Reduced gluconeogenesis and lactate clearance in Huntington's disease

Reduced gluconeogenesis and lactate clearance in Huntington's disease

We studied systemic and brain glucose and lactate metabolism in Huntington's disease (HD) patients in response to ergometer cycling. Following termination of exercise, blood glucose increased abruptly in control subjects, but no peak was seen in any of the HD patients (2.0±0.5 vs. 0.0±0.2 mM, P...

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Bibliographic Details
Main Authors: Knud Josefsen, Signe M.B. Nielsen, André Campos, Thomas Seifert, Lis Hasholt, Jørgen E. Nielsen, Anne Nørremølle, Niels H. Skotte, Niels H. Secher, Bjørn Quistorff
Format: Article
Language:English
Published: Elsevier 2010-12-01
Series:Neurobiology of Disease
Subjects:
Glucose
Exercise
Liver perfusion
Gluconeogenesis
Brain metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110002652

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