Assessment of Herpes Simplex Virus Type 1 and 2 by IHC in Association with CD14 Antigen in Placental Tissues from Women with Miscarriage
Among many viral causes of miscarriage, maternal infections caused by herpes simplex virus type -1 (HSV-1) and Herpes simplex virus type-2 (HSV-2) infections are important causes. CD14 was implicated in immune mechanisms, and might be involved in pregnancy loss. The aim of this study was to detect...
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| Format: | Article |
| Language: | English |
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Sulaimani Polytechnic University
2018-07-01
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| Series: | Kurdistan Journal of Applied Research |
| Subjects: | |
| Online Access: | https://www.kjar.spu.edu.iq/index.php/kjar/article/view/199 |
| _version_ | 1797193698245607424 |
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| author | Zainab A. Hamid Solaf J. Ali Ali Hattem Hussain |
| author_facet | Zainab A. Hamid Solaf J. Ali Ali Hattem Hussain |
| author_sort | Zainab A. Hamid |
| collection | DOAJ |
| description | Among many viral causes of miscarriage, maternal infections caused by herpes simplex virus type -1 (HSV-1) and Herpes simplex virus type-2 (HSV-2) infections are important causes. CD14 was implicated in immune mechanisms, and might be involved in pregnancy loss. The aim of this study was to detect the possible occurrence of two HSV-1 and HSV-2 infections as well as the immunological factor cd14 in placental tissues from patients with spontaneous abortion using immunohistochemistry techniques. Immunohistochemistry technique assay was used to detect placental infection with HSV-1& HSV-2 as well as CD14 in 40 women with spontaneous miscarriage and in 40 healthy deliveries in Baghdad/Iraq. The IHC- expressions of HSV-1, HSV-2, and CD14 proteins were detected in 4(10%), 15(37.5%), 15(37.5%) in placental tissues from miscarriage women, respectively. The association between CD14 with HSV-1 and HSV-2 among the placental tissues from miscarriage patients was constituting (5%), (20%) with HSV-1 & HSV-2, respectively. The considerable proportion of HSV-1, HSV-2, and infections found in the placental tissues from miscarriage women could drag the attention of obstetricians to implicate these viruses as possible targets in the etiology of spontaneous abortion case and there is possible association of CD14 with HSV-1 and HSV-2 in women with abortion.
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| first_indexed | 2024-03-07T15:25:30Z |
| format | Article |
| id | doaj.art-282da7866e094e98b56464a13cf4f2ed |
| institution | Directory Open Access Journal |
| issn | 2411-7684 2411-7706 |
| language | English |
| last_indexed | 2024-04-24T05:44:31Z |
| publishDate | 2018-07-01 |
| publisher | Sulaimani Polytechnic University |
| record_format | Article |
| series | Kurdistan Journal of Applied Research |
| spelling | doaj.art-282da7866e094e98b56464a13cf4f2ed2024-04-23T17:21:15ZengSulaimani Polytechnic UniversityKurdistan Journal of Applied Research2411-76842411-77062018-07-013210.24017/science.2018.2.11Assessment of Herpes Simplex Virus Type 1 and 2 by IHC in Association with CD14 Antigen in Placental Tissues from Women with MiscarriageZainab A. Hamid0Solaf J. Ali1Ali Hattem Hussain2Department of Microbiology, Baghdad Medical College, University of Baghdad, Baghdad, Iraq.Department of Community Health, Technical College of Health, Sulaimani Polytechnic University, Sulaimani, IraqDepartment of Community Health, Technical College of Health, Sulaimani Polytechnic University, Sulaimani, IraqAmong many viral causes of miscarriage, maternal infections caused by herpes simplex virus type -1 (HSV-1) and Herpes simplex virus type-2 (HSV-2) infections are important causes. CD14 was implicated in immune mechanisms, and might be involved in pregnancy loss. The aim of this study was to detect the possible occurrence of two HSV-1 and HSV-2 infections as well as the immunological factor cd14 in placental tissues from patients with spontaneous abortion using immunohistochemistry techniques. Immunohistochemistry technique assay was used to detect placental infection with HSV-1& HSV-2 as well as CD14 in 40 women with spontaneous miscarriage and in 40 healthy deliveries in Baghdad/Iraq. The IHC- expressions of HSV-1, HSV-2, and CD14 proteins were detected in 4(10%), 15(37.5%), 15(37.5%) in placental tissues from miscarriage women, respectively. The association between CD14 with HSV-1 and HSV-2 among the placental tissues from miscarriage patients was constituting (5%), (20%) with HSV-1 & HSV-2, respectively. The considerable proportion of HSV-1, HSV-2, and infections found in the placental tissues from miscarriage women could drag the attention of obstetricians to implicate these viruses as possible targets in the etiology of spontaneous abortion case and there is possible association of CD14 with HSV-1 and HSV-2 in women with abortion. https://www.kjar.spu.edu.iq/index.php/kjar/article/view/199Herpes viruses, Immunohistochemistry, Miscarriage, Pregnancy, Placenta, CD14. |
| spellingShingle | Zainab A. Hamid Solaf J. Ali Ali Hattem Hussain Assessment of Herpes Simplex Virus Type 1 and 2 by IHC in Association with CD14 Antigen in Placental Tissues from Women with Miscarriage Kurdistan Journal of Applied Research Herpes viruses, Immunohistochemistry, Miscarriage, Pregnancy, Placenta, CD14. |
| title | Assessment of Herpes Simplex Virus Type 1 and 2 by IHC in Association with CD14 Antigen in Placental Tissues from Women with Miscarriage |
| title_full | Assessment of Herpes Simplex Virus Type 1 and 2 by IHC in Association with CD14 Antigen in Placental Tissues from Women with Miscarriage |
| title_fullStr | Assessment of Herpes Simplex Virus Type 1 and 2 by IHC in Association with CD14 Antigen in Placental Tissues from Women with Miscarriage |
| title_full_unstemmed | Assessment of Herpes Simplex Virus Type 1 and 2 by IHC in Association with CD14 Antigen in Placental Tissues from Women with Miscarriage |
| title_short | Assessment of Herpes Simplex Virus Type 1 and 2 by IHC in Association with CD14 Antigen in Placental Tissues from Women with Miscarriage |
| title_sort | assessment of herpes simplex virus type 1 and 2 by ihc in association with cd14 antigen in placental tissues from women with miscarriage |
| topic | Herpes viruses, Immunohistochemistry, Miscarriage, Pregnancy, Placenta, CD14. |
| url | https://www.kjar.spu.edu.iq/index.php/kjar/article/view/199 |
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