Site-activatable targeting of macromolecular alendronate for accelerated fracture healing
ABSTRACTSustainable social activity is a major goal in an aging society, although this is limited by loss of athleticism, with osteoporosis-related fractures being the most common cause of long-term behavioral restrictions in older people. Therefore, the development of therapeutics that shorten the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | Science and Technology of Advanced Materials |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/14686996.2023.2286218 |
| _version_ | 1797392783647965184 |
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| author | Makoto Matsui Yuka Kaihara Yuto Honda Nobuhiro Nishiyama Yutaka Miura |
| author_facet | Makoto Matsui Yuka Kaihara Yuto Honda Nobuhiro Nishiyama Yutaka Miura |
| author_sort | Makoto Matsui |
| collection | DOAJ |
| description | ABSTRACTSustainable social activity is a major goal in an aging society, although this is limited by loss of athleticism, with osteoporosis-related fractures being the most common cause of long-term behavioral restrictions in older people. Therefore, the development of therapeutics that shorten the duration of fracture therapy is essential to improve the quality of life and social activity of older individuals. In this study, we developed a polyethylene glycol-modified alendronate (PEG-ALN) that can efficiently deliver the active ingredient (ALN) to fracture sites. PEG-ALN released ALN in response to an acidic pH and was systemically administered to mice in a fracture model. PEG-ALN exhibited selective accumulation at the fracture site and significantly accelerated bone healing compared to free ALN. This study highlights the utility of a simple polymer modification of ALN as a systemically injectable medicine for patients with bone fractures. |
| first_indexed | 2024-03-08T23:53:28Z |
| format | Article |
| id | doaj.art-282d3ebd939e4173a9ad6ee74fb342bf |
| institution | Directory Open Access Journal |
| issn | 1468-6996 1878-5514 |
| language | English |
| last_indexed | 2024-03-08T23:53:28Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Science and Technology of Advanced Materials |
| spelling | doaj.art-282d3ebd939e4173a9ad6ee74fb342bf2023-12-13T09:35:32ZengTaylor & Francis GroupScience and Technology of Advanced Materials1468-69961878-55142023-12-0124110.1080/14686996.2023.2286218Site-activatable targeting of macromolecular alendronate for accelerated fracture healingMakoto Matsui0Yuka Kaihara1Yuto Honda2Nobuhiro Nishiyama3Yutaka Miura4Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, JapanLaboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, JapanLaboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, JapanLaboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, JapanLaboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, JapanABSTRACTSustainable social activity is a major goal in an aging society, although this is limited by loss of athleticism, with osteoporosis-related fractures being the most common cause of long-term behavioral restrictions in older people. Therefore, the development of therapeutics that shorten the duration of fracture therapy is essential to improve the quality of life and social activity of older individuals. In this study, we developed a polyethylene glycol-modified alendronate (PEG-ALN) that can efficiently deliver the active ingredient (ALN) to fracture sites. PEG-ALN released ALN in response to an acidic pH and was systemically administered to mice in a fracture model. PEG-ALN exhibited selective accumulation at the fracture site and significantly accelerated bone healing compared to free ALN. This study highlights the utility of a simple polymer modification of ALN as a systemically injectable medicine for patients with bone fractures.https://www.tandfonline.com/doi/10.1080/14686996.2023.2286218Bone fracturealendronateosteoporosisPEGylated drugosteoclast |
| spellingShingle | Makoto Matsui Yuka Kaihara Yuto Honda Nobuhiro Nishiyama Yutaka Miura Site-activatable targeting of macromolecular alendronate for accelerated fracture healing Science and Technology of Advanced Materials Bone fracture alendronate osteoporosis PEGylated drug osteoclast |
| title | Site-activatable targeting of macromolecular alendronate for accelerated fracture healing |
| title_full | Site-activatable targeting of macromolecular alendronate for accelerated fracture healing |
| title_fullStr | Site-activatable targeting of macromolecular alendronate for accelerated fracture healing |
| title_full_unstemmed | Site-activatable targeting of macromolecular alendronate for accelerated fracture healing |
| title_short | Site-activatable targeting of macromolecular alendronate for accelerated fracture healing |
| title_sort | site activatable targeting of macromolecular alendronate for accelerated fracture healing |
| topic | Bone fracture alendronate osteoporosis PEGylated drug osteoclast |
| url | https://www.tandfonline.com/doi/10.1080/14686996.2023.2286218 |
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