated with a prolonged disease specific survival in univariate (HR= 0.49; 95% CI 0.25-0.96; p= 0.038) and multivariate (HR= 0.46; 95% CI 0.22-0.97; p= 0.042) analysis, adjusted for age, grade and clinical stage.</p> <p>Conclusions</p> <p>AR expression is considerably reduced in EOC as compared to fallopian tubes, and in EOC of the serous subtype, high AR expression is a favourable prognostic factor. These results indicate that assessment of AR expression might be of value for treatment stratification of EOC patients with serous ovarian carcinoma.</p> |
| first_indexed | 2024-04-11T02:58:09Z |
| format | Article |
| id | doaj.art-2829cd98401f4bb8937e200581e18908 |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T02:58:09Z |
| publishDate | 2010-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-2829cd98401f4bb8937e200581e189082023-01-02T14:33:08ZengBMCJournal of Ovarian Research1757-22152010-06-01311410.1186/1757-2215-3-14Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survivalNodin BjörnZendehrokh NooreldinBrändstedt JennyNilsson EliseManjer JonasBrennan Donal JJirström Karin<p>Abstract</p> <p>Background</p> <p>Altered androgen hormone homeostasis and androgen receptor (AR) activity have been implicated in ovarian carcinogenesis but the relationship between AR expression in ovarian cancer and clinical outcome remains unclear.</p> <p>Methods</p> <p>In this study, the prognostic impact of AR expression was investigated using immunohistochemistry in tissue microarrays from 154 incident cases of epithelial ovarian cancer (EOC) in the prospective, population-based cohorts Malmö Diet and Cancer Study and Malmö Preventive Project. A subset of corresponding fallopian tubes (n = 36) with no histopathological evidence of disease was also analysed.</p> <p>Results</p> <p>While abundantly expressed in the majority of fallopian tubes with more than 75% positive nuclei in 16/36 (44%) cases, AR was absent in 108/154 (70%) of EOC cases. AR expression was not related to prognosis in the entire cohort, but in the serous subtype (n = 90), AR positivity (> 10% positive nuclei) was associated with a prolonged disease specific survival in univariate (HR= 0.49; 95% CI 0.25-0.96; p= 0.038) and multivariate (HR= 0.46; 95% CI 0.22-0.97; p= 0.042) analysis, adjusted for age, grade and clinical stage.</p> <p>Conclusions</p> <p>AR expression is considerably reduced in EOC as compared to fallopian tubes, and in EOC of the serous subtype, high AR expression is a favourable prognostic factor. These results indicate that assessment of AR expression might be of value for treatment stratification of EOC patients with serous ovarian carcinoma.</p>http://www.ovarianresearch.com/content/3/1/14 |
| spellingShingle | Nodin Björn Zendehrokh Nooreldin Brändstedt Jenny Nilsson Elise Manjer Jonas Brennan Donal J Jirström Karin Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival Journal of Ovarian Research |
| title | Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival |
| title_full | Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival |
| title_fullStr | Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival |
| title_full_unstemmed | Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival |
| title_short | Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival |
| title_sort | increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival |
| url | http://www.ovarianresearch.com/content/3/1/14 |
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