Heme-Oxygenase and Kidney Transplantation: A Potential for Target Therapy?
Kidney transplantation is a well-established therapy for patients with end-stage renal disease. While a significant improvement of short-term results has been achieved in the short-term, similar results were not reported in the long-term. Heme-oxygenase (HO) is the rate-limiting enzyme in heme catab...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/6/840 |
| _version_ | 1827715906186248192 |
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| author | Daniela Corona Burcin Ekser Rossella Gioco Massimo Caruso Chiara Schipa Pierfrancesco Veroux Alessia Giaquinta Antonio Granata Massimiliano Veroux |
| author_facet | Daniela Corona Burcin Ekser Rossella Gioco Massimo Caruso Chiara Schipa Pierfrancesco Veroux Alessia Giaquinta Antonio Granata Massimiliano Veroux |
| author_sort | Daniela Corona |
| collection | DOAJ |
| description | Kidney transplantation is a well-established therapy for patients with end-stage renal disease. While a significant improvement of short-term results has been achieved in the short-term, similar results were not reported in the long-term. Heme-oxygenase (HO) is the rate-limiting enzyme in heme catabolism, converting heme to iron, carbon monoxide, and biliverdin. Heme-oxygenase overexpression may be observed in all phases of transplant processes, including brain death, recipient management, and acute and chronic rejection. HO induction has been proved to provide a significant reduction of inflammatory response and a reduction of ischemia and reperfusion injury in organ transplantation, as well as providing a reduction of incidence of acute rejection. In this review, we will summarize data on HO and kidney transplantation, suggesting possible clinical applications in the near future to improve the long-term outcomes. |
| first_indexed | 2024-03-10T19:28:26Z |
| format | Article |
| id | doaj.art-2836859625284863b78271b73fcf16ce |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T19:28:26Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-2836859625284863b78271b73fcf16ce2023-11-20T02:17:55ZengMDPI AGBiomolecules2218-273X2020-05-0110684010.3390/biom10060840Heme-Oxygenase and Kidney Transplantation: A Potential for Target Therapy?Daniela Corona0Burcin Ekser1Rossella Gioco2Massimo Caruso3Chiara Schipa4Pierfrancesco Veroux5Alessia Giaquinta6Antonio Granata7Massimiliano Veroux8Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, ItalyDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46077, USAGeneral Surgery Unit, University Hospital of Catania, 95123 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, ItalyGeneral Surgery Unit, University Hospital of Catania, 95123 Catania, ItalyOrgan Transplant Unit, University Hospital of Catania, 95123 Catania, ItalyOrgan Transplant Unit, University Hospital of Catania, 95123 Catania, ItalyNephrology Unit, Cannizzaro Hospital, 95026 Catania, ItalyOrgan Transplant Unit, University Hospital of Catania, 95123 Catania, ItalyKidney transplantation is a well-established therapy for patients with end-stage renal disease. While a significant improvement of short-term results has been achieved in the short-term, similar results were not reported in the long-term. Heme-oxygenase (HO) is the rate-limiting enzyme in heme catabolism, converting heme to iron, carbon monoxide, and biliverdin. Heme-oxygenase overexpression may be observed in all phases of transplant processes, including brain death, recipient management, and acute and chronic rejection. HO induction has been proved to provide a significant reduction of inflammatory response and a reduction of ischemia and reperfusion injury in organ transplantation, as well as providing a reduction of incidence of acute rejection. In this review, we will summarize data on HO and kidney transplantation, suggesting possible clinical applications in the near future to improve the long-term outcomes.https://www.mdpi.com/2218-273X/10/6/840kidney transplantationdeceased donorliving donorheme-oxygenaseend-stage renal diseaseorgan transplantation |
| spellingShingle | Daniela Corona Burcin Ekser Rossella Gioco Massimo Caruso Chiara Schipa Pierfrancesco Veroux Alessia Giaquinta Antonio Granata Massimiliano Veroux Heme-Oxygenase and Kidney Transplantation: A Potential for Target Therapy? Biomolecules kidney transplantation deceased donor living donor heme-oxygenase end-stage renal disease organ transplantation |
| title | Heme-Oxygenase and Kidney Transplantation: A Potential for Target Therapy? |
| title_full | Heme-Oxygenase and Kidney Transplantation: A Potential for Target Therapy? |
| title_fullStr | Heme-Oxygenase and Kidney Transplantation: A Potential for Target Therapy? |
| title_full_unstemmed | Heme-Oxygenase and Kidney Transplantation: A Potential for Target Therapy? |
| title_short | Heme-Oxygenase and Kidney Transplantation: A Potential for Target Therapy? |
| title_sort | heme oxygenase and kidney transplantation a potential for target therapy |
| topic | kidney transplantation deceased donor living donor heme-oxygenase end-stage renal disease organ transplantation |
| url | https://www.mdpi.com/2218-273X/10/6/840 |
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