Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) and anti-MRSA activities of extracts of some medicinal plants: A brief review
The increasing emergence of multidrug-resistant infection causing microorganisms has become a significant burden globally. Despite the efforts of pharmaceuticals in producing relatively new antimicrobial drugs, they have resulted in a high rate of mortality, disability and diseases across the world...
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| Format: | Article |
| Language: | English |
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AIMS Press
2019-04-01
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| Series: | AIMS Microbiology |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/10.3934/microbiol.2019.2.117/fulltext.html |
| _version_ | 1819027311794585600 |
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| author | Maureen U. Okwu Mitsan Olley Augustine O. Akpoka Osazee E. Izevbuwa |
| author_facet | Maureen U. Okwu Mitsan Olley Augustine O. Akpoka Osazee E. Izevbuwa |
| author_sort | Maureen U. Okwu |
| collection | DOAJ |
| description | The increasing emergence of multidrug-resistant infection causing microorganisms has become a significant burden globally. Despite the efforts of pharmaceuticals in producing relatively new antimicrobial drugs, they have resulted in a high rate of mortality, disability and diseases across the world especially in developing countries. Supporting this claim was the report of the Centre for Disease Control and Prevention (CDC) who estimated that over 2 million illnesses and 23,000 deaths per year are attributable to antibiotic resistant pathogens in the United States. They include Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA), Vancomycin-intermediate <em>Staphylococcus aureus</em> (VISA), Vancomycin-resistant <em>Staphylococcus aureus</em> (VRSA), Vancomycin-resistant enterococci (VRE), Extended spectrum beta-lactamases (ESBLs) producing gram-negative bacilli, Multidrug-resistant <em>Streptococcus pneumoniae</em> (MDRSP), Carbapenem-resistant Enterobacteriaceae (CRE) and Multidrug-resistant <em>Acinetobacter baumannii</em>. For MRSA, resistance is as a result of Methicillin-sensitive <em>S. aureus</em> (MSSA) strains that have acquired Staphylococcal Cassette Chromosome <em>mec</em> (SCC<em>mec</em>) which carries <em>mec</em>A gene. The gene encodes the penicillin-binding protein (PBP2a) which confers resistance to all β-lactam antibiotics. Vancomycin was previously the widely preferred drug for the treatment of MRSA infections. It is no longer the case with the emergence of <em>S. aureus</em> strains with reduced vancomycin sensitivity limiting the conventional treatment options for MRSA infections to very scanty expensive drugs. Presently, many researchers have reported the antibacterial activity of many plant extracts on MRSA. Hence, these medicinal plants might be promising candidates for treatment of MRSA infections. This work is a brief review on Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) and the anti-MRSA activities of extracts of selected medicinal plants. |
| first_indexed | 2024-12-21T05:40:28Z |
| format | Article |
| id | doaj.art-28400fcb2ad644c9979987438882bf33 |
| institution | Directory Open Access Journal |
| issn | 2471-1888 |
| language | English |
| last_indexed | 2024-12-21T05:40:28Z |
| publishDate | 2019-04-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Microbiology |
| spelling | doaj.art-28400fcb2ad644c9979987438882bf332022-12-21T19:14:17ZengAIMS PressAIMS Microbiology2471-18882019-04-015211713710.3934/microbiol.2019.2.117Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) and anti-MRSA activities of extracts of some medicinal plants: A brief reviewMaureen U. Okwu0Mitsan Olley1Augustine O. Akpoka2Osazee E. Izevbuwa31 Department of Biological Sciences, College of Natural and Applied Sciences, Igbinedion University Okada, Edo State, Nigeria2 Department of Pathology, Igbinedion University Teaching Hospital, Okada, Edo State, Nigeria1 Department of Biological Sciences, College of Natural and Applied Sciences, Igbinedion University Okada, Edo State, Nigeria1 Department of Biological Sciences, College of Natural and Applied Sciences, Igbinedion University Okada, Edo State, NigeriaThe increasing emergence of multidrug-resistant infection causing microorganisms has become a significant burden globally. Despite the efforts of pharmaceuticals in producing relatively new antimicrobial drugs, they have resulted in a high rate of mortality, disability and diseases across the world especially in developing countries. Supporting this claim was the report of the Centre for Disease Control and Prevention (CDC) who estimated that over 2 million illnesses and 23,000 deaths per year are attributable to antibiotic resistant pathogens in the United States. They include Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA), Vancomycin-intermediate <em>Staphylococcus aureus</em> (VISA), Vancomycin-resistant <em>Staphylococcus aureus</em> (VRSA), Vancomycin-resistant enterococci (VRE), Extended spectrum beta-lactamases (ESBLs) producing gram-negative bacilli, Multidrug-resistant <em>Streptococcus pneumoniae</em> (MDRSP), Carbapenem-resistant Enterobacteriaceae (CRE) and Multidrug-resistant <em>Acinetobacter baumannii</em>. For MRSA, resistance is as a result of Methicillin-sensitive <em>S. aureus</em> (MSSA) strains that have acquired Staphylococcal Cassette Chromosome <em>mec</em> (SCC<em>mec</em>) which carries <em>mec</em>A gene. The gene encodes the penicillin-binding protein (PBP2a) which confers resistance to all β-lactam antibiotics. Vancomycin was previously the widely preferred drug for the treatment of MRSA infections. It is no longer the case with the emergence of <em>S. aureus</em> strains with reduced vancomycin sensitivity limiting the conventional treatment options for MRSA infections to very scanty expensive drugs. Presently, many researchers have reported the antibacterial activity of many plant extracts on MRSA. Hence, these medicinal plants might be promising candidates for treatment of MRSA infections. This work is a brief review on Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) and the anti-MRSA activities of extracts of selected medicinal plants.https://www.aimspress.com/article/10.3934/microbiol.2019.2.117/fulltext.htmlmethicillin-resistant staphylococcus aureus (mrsa)vancomycin-intermediate s. aureus (visa)vancomycin-resistant s. aureus (vrsa)staphylococcal cassette chromosome mec (sccmec)anti-mrsa plants |
| spellingShingle | Maureen U. Okwu Mitsan Olley Augustine O. Akpoka Osazee E. Izevbuwa Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) and anti-MRSA activities of extracts of some medicinal plants: A brief review AIMS Microbiology methicillin-resistant staphylococcus aureus (mrsa) vancomycin-intermediate s. aureus (visa) vancomycin-resistant s. aureus (vrsa) staphylococcal cassette chromosome mec (sccmec) anti-mrsa plants |
| title | Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) and anti-MRSA activities of extracts of some medicinal plants: A brief review |
| title_full | Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) and anti-MRSA activities of extracts of some medicinal plants: A brief review |
| title_fullStr | Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) and anti-MRSA activities of extracts of some medicinal plants: A brief review |
| title_full_unstemmed | Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) and anti-MRSA activities of extracts of some medicinal plants: A brief review |
| title_short | Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) and anti-MRSA activities of extracts of some medicinal plants: A brief review |
| title_sort | methicillin resistant em staphylococcus aureus em mrsa and anti mrsa activities of extracts of some medicinal plants a brief review |
| topic | methicillin-resistant staphylococcus aureus (mrsa) vancomycin-intermediate s. aureus (visa) vancomycin-resistant s. aureus (vrsa) staphylococcal cassette chromosome mec (sccmec) anti-mrsa plants |
| url | https://www.aimspress.com/article/10.3934/microbiol.2019.2.117/fulltext.html |
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