Textrous!: extracting semantic textual meaning from gene sets.
The un-biased and reproducible interpretation of high-content gene sets from large-scale genomic experiments is crucial to the understanding of biological themes, validation of experimental data, and the eventual development of plans for future experimentation. To derive biomedically-relevant inform...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3639949?pdf=render |
| _version_ | 1831691073753186304 |
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| author | Hongyu Chen Bronwen Martin Caitlin M Daimon Sana Siddiqui Louis M Luttrell Stuart Maudsley |
| author_facet | Hongyu Chen Bronwen Martin Caitlin M Daimon Sana Siddiqui Louis M Luttrell Stuart Maudsley |
| author_sort | Hongyu Chen |
| collection | DOAJ |
| description | The un-biased and reproducible interpretation of high-content gene sets from large-scale genomic experiments is crucial to the understanding of biological themes, validation of experimental data, and the eventual development of plans for future experimentation. To derive biomedically-relevant information from simple gene lists, a mathematical association to scientific language and meaningful words or sentences is crucial. Unfortunately, existing software for deriving meaningful and easily-appreciable scientific textual 'tokens' from large gene sets either rely on controlled vocabularies (Medical Subject Headings, Gene Ontology, BioCarta) or employ Boolean text searching and co-occurrence models that are incapable of detecting indirect links in the literature. As an improvement to existing web-based informatic tools, we have developed Textrous!, a web-based framework for the extraction of biomedical semantic meaning from a given input gene set of arbitrary length. Textrous! employs natural language processing techniques, including latent semantic indexing (LSI), sentence splitting, word tokenization, parts-of-speech tagging, and noun-phrase chunking, to mine MEDLINE abstracts, PubMed Central articles, articles from the Online Mendelian Inheritance in Man (OMIM), and Mammalian Phenotype annotation obtained from Jackson Laboratories. Textrous! has the ability to generate meaningful output data with even very small input datasets, using two different text extraction methodologies (collective and individual) for the selecting, ranking, clustering, and visualization of English words obtained from the user data. Textrous!, therefore, is able to facilitate the output of quantitatively significant and easily appreciable semantic words and phrases linked to both individual gene and batch genomic data. |
| first_indexed | 2024-12-20T11:24:10Z |
| format | Article |
| id | doaj.art-283dbe02c34d4c90acd3136d45ee634a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T11:24:10Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-283dbe02c34d4c90acd3136d45ee634a2022-12-21T19:42:26ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0184e6266510.1371/journal.pone.0062665Textrous!: extracting semantic textual meaning from gene sets.Hongyu ChenBronwen MartinCaitlin M DaimonSana SiddiquiLouis M LuttrellStuart MaudsleyThe un-biased and reproducible interpretation of high-content gene sets from large-scale genomic experiments is crucial to the understanding of biological themes, validation of experimental data, and the eventual development of plans for future experimentation. To derive biomedically-relevant information from simple gene lists, a mathematical association to scientific language and meaningful words or sentences is crucial. Unfortunately, existing software for deriving meaningful and easily-appreciable scientific textual 'tokens' from large gene sets either rely on controlled vocabularies (Medical Subject Headings, Gene Ontology, BioCarta) or employ Boolean text searching and co-occurrence models that are incapable of detecting indirect links in the literature. As an improvement to existing web-based informatic tools, we have developed Textrous!, a web-based framework for the extraction of biomedical semantic meaning from a given input gene set of arbitrary length. Textrous! employs natural language processing techniques, including latent semantic indexing (LSI), sentence splitting, word tokenization, parts-of-speech tagging, and noun-phrase chunking, to mine MEDLINE abstracts, PubMed Central articles, articles from the Online Mendelian Inheritance in Man (OMIM), and Mammalian Phenotype annotation obtained from Jackson Laboratories. Textrous! has the ability to generate meaningful output data with even very small input datasets, using two different text extraction methodologies (collective and individual) for the selecting, ranking, clustering, and visualization of English words obtained from the user data. Textrous!, therefore, is able to facilitate the output of quantitatively significant and easily appreciable semantic words and phrases linked to both individual gene and batch genomic data.http://europepmc.org/articles/PMC3639949?pdf=render |
| spellingShingle | Hongyu Chen Bronwen Martin Caitlin M Daimon Sana Siddiqui Louis M Luttrell Stuart Maudsley Textrous!: extracting semantic textual meaning from gene sets. PLoS ONE |
| title | Textrous!: extracting semantic textual meaning from gene sets. |
| title_full | Textrous!: extracting semantic textual meaning from gene sets. |
| title_fullStr | Textrous!: extracting semantic textual meaning from gene sets. |
| title_full_unstemmed | Textrous!: extracting semantic textual meaning from gene sets. |
| title_short | Textrous!: extracting semantic textual meaning from gene sets. |
| title_sort | textrous extracting semantic textual meaning from gene sets |
| url | http://europepmc.org/articles/PMC3639949?pdf=render |
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