Evaluation of the therapeutic effect of coenzyme Q10 in patients with generalized vitiligo
Background: Vitiligo is a skin autoimmune disease that affects 0.1% to more than 8% of people in the world. About 50% of patients develop the disease before the age of 20. In this disease, melanocytes are destroyed in the skin, mucous membranes and retina. As a result, white spots appear on differen...
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| Format: | Article |
| Language: | fas |
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Tehran University of Medical Sciences
2022-07-01
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| Series: | Tehran University Medical Journal |
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| Online Access: | http://tumj.tums.ac.ir/article-1-11810-en.html |
| _version_ | 1811313987812327424 |
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| author | Mina Mir Nezami Hamid Hamidi Saeed Karimi Motaleb |
| author_facet | Mina Mir Nezami Hamid Hamidi Saeed Karimi Motaleb |
| author_sort | Mina Mir Nezami |
| collection | DOAJ |
| description | Background: Vitiligo is a skin autoimmune disease that affects 0.1% to more than 8% of people in the world. About 50% of patients develop the disease before the age of 20. In this disease, melanocytes are destroyed in the skin, mucous membranes and retina. As a result, white spots appear on different parts of the body. Studies have suggested the role of oxidative stress in vitiligo. Coenzyme Q10 is a specific lipophilic antioxidant. The aim of this study was to evaluate the therapeutic effect of coenzyme Q10 in patients with generalized vitiligo.
Methods: This study was a randomized, double-blind, clinical trial of patients with generalized vitiligo who had been referred to the dermatology clinics of Vali-e-Asr Hospital and Imam Reza Clinic in May-August 2016. The sampling method was random. Patients were treated with standard treatment, and the case groups in addition to standard treatment with tablets containing coenzyme Q10. Patients were evaluated for response at the first visit, 1 and 3 months after the start of treatment.
Results: The mean age of 50 patients was 26.2±4.3 years. The diameter of the largest depigmented patch decreased in both intervention (P=0.000) and control (P=0.001) groups during 3 months of treatment. The difference in the frequency of patients in the grade of repigmentation was significant at the end of the third month compared to the end of the first month of treatment in both intervention (P=0.01) and control (P=0.02) groups. At the end of the third month, the frequency of patients in both intervention group with 21 patients (76%) and the control group with 18 patients (72%) were more in grades 1 and 2, while at the end of the first month, the frequency of patients in both intervention groups with 23 patients (92%) and control with 23 patients (92%) was more in grades 0 and 1.
Conclusion: Adjuvant therapy with oral coenzyme Q10 has no effect on improving depigment patch in vitiligo. |
| first_indexed | 2024-04-13T11:04:04Z |
| format | Article |
| id | doaj.art-282bddbb218c4dffb1e9bafbb08c8104 |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-04-13T11:04:04Z |
| publishDate | 2022-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-282bddbb218c4dffb1e9bafbb08c81042022-12-22T02:49:19ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222022-07-01804286292Evaluation of the therapeutic effect of coenzyme Q10 in patients with generalized vitiligoMina Mir Nezami0Hamid Hamidi1Saeed Karimi Motaleb2 Background: Vitiligo is a skin autoimmune disease that affects 0.1% to more than 8% of people in the world. About 50% of patients develop the disease before the age of 20. In this disease, melanocytes are destroyed in the skin, mucous membranes and retina. As a result, white spots appear on different parts of the body. Studies have suggested the role of oxidative stress in vitiligo. Coenzyme Q10 is a specific lipophilic antioxidant. The aim of this study was to evaluate the therapeutic effect of coenzyme Q10 in patients with generalized vitiligo. Methods: This study was a randomized, double-blind, clinical trial of patients with generalized vitiligo who had been referred to the dermatology clinics of Vali-e-Asr Hospital and Imam Reza Clinic in May-August 2016. The sampling method was random. Patients were treated with standard treatment, and the case groups in addition to standard treatment with tablets containing coenzyme Q10. Patients were evaluated for response at the first visit, 1 and 3 months after the start of treatment. Results: The mean age of 50 patients was 26.2±4.3 years. The diameter of the largest depigmented patch decreased in both intervention (P=0.000) and control (P=0.001) groups during 3 months of treatment. The difference in the frequency of patients in the grade of repigmentation was significant at the end of the third month compared to the end of the first month of treatment in both intervention (P=0.01) and control (P=0.02) groups. At the end of the third month, the frequency of patients in both intervention group with 21 patients (76%) and the control group with 18 patients (72%) were more in grades 1 and 2, while at the end of the first month, the frequency of patients in both intervention groups with 23 patients (92%) and control with 23 patients (92%) was more in grades 0 and 1. Conclusion: Adjuvant therapy with oral coenzyme Q10 has no effect on improving depigment patch in vitiligo.http://tumj.tums.ac.ir/article-1-11810-en.htmlcoenzyme q10oxidative stressvitiligo. |
| spellingShingle | Mina Mir Nezami Hamid Hamidi Saeed Karimi Motaleb Evaluation of the therapeutic effect of coenzyme Q10 in patients with generalized vitiligo Tehran University Medical Journal coenzyme q10 oxidative stress vitiligo. |
| title | Evaluation of the therapeutic effect of coenzyme Q10
in patients with generalized vitiligo |
| title_full | Evaluation of the therapeutic effect of coenzyme Q10
in patients with generalized vitiligo |
| title_fullStr | Evaluation of the therapeutic effect of coenzyme Q10
in patients with generalized vitiligo |
| title_full_unstemmed | Evaluation of the therapeutic effect of coenzyme Q10
in patients with generalized vitiligo |
| title_short | Evaluation of the therapeutic effect of coenzyme Q10
in patients with generalized vitiligo |
| title_sort | evaluation of the therapeutic effect of coenzyme q10 in patients with generalized vitiligo |
| topic | coenzyme q10 oxidative stress vitiligo. |
| url | http://tumj.tums.ac.ir/article-1-11810-en.html |
| work_keys_str_mv | AT minamirnezami evaluationofthetherapeuticeffectofcoenzymeq10inpatientswithgeneralizedvitiligo AT hamidhamidi evaluationofthetherapeuticeffectofcoenzymeq10inpatientswithgeneralizedvitiligo AT saeedkarimimotaleb evaluationofthetherapeuticeffectofcoenzymeq10inpatientswithgeneralizedvitiligo |