Microinvasive breast cancer and the role of sentinel lymph node biopsy
Abstract Whether sentinel lymph node biopsy (SLNB) should be performed in patients with microinvasive breast cancer (MIBC) has been a matter of debate over the last decade. MIBC has a favorable prognosis and while metastasis to the axilla is rare, it can impact treatment recommendations. In this stu...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-16521-8 |
| _version_ | 1828259709923098624 |
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| author | Sean M. Hacking Kara-Lynne Leonard Dongling Wu Mara Banks Theresa Graves Lijuan Wang Evgeny Yakirevich Yihong Wang |
| author_facet | Sean M. Hacking Kara-Lynne Leonard Dongling Wu Mara Banks Theresa Graves Lijuan Wang Evgeny Yakirevich Yihong Wang |
| author_sort | Sean M. Hacking |
| collection | DOAJ |
| description | Abstract Whether sentinel lymph node biopsy (SLNB) should be performed in patients with microinvasive breast cancer (MIBC) has been a matter of debate over the last decade. MIBC has a favorable prognosis and while metastasis to the axilla is rare, it can impact treatment recommendations. In this study we evaluated clinical and histological features in both MIBC and background DCIS including ER, PR, and HER-2, number of foci of MIBC, the extent of the DCIS, nuclear grade, presence of comedo necrosis, as well as surgical procedures, adjuvant treatment and follow up to identify variables which predict disease free survival (DFS), as well as the factors which influence clinical decision making. Our study included 72 MIBC patients with a mean patient follow-up time of 55 months. Three patients with MIBC had recurrence, and two deceased, leaving five patients in total with poor long-term outcomes and a DFS rate of 93.1%. Performing mastectomy, high nuclear grade, and negativity for ER and HER-2 were found to be associated with the use of SLNB, although none of these variables were found to be associated with DFS. One positive lymph node case was discovered following SLNB in our study. This suggests the use of SLNB may provide diagnostic information to some patients, although these are the anomalies. When comparing patients who had undergone SLNB to those which had not there was no difference in DFS. Certainly, the use of SLNB in MIBC is quite the conundrum. It is important to acknowledge that surgical complications have been reported, and traditional metrics used for risk assessment in invasive breast cancer may not hold true in the setting of microinvasion. |
| first_indexed | 2024-04-13T03:12:52Z |
| format | Article |
| id | doaj.art-283b51a7c20640669f0ead9e0bd1475c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T03:12:52Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-283b51a7c20640669f0ead9e0bd1475c2022-12-22T03:04:59ZengNature PortfolioScientific Reports2045-23222022-07-011211810.1038/s41598-022-16521-8Microinvasive breast cancer and the role of sentinel lymph node biopsySean M. Hacking0Kara-Lynne Leonard1Dongling Wu2Mara Banks3Theresa Graves4Lijuan Wang5Evgeny Yakirevich6Yihong Wang7Department of Pathology and Laboratory Medicine, Rhode Island Hospital and Lifespan Medical Center, Warren Alpert Medical School of Brown UniversityDepartment of Radiation Oncology, Rhode Island Hospital and Lifespan Medical Center, Warren Alpert Medical School of Brown UniversityDepartment of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellDepartment of Pathology and Laboratory Medicine, Rhode Island Hospital and Lifespan Medical Center, Warren Alpert Medical School of Brown UniversityDepartment of Surgery, Rhode Island Hospital and Lifespan Medical Center, Warren Alpert Medical School of Brown UniversityDepartment of Pathology and Laboratory Medicine, Rhode Island Hospital and Lifespan Medical Center, Warren Alpert Medical School of Brown UniversityDepartment of Pathology and Laboratory Medicine, Rhode Island Hospital and Lifespan Medical Center, Warren Alpert Medical School of Brown UniversityDepartment of Pathology and Laboratory Medicine, Rhode Island Hospital and Lifespan Medical Center, Warren Alpert Medical School of Brown UniversityAbstract Whether sentinel lymph node biopsy (SLNB) should be performed in patients with microinvasive breast cancer (MIBC) has been a matter of debate over the last decade. MIBC has a favorable prognosis and while metastasis to the axilla is rare, it can impact treatment recommendations. In this study we evaluated clinical and histological features in both MIBC and background DCIS including ER, PR, and HER-2, number of foci of MIBC, the extent of the DCIS, nuclear grade, presence of comedo necrosis, as well as surgical procedures, adjuvant treatment and follow up to identify variables which predict disease free survival (DFS), as well as the factors which influence clinical decision making. Our study included 72 MIBC patients with a mean patient follow-up time of 55 months. Three patients with MIBC had recurrence, and two deceased, leaving five patients in total with poor long-term outcomes and a DFS rate of 93.1%. Performing mastectomy, high nuclear grade, and negativity for ER and HER-2 were found to be associated with the use of SLNB, although none of these variables were found to be associated with DFS. One positive lymph node case was discovered following SLNB in our study. This suggests the use of SLNB may provide diagnostic information to some patients, although these are the anomalies. When comparing patients who had undergone SLNB to those which had not there was no difference in DFS. Certainly, the use of SLNB in MIBC is quite the conundrum. It is important to acknowledge that surgical complications have been reported, and traditional metrics used for risk assessment in invasive breast cancer may not hold true in the setting of microinvasion.https://doi.org/10.1038/s41598-022-16521-8 |
| spellingShingle | Sean M. Hacking Kara-Lynne Leonard Dongling Wu Mara Banks Theresa Graves Lijuan Wang Evgeny Yakirevich Yihong Wang Microinvasive breast cancer and the role of sentinel lymph node biopsy Scientific Reports |
| title | Microinvasive breast cancer and the role of sentinel lymph node biopsy |
| title_full | Microinvasive breast cancer and the role of sentinel lymph node biopsy |
| title_fullStr | Microinvasive breast cancer and the role of sentinel lymph node biopsy |
| title_full_unstemmed | Microinvasive breast cancer and the role of sentinel lymph node biopsy |
| title_short | Microinvasive breast cancer and the role of sentinel lymph node biopsy |
| title_sort | microinvasive breast cancer and the role of sentinel lymph node biopsy |
| url | https://doi.org/10.1038/s41598-022-16521-8 |
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