Subjective feelings associated with expectations and rewards during risky decision-making in impulse control disorder
Abstract Impulse Control Disorder (ICD) in Parkinson’s disease is a behavioral addiction induced by dopaminergic therapies, but otherwise unclear etiology. The current study investigates the interaction of reward processing variables, dopaminergic therapy, and risky decision-making and subjective fe...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-03-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-53076-2 |
| _version_ | 1797275196185378816 |
|---|---|
| author | Brittany Liebenow Angela Jiang Emily K. DiMarco L. Paul Sands Mary Moya-Mendez Adrian W. Laxton Mustafa S. Siddiqui Ihtsham ul Haq Kenneth T. Kishida |
| author_facet | Brittany Liebenow Angela Jiang Emily K. DiMarco L. Paul Sands Mary Moya-Mendez Adrian W. Laxton Mustafa S. Siddiqui Ihtsham ul Haq Kenneth T. Kishida |
| author_sort | Brittany Liebenow |
| collection | DOAJ |
| description | Abstract Impulse Control Disorder (ICD) in Parkinson’s disease is a behavioral addiction induced by dopaminergic therapies, but otherwise unclear etiology. The current study investigates the interaction of reward processing variables, dopaminergic therapy, and risky decision-making and subjective feelings in patients with versus without ICD. Patients with (n = 18) and without (n = 12) ICD performed a risky decision-making task both ‘on’ and ‘off’ standard-of-care dopaminergic therapies (the task was performed on 2 different days with the order of on and off visits randomized for each patient). During each trial of the task, participants choose between two options, a gamble or a certain reward, and reported how they felt about decision outcomes. Subjective feelings of ‘pleasure’ are differentially driven by expectations of possible outcomes in patients with, versus without ICD. While off medication, the influence of expectations about risky-decisions on subjective feelings is reduced in patients with ICD versus without ICD. While on medication, the influence of expected outcomes in patients with ICD versus without ICD becomes similar. Computational modeling of behavior supports the idea that latent decision-making factors drive subjective feelings in patients with Parkinson’s disease and that ICD status is associated with a change in the relationship between factors associated with risky behavior and subjective feelings about the experienced outcomes. Our results also suggest that dopaminergic medications modulate the impact expectations have on the participants' subjective reports. Altogether our results suggest that expectations about risky decisions may be decoupled from subjective feelings in patients with ICD, and that dopaminergic medications may reengage these circuits and increase emotional reactivity in patients with ICD. |
| first_indexed | 2024-03-07T15:09:53Z |
| format | Article |
| id | doaj.art-283fb407997245ceb2a70896a9a1a888 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:09:53Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-283fb407997245ceb2a70896a9a1a8882024-03-05T18:40:29ZengNature PortfolioScientific Reports2045-23222024-03-0114111310.1038/s41598-024-53076-2Subjective feelings associated with expectations and rewards during risky decision-making in impulse control disorderBrittany Liebenow0Angela Jiang1Emily K. DiMarco2L. Paul Sands3Mary Moya-Mendez4Adrian W. Laxton5Mustafa S. Siddiqui6Ihtsham ul Haq7Kenneth T. Kishida8Neuroscience Graduate Program, Wake Forest School of MedicineDepartment of Translational Neuroscience, Wake Forest School of MedicineNeuroscience Graduate Program, Wake Forest School of MedicineNeuroscience Graduate Program, Wake Forest School of MedicineDuke School of MedicineDepartment of Neurosurgery, Wake Forest School of MedicineDepartment of Neurology, Wake Forest School of MedicineDepartment of Neurology, University of Miami Miller School of MedicineNeuroscience Graduate Program, Wake Forest School of MedicineAbstract Impulse Control Disorder (ICD) in Parkinson’s disease is a behavioral addiction induced by dopaminergic therapies, but otherwise unclear etiology. The current study investigates the interaction of reward processing variables, dopaminergic therapy, and risky decision-making and subjective feelings in patients with versus without ICD. Patients with (n = 18) and without (n = 12) ICD performed a risky decision-making task both ‘on’ and ‘off’ standard-of-care dopaminergic therapies (the task was performed on 2 different days with the order of on and off visits randomized for each patient). During each trial of the task, participants choose between two options, a gamble or a certain reward, and reported how they felt about decision outcomes. Subjective feelings of ‘pleasure’ are differentially driven by expectations of possible outcomes in patients with, versus without ICD. While off medication, the influence of expectations about risky-decisions on subjective feelings is reduced in patients with ICD versus without ICD. While on medication, the influence of expected outcomes in patients with ICD versus without ICD becomes similar. Computational modeling of behavior supports the idea that latent decision-making factors drive subjective feelings in patients with Parkinson’s disease and that ICD status is associated with a change in the relationship between factors associated with risky behavior and subjective feelings about the experienced outcomes. Our results also suggest that dopaminergic medications modulate the impact expectations have on the participants' subjective reports. Altogether our results suggest that expectations about risky decisions may be decoupled from subjective feelings in patients with ICD, and that dopaminergic medications may reengage these circuits and increase emotional reactivity in patients with ICD.https://doi.org/10.1038/s41598-024-53076-2 |
| spellingShingle | Brittany Liebenow Angela Jiang Emily K. DiMarco L. Paul Sands Mary Moya-Mendez Adrian W. Laxton Mustafa S. Siddiqui Ihtsham ul Haq Kenneth T. Kishida Subjective feelings associated with expectations and rewards during risky decision-making in impulse control disorder Scientific Reports |
| title | Subjective feelings associated with expectations and rewards during risky decision-making in impulse control disorder |
| title_full | Subjective feelings associated with expectations and rewards during risky decision-making in impulse control disorder |
| title_fullStr | Subjective feelings associated with expectations and rewards during risky decision-making in impulse control disorder |
| title_full_unstemmed | Subjective feelings associated with expectations and rewards during risky decision-making in impulse control disorder |
| title_short | Subjective feelings associated with expectations and rewards during risky decision-making in impulse control disorder |
| title_sort | subjective feelings associated with expectations and rewards during risky decision making in impulse control disorder |
| url | https://doi.org/10.1038/s41598-024-53076-2 |
| work_keys_str_mv | AT brittanyliebenow subjectivefeelingsassociatedwithexpectationsandrewardsduringriskydecisionmakinginimpulsecontroldisorder AT angelajiang subjectivefeelingsassociatedwithexpectationsandrewardsduringriskydecisionmakinginimpulsecontroldisorder AT emilykdimarco subjectivefeelingsassociatedwithexpectationsandrewardsduringriskydecisionmakinginimpulsecontroldisorder AT lpaulsands subjectivefeelingsassociatedwithexpectationsandrewardsduringriskydecisionmakinginimpulsecontroldisorder AT marymoyamendez subjectivefeelingsassociatedwithexpectationsandrewardsduringriskydecisionmakinginimpulsecontroldisorder AT adrianwlaxton subjectivefeelingsassociatedwithexpectationsandrewardsduringriskydecisionmakinginimpulsecontroldisorder AT mustafassiddiqui subjectivefeelingsassociatedwithexpectationsandrewardsduringriskydecisionmakinginimpulsecontroldisorder AT ihtshamulhaq subjectivefeelingsassociatedwithexpectationsandrewardsduringriskydecisionmakinginimpulsecontroldisorder AT kennethtkishida subjectivefeelingsassociatedwithexpectationsandrewardsduringriskydecisionmakinginimpulsecontroldisorder |