Dual-tissue transplantation versus osteochondral autograft transplantation in the treatment of osteochondral defects: a porcine model study
Abstract Background Osteochondral injury is a common sports injury, and hyaline cartilage does not regenerate spontaneously when injured. However, there is currently no gold standard for treating osteochondral defects. Osteochondral autograft transplantation (OAT) is widely used in clinical practice...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-023-03964-6 |
| _version_ | 1797784473254756352 |
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| author | Rongmao Shi Gang Wang Zhian Chen Libo Yuan Tianhua Zhou Hongbo Tan |
| author_facet | Rongmao Shi Gang Wang Zhian Chen Libo Yuan Tianhua Zhou Hongbo Tan |
| author_sort | Rongmao Shi |
| collection | DOAJ |
| description | Abstract Background Osteochondral injury is a common sports injury, and hyaline cartilage does not regenerate spontaneously when injured. However, there is currently no gold standard for treating osteochondral defects. Osteochondral autograft transplantation (OAT) is widely used in clinical practice and is best used to treat small osteochondral lesions in the knee that are < 2 cm2 in size. Autologous dual-tissue transplantation (ADTT) is a promising method with wider indications for osteochondral injuries; however, ADTT has not been evaluated in many studies. This study aimed to compare the radiographic and histological results of ADTT and OAT for treating osteochondral defects in a porcine model. Methods Osteochondral defects were made in the bilateral medial condyles of the knees of 12 Dian-nan small-ear pigs. The 24 knees were divided into the ADTT group (n = 8), OAT group (n = 8), and empty control group (n = 8). At 2 and 4 months postoperatively, the knees underwent gross evaluation based on the International Cartilage Repair Society (ICRS) score, radiographic assessment based on CT findings and the magnetic resonance observation of cartilage repair tissue (MOCART) score, and histological evaluation based on the O'Driscoll histological score of the repair tissue. Results At 2 months postoperatively, the ICRS score, CT evaluation, MOCART score, and O'Driscoll histological score were significantly better in the OAT group than the ADTT group (all P < 0.05). At 4 months postoperatively, the ICRS score, CT evaluation, MOCART score, and O'Driscoll histological score tended to be better in the OAT group than the ADTT group, but these differences did not reach statistical significance (all P > 0.05). Conclusions In a porcine model, ADTT and OAT are both effective treatments for osteochondral defects in weight bearing areas. ADTT may be useful as an alternative procedure to OAT for treating osteochondral defects. |
| first_indexed | 2024-03-13T00:40:23Z |
| format | Article |
| id | doaj.art-282f29fcb6c944acaffc8aa0236ff7b1 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-03-13T00:40:23Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-282f29fcb6c944acaffc8aa0236ff7b12023-07-09T11:19:38ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2023-07-0118111210.1186/s13018-023-03964-6Dual-tissue transplantation versus osteochondral autograft transplantation in the treatment of osteochondral defects: a porcine model studyRongmao Shi0Gang Wang1Zhian Chen2Libo Yuan3Tianhua Zhou4Hongbo Tan5Department of Orthopaedic Surgery, 920th Hospital of Joint Logistics Support ForceDepartment of Orthopaedic Surgery, Xiangzhou Distract People’s HospitalDepartment of Orthopaedic Surgery, 920th Hospital of Joint Logistics Support ForceDepartment of Orthopaedic Surgery, 920th Hospital of Joint Logistics Support ForceDepartment of Orthopaedic Surgery, 920th Hospital of Joint Logistics Support ForceDepartment of Orthopaedic Surgery, 920th Hospital of Joint Logistics Support ForceAbstract Background Osteochondral injury is a common sports injury, and hyaline cartilage does not regenerate spontaneously when injured. However, there is currently no gold standard for treating osteochondral defects. Osteochondral autograft transplantation (OAT) is widely used in clinical practice and is best used to treat small osteochondral lesions in the knee that are < 2 cm2 in size. Autologous dual-tissue transplantation (ADTT) is a promising method with wider indications for osteochondral injuries; however, ADTT has not been evaluated in many studies. This study aimed to compare the radiographic and histological results of ADTT and OAT for treating osteochondral defects in a porcine model. Methods Osteochondral defects were made in the bilateral medial condyles of the knees of 12 Dian-nan small-ear pigs. The 24 knees were divided into the ADTT group (n = 8), OAT group (n = 8), and empty control group (n = 8). At 2 and 4 months postoperatively, the knees underwent gross evaluation based on the International Cartilage Repair Society (ICRS) score, radiographic assessment based on CT findings and the magnetic resonance observation of cartilage repair tissue (MOCART) score, and histological evaluation based on the O'Driscoll histological score of the repair tissue. Results At 2 months postoperatively, the ICRS score, CT evaluation, MOCART score, and O'Driscoll histological score were significantly better in the OAT group than the ADTT group (all P < 0.05). At 4 months postoperatively, the ICRS score, CT evaluation, MOCART score, and O'Driscoll histological score tended to be better in the OAT group than the ADTT group, but these differences did not reach statistical significance (all P > 0.05). Conclusions In a porcine model, ADTT and OAT are both effective treatments for osteochondral defects in weight bearing areas. ADTT may be useful as an alternative procedure to OAT for treating osteochondral defects.https://doi.org/10.1186/s13018-023-03964-6Osteochondral injuryArticular cartilageAnimal modelBone graftOsteochondral autograft transplantationAutologous cartilage chips |
| spellingShingle | Rongmao Shi Gang Wang Zhian Chen Libo Yuan Tianhua Zhou Hongbo Tan Dual-tissue transplantation versus osteochondral autograft transplantation in the treatment of osteochondral defects: a porcine model study Journal of Orthopaedic Surgery and Research Osteochondral injury Articular cartilage Animal model Bone graft Osteochondral autograft transplantation Autologous cartilage chips |
| title | Dual-tissue transplantation versus osteochondral autograft transplantation in the treatment of osteochondral defects: a porcine model study |
| title_full | Dual-tissue transplantation versus osteochondral autograft transplantation in the treatment of osteochondral defects: a porcine model study |
| title_fullStr | Dual-tissue transplantation versus osteochondral autograft transplantation in the treatment of osteochondral defects: a porcine model study |
| title_full_unstemmed | Dual-tissue transplantation versus osteochondral autograft transplantation in the treatment of osteochondral defects: a porcine model study |
| title_short | Dual-tissue transplantation versus osteochondral autograft transplantation in the treatment of osteochondral defects: a porcine model study |
| title_sort | dual tissue transplantation versus osteochondral autograft transplantation in the treatment of osteochondral defects a porcine model study |
| topic | Osteochondral injury Articular cartilage Animal model Bone graft Osteochondral autograft transplantation Autologous cartilage chips |
| url | https://doi.org/10.1186/s13018-023-03964-6 |
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