Paclitaxel-related dermatological problems: Not only alopecia occurs
Objective: Dermatological problems after chemotherapy are often neglected with gynecological oncologists. Since paclitaxel is one of most popular agents for gynecology organ-related cancers, dermatologic change after paclitaxel treatment is seldom reported before. Case report: Two patients with gyne...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-11-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455919302335 |
| _version_ | 1818196370469683200 |
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| author | Ming-Hsuan Su Guan-Yeu Chen Jun-Hung Lin Howard Hao Lee Kai-Cheng Chung Peng-Hui Wang |
| author_facet | Ming-Hsuan Su Guan-Yeu Chen Jun-Hung Lin Howard Hao Lee Kai-Cheng Chung Peng-Hui Wang |
| author_sort | Ming-Hsuan Su |
| collection | DOAJ |
| description | Objective: Dermatological problems after chemotherapy are often neglected with gynecological oncologists. Since paclitaxel is one of most popular agents for gynecology organ-related cancers, dermatologic change after paclitaxel treatment is seldom reported before. Case report: Two patients with gynecological organ malignancy who underwent the postoperative dose-dense weekly schedule of paclitaxel 80 mg/m2 plus carboplatin (area of curve 5) every three weeks had repeat dermatological problems (skull, facial and upper trunk areas) during the treatment. They included dermatitis, eczema, and folliculitis. Topical use of anti-fungal cream and oral anti-histamine agents stopped the disease progression and all had completed their chemotherapy without interruption. Conclusion: Clinicians should be aware of paclitaxel-induced skin toxicities, especially on the skull, face and upper trunk areas to minimize the occurrence of severe morbidity and to provide the better quality of life when cure is our primary priority in the management of gynecological organs-related malignancies. Keywords: Dermatological problems, Dose-dense chemotherapy, Folliculitis, Paclitaxel |
| first_indexed | 2024-12-12T01:33:00Z |
| format | Article |
| id | doaj.art-2832c0ef1ada4c61a65e39ad7323b009 |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-12T01:33:00Z |
| publishDate | 2019-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-2832c0ef1ada4c61a65e39ad7323b0092022-12-22T00:42:54ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592019-11-01586877879Paclitaxel-related dermatological problems: Not only alopecia occursMing-Hsuan Su0Guan-Yeu Chen1Jun-Hung Lin2Howard Hao Lee3Kai-Cheng Chung4Peng-Hui Wang5Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei, TaiwanDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei, TaiwanDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei, TaiwanDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei, TaiwanDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei, TaiwanDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; Female Cancer Foundation, Taipei, Taiwan; Corresponding author. Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, National Yang-Ming University, 201 Section 2, Shih-Pai Road, Taipei 11217, Taiwan. Fax: +886 255702788.Objective: Dermatological problems after chemotherapy are often neglected with gynecological oncologists. Since paclitaxel is one of most popular agents for gynecology organ-related cancers, dermatologic change after paclitaxel treatment is seldom reported before. Case report: Two patients with gynecological organ malignancy who underwent the postoperative dose-dense weekly schedule of paclitaxel 80 mg/m2 plus carboplatin (area of curve 5) every three weeks had repeat dermatological problems (skull, facial and upper trunk areas) during the treatment. They included dermatitis, eczema, and folliculitis. Topical use of anti-fungal cream and oral anti-histamine agents stopped the disease progression and all had completed their chemotherapy without interruption. Conclusion: Clinicians should be aware of paclitaxel-induced skin toxicities, especially on the skull, face and upper trunk areas to minimize the occurrence of severe morbidity and to provide the better quality of life when cure is our primary priority in the management of gynecological organs-related malignancies. Keywords: Dermatological problems, Dose-dense chemotherapy, Folliculitis, Paclitaxelhttp://www.sciencedirect.com/science/article/pii/S1028455919302335 |
| spellingShingle | Ming-Hsuan Su Guan-Yeu Chen Jun-Hung Lin Howard Hao Lee Kai-Cheng Chung Peng-Hui Wang Paclitaxel-related dermatological problems: Not only alopecia occurs Taiwanese Journal of Obstetrics & Gynecology |
| title | Paclitaxel-related dermatological problems: Not only alopecia occurs |
| title_full | Paclitaxel-related dermatological problems: Not only alopecia occurs |
| title_fullStr | Paclitaxel-related dermatological problems: Not only alopecia occurs |
| title_full_unstemmed | Paclitaxel-related dermatological problems: Not only alopecia occurs |
| title_short | Paclitaxel-related dermatological problems: Not only alopecia occurs |
| title_sort | paclitaxel related dermatological problems not only alopecia occurs |
| url | http://www.sciencedirect.com/science/article/pii/S1028455919302335 |
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