Natural killer cells: role in local tumor growth and metastasis
Inge Langers1,*, Virginie M Renoux1,*, Marc Thiry2, Philippe Delvenne1, Nathalie Jacobs1 1Laboratory of Experimental Pathology, GIGA-I3/GIGA-Cancer, University of Liège, 2Cellular and Tissular Biology, GIGA-Neurosciences, University of Liège, Liège, Belgi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2012-04-01
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| Series: | Biologics: Targets & Therapy |
| Online Access: | http://www.dovepress.com/natural-killer-cells-role-in-local-tumor-growth-and-metastasis-a9647 |
| _version_ | 1818856748366168064 |
|---|---|
| author | Langers I Renoux VM Thiry M Delvenne P Jacobs N |
| author_facet | Langers I Renoux VM Thiry M Delvenne P Jacobs N |
| author_sort | Langers I |
| collection | DOAJ |
| description | Inge Langers1,*, Virginie M Renoux1,*, Marc Thiry2, Philippe Delvenne1, Nathalie Jacobs1 1Laboratory of Experimental Pathology, GIGA-I3/GIGA-Cancer, University of Liège, 2Cellular and Tissular Biology, GIGA-Neurosciences, University of Liège, Liège, Belgium*These authors contributed equally to this workAbstract: Historically, the name of natural killer (NK) cells came from their natural ability to kill tumor cells in vitro. From the 1970s to date, accumulating data highlighted the importance of NK cells in host immune response against cancer and in therapy-induced antitumor response. The recognition and the lysis of tumor cells by NK cells are regulated by a complex balance of inhibitory and activating signals. This review summarizes NK cell mechanisms to kill cancer cells, their role in host immune responses against tumor growth or metastasis, and their implications in antitumor immunotherapies via cytokines, antibodies, or in combination with other therapies. The regulatory role of NK cells in autoimmunity is also discussed.Keywords: natural killer, tumor, cytotoxicity, natural cytotoxicity receptor |
| first_indexed | 2024-12-19T08:29:26Z |
| format | Article |
| id | doaj.art-283d85be7f96405a934e263e2e7ca2c7 |
| institution | Directory Open Access Journal |
| issn | 1177-5475 1177-5491 |
| language | English |
| last_indexed | 2024-12-19T08:29:26Z |
| publishDate | 2012-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Biologics: Targets & Therapy |
| spelling | doaj.art-283d85be7f96405a934e263e2e7ca2c72022-12-21T20:29:14ZengDove Medical PressBiologics: Targets & Therapy1177-54751177-54912012-04-012012default7382Natural killer cells: role in local tumor growth and metastasisLangers IRenoux VMThiry MDelvenne PJacobs NInge Langers1,*, Virginie M Renoux1,*, Marc Thiry2, Philippe Delvenne1, Nathalie Jacobs1 1Laboratory of Experimental Pathology, GIGA-I3/GIGA-Cancer, University of Liège, 2Cellular and Tissular Biology, GIGA-Neurosciences, University of Liège, Liège, Belgium*These authors contributed equally to this workAbstract: Historically, the name of natural killer (NK) cells came from their natural ability to kill tumor cells in vitro. From the 1970s to date, accumulating data highlighted the importance of NK cells in host immune response against cancer and in therapy-induced antitumor response. The recognition and the lysis of tumor cells by NK cells are regulated by a complex balance of inhibitory and activating signals. This review summarizes NK cell mechanisms to kill cancer cells, their role in host immune responses against tumor growth or metastasis, and their implications in antitumor immunotherapies via cytokines, antibodies, or in combination with other therapies. The regulatory role of NK cells in autoimmunity is also discussed.Keywords: natural killer, tumor, cytotoxicity, natural cytotoxicity receptorhttp://www.dovepress.com/natural-killer-cells-role-in-local-tumor-growth-and-metastasis-a9647 |
| spellingShingle | Langers I Renoux VM Thiry M Delvenne P Jacobs N Natural killer cells: role in local tumor growth and metastasis Biologics: Targets & Therapy |
| title | Natural killer cells: role in local tumor growth and metastasis |
| title_full | Natural killer cells: role in local tumor growth and metastasis |
| title_fullStr | Natural killer cells: role in local tumor growth and metastasis |
| title_full_unstemmed | Natural killer cells: role in local tumor growth and metastasis |
| title_short | Natural killer cells: role in local tumor growth and metastasis |
| title_sort | natural killer cells role in local tumor growth and metastasis |
| url | http://www.dovepress.com/natural-killer-cells-role-in-local-tumor-growth-and-metastasis-a9647 |
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