The Resection Rate of Synchronously Detected Liver and Lung Metastasis from Colorectal Cancer Is Low—A National Registry-Based Study
Population-based data on the incidence and surgical treatment of patients with colorectal cancer (CRC) and synchronous liver and lung metastases are lacking as are real-life data on the frequency of metastasectomy for both sites and outcomes in this setting. This is a nationwide population-based stu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/5/1434 |
| _version_ | 1797615637403533312 |
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| author | Jennie Engstrand Helena Taflin Jenny Lundmark Rystedt Oskar Hemmingsson Jozef Urdzik Per Sandström Bergthor Björnsson Kristina Hasselgren |
| author_facet | Jennie Engstrand Helena Taflin Jenny Lundmark Rystedt Oskar Hemmingsson Jozef Urdzik Per Sandström Bergthor Björnsson Kristina Hasselgren |
| author_sort | Jennie Engstrand |
| collection | DOAJ |
| description | Population-based data on the incidence and surgical treatment of patients with colorectal cancer (CRC) and synchronous liver and lung metastases are lacking as are real-life data on the frequency of metastasectomy for both sites and outcomes in this setting. This is a nationwide population-based study of all patients having liver and lung metastases diagnosed within 6 months of CRC between 2008 and 2016 in Sweden identified through the merging of data from the National Quality Registries on CRC, liver and thoracic surgery and the National Patient Registry. Among 60,734 patients diagnosed with CRC, 1923 (3.2%) had synchronous liver and lung metastases, of which 44 patients had complete metastasectomy. Surgery of liver and lung metastases yielded a 5-year OS of 74% (95% CI 57–85%) compared to 29% (95% CI 19–40%) if liver metastases were resected but not the lung metastases and 2.6% (95% CI 1.5–4%) if non-resected, <i>p</i> < 0.001. Complete resection rates ranged from 0.7% to 3.8% between the six healthcare regions of Sweden, <i>p</i> = 0.007. Synchronous liver and lung CRC metastases are rare, and a minority undergo the resection of both metastatic sites but with excellent survival. The reasons for differences in regional treatment approaches and the potential of increased resection rates should be studied further. |
| first_indexed | 2024-03-11T07:29:30Z |
| format | Article |
| id | doaj.art-282d468e3b9a44aeb382fbadff557a19 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T07:29:30Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-282d468e3b9a44aeb382fbadff557a192023-11-17T07:24:03ZengMDPI AGCancers2072-66942023-02-01155143410.3390/cancers15051434The Resection Rate of Synchronously Detected Liver and Lung Metastasis from Colorectal Cancer Is Low—A National Registry-Based StudyJennie Engstrand0Helena Taflin1Jenny Lundmark Rystedt2Oskar Hemmingsson3Jozef Urdzik4Per Sandström5Bergthor Björnsson6Kristina Hasselgren7Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Karolinska University Hospital, 141 86 Stockholm, SwedenDepartment of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, 413 45 Göteborg, SwedenDepartment of Surgery, Skåne University Hospital, Lund University, 221 00 Lund, SwedenDepartment of Surgical and Perioperative Sciences, Umeå University, 901 87 Umeå, SwedenDepartment of Surgical Sciences, Uppsala University, 752 36 Uppsala, SwedenDepartment of Surgery in Linköping, Linköping University, 581 83 Linköping, SwedenDepartment of Surgery in Linköping, Linköping University, 581 83 Linköping, SwedenDepartment of Surgery in Linköping, Linköping University, 581 83 Linköping, SwedenPopulation-based data on the incidence and surgical treatment of patients with colorectal cancer (CRC) and synchronous liver and lung metastases are lacking as are real-life data on the frequency of metastasectomy for both sites and outcomes in this setting. This is a nationwide population-based study of all patients having liver and lung metastases diagnosed within 6 months of CRC between 2008 and 2016 in Sweden identified through the merging of data from the National Quality Registries on CRC, liver and thoracic surgery and the National Patient Registry. Among 60,734 patients diagnosed with CRC, 1923 (3.2%) had synchronous liver and lung metastases, of which 44 patients had complete metastasectomy. Surgery of liver and lung metastases yielded a 5-year OS of 74% (95% CI 57–85%) compared to 29% (95% CI 19–40%) if liver metastases were resected but not the lung metastases and 2.6% (95% CI 1.5–4%) if non-resected, <i>p</i> < 0.001. Complete resection rates ranged from 0.7% to 3.8% between the six healthcare regions of Sweden, <i>p</i> = 0.007. Synchronous liver and lung CRC metastases are rare, and a minority undergo the resection of both metastatic sites but with excellent survival. The reasons for differences in regional treatment approaches and the potential of increased resection rates should be studied further.https://www.mdpi.com/2072-6694/15/5/1434liver metastaseslung metastasescolorectal cancersynchronous metastasesincidencetreatment |
| spellingShingle | Jennie Engstrand Helena Taflin Jenny Lundmark Rystedt Oskar Hemmingsson Jozef Urdzik Per Sandström Bergthor Björnsson Kristina Hasselgren The Resection Rate of Synchronously Detected Liver and Lung Metastasis from Colorectal Cancer Is Low—A National Registry-Based Study Cancers liver metastases lung metastases colorectal cancer synchronous metastases incidence treatment |
| title | The Resection Rate of Synchronously Detected Liver and Lung Metastasis from Colorectal Cancer Is Low—A National Registry-Based Study |
| title_full | The Resection Rate of Synchronously Detected Liver and Lung Metastasis from Colorectal Cancer Is Low—A National Registry-Based Study |
| title_fullStr | The Resection Rate of Synchronously Detected Liver and Lung Metastasis from Colorectal Cancer Is Low—A National Registry-Based Study |
| title_full_unstemmed | The Resection Rate of Synchronously Detected Liver and Lung Metastasis from Colorectal Cancer Is Low—A National Registry-Based Study |
| title_short | The Resection Rate of Synchronously Detected Liver and Lung Metastasis from Colorectal Cancer Is Low—A National Registry-Based Study |
| title_sort | resection rate of synchronously detected liver and lung metastasis from colorectal cancer is low a national registry based study |
| topic | liver metastases lung metastases colorectal cancer synchronous metastases incidence treatment |
| url | https://www.mdpi.com/2072-6694/15/5/1434 |
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