Detailed Dissection of UBE3A-Mediated DDI1 Ubiquitination

Detailed Dissection of UBE3A-Mediated DDI1 Ubiquitination

The ubiquitin E3 ligase UBE3A has been widely reported to interact with the proteasome, but it is still unclear how this enzyme regulates by ubiquitination the different proteasomal subunits. The proteasome receptor DDI1 has been identified both in Drosophila photoreceptor neurons and in human neuro...

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Bibliographic Details
Main Authors: Nagore Elu, Nerea Osinalde, Javier Beaskoetxea, Juanma Ramirez, Benoit Lectez, Kerman Aloria, Jose Antonio Rodriguez, Jesus M. Arizmendi, Ugo Mayor
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Physiology
Subjects:
UBE3A
ubiquitin E3 ligase
Angelman syndrome
proteasome
mass-spectrometry
GFP pull-down
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00534/full

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