Therapeutic study of the nausea and vomiting caused by chemotherapy medications by olanzapine to triple antiemetic therapy in Iraqi cancer patients
Background:Chemotherapy-caused nausea and vomiting is a health problem in cancer patients. Olanzapine is used with serotonin receptor antagonists plus dexamethasone post Neurokinin 1 receptor antagonists as the antiemetic. Objective: The study aimed to determine the efficacy of (5 and 10) mg of...
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| Format: | Article |
| Language: | English |
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College of Pharmacy / Mustansiriyah University
2023-05-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1013 |
| _version_ | 1827293843631898624 |
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| author | Ghufran salah ahmed khadim ali khadim2 nabeel mudheher talib |
| author_facet | Ghufran salah ahmed khadim ali khadim2 nabeel mudheher talib |
| author_sort | Ghufran salah ahmed |
| collection | DOAJ |
| description |
Background:Chemotherapy-caused nausea and vomiting is a health problem in cancer patients. Olanzapine is used with serotonin receptor antagonists plus dexamethasone post Neurokinin 1 receptor antagonists as the antiemetic.
Objective: The study aimed to determine the efficacy of (5 and 10) mg of olanzapine with antiemetic drugs against chemotherapy-induced nausea and vomiting.
Methods: The study groups are Group S: received triple antiemetic therapy aprepitant at (1-3) day, dexamethasone at (1-4) day, and ondansetron only on the first day. Group O5: received olanzapine 5 mg with triple antiemetic therapy aprepitant (1-3) days, dexamethasone (1-4) day, ondansetron the first day, and olanzapine 5 mg (1-4) days. Group O10: received (olanzapine 10 mg with triple antiemetic therapy) aprepitant (1-3) days, dexamethasone (1-4) days, ondansetron day 1, and olanzapine 10 mg (1-4) days. The cancer was diagnosed by mamograph; the MAT score was used to control chemotherapy-caused nausea and vomiting.
Results: Higher acute and delayed nausea was observed in group S than in groups O5 and O10. Overall, nausea control was increased in group S than in groups O5 and O10. There was no significant difference between the different study groups.
Conclusion: Olanzapine 5 mg and 10 mg could treat nausea more than triple antiemetic in patients with nausea.
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| first_indexed | 2024-04-24T13:45:51Z |
| format | Article |
| id | doaj.art-28323078f2ef44e0beb2615395d2357b |
| institution | Directory Open Access Journal |
| issn | 1815-0993 2959-183X |
| language | English |
| last_indexed | 2024-04-24T13:45:51Z |
| publishDate | 2023-05-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj.art-28323078f2ef44e0beb2615395d2357b2024-04-04T06:20:56ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2023-05-0123210.32947/ajps.v23i2.1013Therapeutic study of the nausea and vomiting caused by chemotherapy medications by olanzapine to triple antiemetic therapy in Iraqi cancer patients Ghufran salah ahmed0khadim ali khadim21nabeel mudheher talib 2Clinical Pharmacy department/ College of Pharmacy/ Mustansiriyah University, Baghdad, Iraq Department of Clinical Pharmacy/College of Pharmacy/ Mustansiriyah University, Baghdad, Iraqdepartment of blood disease/Anbar cancer center,Al-Anbar,Iraq Background:Chemotherapy-caused nausea and vomiting is a health problem in cancer patients. Olanzapine is used with serotonin receptor antagonists plus dexamethasone post Neurokinin 1 receptor antagonists as the antiemetic. Objective: The study aimed to determine the efficacy of (5 and 10) mg of olanzapine with antiemetic drugs against chemotherapy-induced nausea and vomiting. Methods: The study groups are Group S: received triple antiemetic therapy aprepitant at (1-3) day, dexamethasone at (1-4) day, and ondansetron only on the first day. Group O5: received olanzapine 5 mg with triple antiemetic therapy aprepitant (1-3) days, dexamethasone (1-4) day, ondansetron the first day, and olanzapine 5 mg (1-4) days. Group O10: received (olanzapine 10 mg with triple antiemetic therapy) aprepitant (1-3) days, dexamethasone (1-4) days, ondansetron day 1, and olanzapine 10 mg (1-4) days. The cancer was diagnosed by mamograph; the MAT score was used to control chemotherapy-caused nausea and vomiting. Results: Higher acute and delayed nausea was observed in group S than in groups O5 and O10. Overall, nausea control was increased in group S than in groups O5 and O10. There was no significant difference between the different study groups. Conclusion: Olanzapine 5 mg and 10 mg could treat nausea more than triple antiemetic in patients with nausea. https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1013chemotherapy induced nausea and vomiting (CINV), olanzapine, (MASCC) antiemetic tool. |
| spellingShingle | Ghufran salah ahmed khadim ali khadim2 nabeel mudheher talib Therapeutic study of the nausea and vomiting caused by chemotherapy medications by olanzapine to triple antiemetic therapy in Iraqi cancer patients Al-Mustansiriyah Journal of Pharmaceutical Sciences chemotherapy induced nausea and vomiting (CINV), olanzapine, (MASCC) antiemetic tool. |
| title | Therapeutic study of the nausea and vomiting caused by chemotherapy medications by olanzapine to triple antiemetic therapy in Iraqi cancer patients |
| title_full | Therapeutic study of the nausea and vomiting caused by chemotherapy medications by olanzapine to triple antiemetic therapy in Iraqi cancer patients |
| title_fullStr | Therapeutic study of the nausea and vomiting caused by chemotherapy medications by olanzapine to triple antiemetic therapy in Iraqi cancer patients |
| title_full_unstemmed | Therapeutic study of the nausea and vomiting caused by chemotherapy medications by olanzapine to triple antiemetic therapy in Iraqi cancer patients |
| title_short | Therapeutic study of the nausea and vomiting caused by chemotherapy medications by olanzapine to triple antiemetic therapy in Iraqi cancer patients |
| title_sort | therapeutic study of the nausea and vomiting caused by chemotherapy medications by olanzapine to triple antiemetic therapy in iraqi cancer patients |
| topic | chemotherapy induced nausea and vomiting (CINV), olanzapine, (MASCC) antiemetic tool. |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1013 |
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