| Summary: | Plants have been vital to human survival for aeons, especially for their unique medicinal properties. Trees of the <i>Eucalyptus</i> genus are well known for their medicinal properties; however, little is known of the ethnopharmacology and bioactivities of their close relatives in the <i>Corymbia</i> genus. Given the current lack of widespread knowledge of the <i>Corymbia</i> genus, this review aims to provide the first summary of the ethnopharmacology, phytochemistry and bioactivities of this genus. The Scopus, Web of Science, PubMed and Google Scholar databases were searched to identify research articles on the biological activities, phytochemistry and ethnomedical uses of <i>Corymbia</i> species. Of the 115 <i>Corymbia</i> species known, 14 species were found to have ethnomedical uses for the leaves, kino and/or bark. Analysis of the references obtained for these 14 <i>Corymbia</i> spp. revealed that the essential oils, crude extracts and compounds isolated from these species possess an array of biological activities including anti-bacterial, anti-fungal, anti-protozoal, anti-viral, larvicidal, insecticidal, acaricidal, anti-inflammatory, anti-oxidant, anti-cancer and anti-diabetic activities, highlighting the potential for this under-studied genus to provide lead compounds and treatments for a host of medical conditions.
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