Butoxy Mansonone G Inhibits STAT3 and Akt Signaling Pathways in Non-Small Cell Lung Cancers: Combined Experimental and Theoretical Investigations

Butoxy Mansonone G Inhibits STAT3 and Akt Signaling Pathways in Non-Small Cell Lung Cancers: Combined Experimental and Theoretical Investigations

Epidermal growth factor receptor (EGFR) is the key molecular target for non-small cell lung cancer (NSCLC) due to its major contribution to complex signaling cascades modulating the survival of cancer cells. Targeting EGFR-mediated signaling pathways has been proved as a potential strategy for NSCLC...

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Bibliographic Details
Main Authors: Panupong Mahalapbutr, Piyanuch Wonganan, Warinthorn Chavasiri, Thanyada Rungrotmongkol
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cancers
Subjects:
non-small cell lung cancer
mansonone G
apoptosis
STAT3
Akt
molecular dynamics simulation
Online Access:https://www.mdpi.com/2072-6694/11/4/437

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