Changes in Gastric Microbial Composition before and after Eradication Therapy
Owing to advancements in next-generation sequencing and non-culture-based microbial research techniques, we have recognized that many bacterial taxa other than Helicobacter pylori (H. pylori) are present in the human stomach. Gastric microbial composition depends on gastric diseases, including gastr...
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| Format: | Article |
| Language: | English |
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Yong Chan Lee
2020-09-01
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| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| Subjects: | |
| Online Access: | http://www.helicojournal.org/upload/pdf/kjhugr-2020-0028.pdf |
| _version_ | 1819011300087300096 |
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| author | Chan Hyuk Park |
| author_facet | Chan Hyuk Park |
| author_sort | Chan Hyuk Park |
| collection | DOAJ |
| description | Owing to advancements in next-generation sequencing and non-culture-based microbial research techniques, we have recognized that many bacterial taxa other than Helicobacter pylori (H. pylori) are present in the human stomach. Gastric microbial composition depends on gastric diseases, including gastritis, atrophic gastritis, intestinal metaplasia, and gastric cancer. Although H. pylori is a major factor associated with gastric cancer development, other bacterial taxa may affect gastric carcinogenesis. Because the risk of gastric cancer development can be reduced through H. pylori eradication, many investigators have studied the changes in the microbial composition in the stomach after H. pylori eradication. The gastric microbiome in patients with H. pylori infection typically shows abundance of H. pylori and a low microbial diversity index. If we treat H. pylori-infected patients with antibiotics, microbial diversity increases, and the relative abundance also increases in many bacterial taxa. Several studies suggested that the microbial composition in patients with H. pylori infection could be restored by H. pylori eradication therapy; however, there have been inconsistent findings of the abundant bacterial taxa after H. pylori eradication in patients with atrophic gastritis and intestinal metaplasia. More studies are required to reach a definitive conclusion on restoration of the microbial composition after H. pylori eradication according to the severity of gastric inflammation. |
| first_indexed | 2024-12-21T01:25:58Z |
| format | Article |
| id | doaj.art-2830d053d139449bbe8fa89ec4149c88 |
| institution | Directory Open Access Journal |
| issn | 1738-3331 |
| language | English |
| last_indexed | 2024-12-21T01:25:58Z |
| publishDate | 2020-09-01 |
| publisher | Yong Chan Lee |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj.art-2830d053d139449bbe8fa89ec4149c882022-12-21T19:20:29ZengYong Chan LeeThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312020-09-0120317718610.7704/kjhugr.2020.0028643Changes in Gastric Microbial Composition before and after Eradication TherapyChan Hyuk Park0Department of Internal Medicine, Hanyang University College of Medicine, Seoul, KoreaOwing to advancements in next-generation sequencing and non-culture-based microbial research techniques, we have recognized that many bacterial taxa other than Helicobacter pylori (H. pylori) are present in the human stomach. Gastric microbial composition depends on gastric diseases, including gastritis, atrophic gastritis, intestinal metaplasia, and gastric cancer. Although H. pylori is a major factor associated with gastric cancer development, other bacterial taxa may affect gastric carcinogenesis. Because the risk of gastric cancer development can be reduced through H. pylori eradication, many investigators have studied the changes in the microbial composition in the stomach after H. pylori eradication. The gastric microbiome in patients with H. pylori infection typically shows abundance of H. pylori and a low microbial diversity index. If we treat H. pylori-infected patients with antibiotics, microbial diversity increases, and the relative abundance also increases in many bacterial taxa. Several studies suggested that the microbial composition in patients with H. pylori infection could be restored by H. pylori eradication therapy; however, there have been inconsistent findings of the abundant bacterial taxa after H. pylori eradication in patients with atrophic gastritis and intestinal metaplasia. More studies are required to reach a definitive conclusion on restoration of the microbial composition after H. pylori eradication according to the severity of gastric inflammation.http://www.helicojournal.org/upload/pdf/kjhugr-2020-0028.pdfmetagenomemicrobiota |
| spellingShingle | Chan Hyuk Park Changes in Gastric Microbial Composition before and after Eradication Therapy The Korean Journal of Helicobacter and Upper Gastrointestinal Research metagenome microbiota |
| title | Changes in Gastric Microbial Composition before and after Eradication Therapy |
| title_full | Changes in Gastric Microbial Composition before and after Eradication Therapy |
| title_fullStr | Changes in Gastric Microbial Composition before and after Eradication Therapy |
| title_full_unstemmed | Changes in Gastric Microbial Composition before and after Eradication Therapy |
| title_short | Changes in Gastric Microbial Composition before and after Eradication Therapy |
| title_sort | changes in gastric microbial composition before and after eradication therapy |
| topic | metagenome microbiota |
| url | http://www.helicojournal.org/upload/pdf/kjhugr-2020-0028.pdf |
| work_keys_str_mv | AT chanhyukpark changesingastricmicrobialcompositionbeforeandaftereradicationtherapy |