Serial Changes in Blood-Cell-Count-Derived and CRP-Derived Inflammatory Indices of COVID-19 Patients
The aim of the study was to investigate the serial changes in inflammatory indices derived from blood cell counts and C-reactive protein (CRP) levels in COVID-19 patients with good and poor outcomes. We retrospectively analyzed the serial changes in the inflammatory indices in 169 COVID-19 patients....
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/4/746 |
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| author | Maryam B. Khadzhieva Alesya S. Gracheva Olesya B. Belopolskaya Yulia V. Chursinova Ivan V. Redkin Mikhail V. Pisarev Artem N. Kuzovlev |
| author_facet | Maryam B. Khadzhieva Alesya S. Gracheva Olesya B. Belopolskaya Yulia V. Chursinova Ivan V. Redkin Mikhail V. Pisarev Artem N. Kuzovlev |
| author_sort | Maryam B. Khadzhieva |
| collection | DOAJ |
| description | The aim of the study was to investigate the serial changes in inflammatory indices derived from blood cell counts and C-reactive protein (CRP) levels in COVID-19 patients with good and poor outcomes. We retrospectively analyzed the serial changes in the inflammatory indices in 169 COVID-19 patients. Comparative analyses were performed on the first and last days of a hospital stay or death and serially from day 1 to day 30 from the symptom onset. On admission, non-survivors had higher CRP to lymphocytes ratio (CLR) and multi-inflammatory index (MII) values than survivors, while at the time of discharge/death, the largest differences were found for the neutrophil to lymphocyte ratio (NLR), systemic inflammation response index (SIRI), and MII. A significant decrease in NLR, CLR, and MII by the time of discharge was documented in the survivors, and a significant increase in NLR was documented in the non-survivors. The NLR was the only one that remained significant from days 7–30 of disease in intergroup comparisons. The correlation between the indices and the outcome was observed starting from days 13–15. The changes in the index values over time proved to be more helpful in predicting COVID-19 outcomes than those measured on admission. The values of the inflammatory indices could reliably predict the outcome no earlier than days 13–15 of the disease. |
| first_indexed | 2024-03-11T08:56:39Z |
| format | Article |
| id | doaj.art-2843bd37013c4b549ba624a81d14049d |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T08:56:39Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-2843bd37013c4b549ba624a81d14049d2023-11-16T20:02:23ZengMDPI AGDiagnostics2075-44182023-02-0113474610.3390/diagnostics13040746Serial Changes in Blood-Cell-Count-Derived and CRP-Derived Inflammatory Indices of COVID-19 PatientsMaryam B. Khadzhieva0Alesya S. Gracheva1Olesya B. Belopolskaya2Yulia V. Chursinova3Ivan V. Redkin4Mikhail V. Pisarev5Artem N. Kuzovlev6Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 107031 Moscow, RussiaFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 107031 Moscow, RussiaResource Center “Bio-Bank Center”, Research Park of St. Petersburg State University, 198504 St. Petersburg, RussiaFederal Scientific and Clinical Center of Medical Rehabilitation and Balneology of the Federal Medical and Biological Agency of Russia, 127410 Moscow, RussiaFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 107031 Moscow, RussiaFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 107031 Moscow, RussiaFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 107031 Moscow, RussiaThe aim of the study was to investigate the serial changes in inflammatory indices derived from blood cell counts and C-reactive protein (CRP) levels in COVID-19 patients with good and poor outcomes. We retrospectively analyzed the serial changes in the inflammatory indices in 169 COVID-19 patients. Comparative analyses were performed on the first and last days of a hospital stay or death and serially from day 1 to day 30 from the symptom onset. On admission, non-survivors had higher CRP to lymphocytes ratio (CLR) and multi-inflammatory index (MII) values than survivors, while at the time of discharge/death, the largest differences were found for the neutrophil to lymphocyte ratio (NLR), systemic inflammation response index (SIRI), and MII. A significant decrease in NLR, CLR, and MII by the time of discharge was documented in the survivors, and a significant increase in NLR was documented in the non-survivors. The NLR was the only one that remained significant from days 7–30 of disease in intergroup comparisons. The correlation between the indices and the outcome was observed starting from days 13–15. The changes in the index values over time proved to be more helpful in predicting COVID-19 outcomes than those measured on admission. The values of the inflammatory indices could reliably predict the outcome no earlier than days 13–15 of the disease.https://www.mdpi.com/2075-4418/13/4/746COVID-19mortalityaggregate index of systemic inflammation (AISI)C-reactive protein to lymphocytes ratio (CLR)lymphocyte to monocyte ratio (LMR)multi-inflammatory index (MII) |
| spellingShingle | Maryam B. Khadzhieva Alesya S. Gracheva Olesya B. Belopolskaya Yulia V. Chursinova Ivan V. Redkin Mikhail V. Pisarev Artem N. Kuzovlev Serial Changes in Blood-Cell-Count-Derived and CRP-Derived Inflammatory Indices of COVID-19 Patients Diagnostics COVID-19 mortality aggregate index of systemic inflammation (AISI) C-reactive protein to lymphocytes ratio (CLR) lymphocyte to monocyte ratio (LMR) multi-inflammatory index (MII) |
| title | Serial Changes in Blood-Cell-Count-Derived and CRP-Derived Inflammatory Indices of COVID-19 Patients |
| title_full | Serial Changes in Blood-Cell-Count-Derived and CRP-Derived Inflammatory Indices of COVID-19 Patients |
| title_fullStr | Serial Changes in Blood-Cell-Count-Derived and CRP-Derived Inflammatory Indices of COVID-19 Patients |
| title_full_unstemmed | Serial Changes in Blood-Cell-Count-Derived and CRP-Derived Inflammatory Indices of COVID-19 Patients |
| title_short | Serial Changes in Blood-Cell-Count-Derived and CRP-Derived Inflammatory Indices of COVID-19 Patients |
| title_sort | serial changes in blood cell count derived and crp derived inflammatory indices of covid 19 patients |
| topic | COVID-19 mortality aggregate index of systemic inflammation (AISI) C-reactive protein to lymphocytes ratio (CLR) lymphocyte to monocyte ratio (LMR) multi-inflammatory index (MII) |
| url | https://www.mdpi.com/2075-4418/13/4/746 |
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