Mapping of proteomic lysate of a MCF-7 cancer cell line for the identification of potential markers for breast cancer
Mass spectrometric mapping of proteomic lysate of a MCF-7 cancer cell line was carried out, which identified 153 proteins having molecular weights of 5000 to 630000 Da, a high proportion of which was cytoplasmic and nuclear proteins. The latter accounted for 60 % of their total number whereas the pr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2014-07-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/91 |
| _version_ | 1797876130467807232 |
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| author | V. E. Shevchenko M. A. Taipov S. V. Kovalev N. E. Arnotskaya O. M. Pavlova I. A. Kudryavtsev Z. N. Nikiforova |
| author_facet | V. E. Shevchenko M. A. Taipov S. V. Kovalev N. E. Arnotskaya O. M. Pavlova I. A. Kudryavtsev Z. N. Nikiforova |
| author_sort | V. E. Shevchenko |
| collection | DOAJ |
| description | Mass spectrometric mapping of proteomic lysate of a MCF-7 cancer cell line was carried out, which identified 153 proteins having molecular weights of 5000 to 630000 Da, a high proportion of which was cytoplasmic and nuclear proteins. The latter accounted for 60 % of their total number whereas the proportion of extracellular and membrane proteins constituted 13 %. After using some selection criteria to analyze the findings, the authors present a list of 31 potential biomarkers and describe 12 promising breast anticancer therapeutic targets. |
| first_indexed | 2024-04-10T01:57:19Z |
| format | Article |
| id | doaj.art-2843f70f632b4c52b0ac271e7ea0f673 |
| institution | Directory Open Access Journal |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| last_indexed | 2024-04-10T01:57:19Z |
| publishDate | 2014-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj.art-2843f70f632b4c52b0ac271e7ea0f6732023-03-13T08:44:32ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272014-07-010241010.17650/1994-4098-2012-0-2-4-10106Mapping of proteomic lysate of a MCF-7 cancer cell line for the identification of potential markers for breast cancerV. E. Shevchenko0M. A. Taipov1S. V. Kovalev2N. E. Arnotskaya3O. M. Pavlova4I. A. Kudryavtsev5Z. N. Nikiforova6ФГБУ РОНЦ им. Н.Н. Блохина РАМН, МоскваФГБУ РОНЦ им. Н.Н. Блохина РАМН, МоскваФГБУ РОНЦ им. Н.Н. Блохина РАМН, МоскваФГБУ РОНЦ им. Н.Н. Блохина РАМН, МоскваФГБУ РОНЦ им. Н.Н. Блохина РАМН, МоскваФГБУ РОНЦ им. Н.Н. Блохина РАМН, МоскваФГБУ РОНЦ им. Н.Н. Блохина РАМН, МоскваMass spectrometric mapping of proteomic lysate of a MCF-7 cancer cell line was carried out, which identified 153 proteins having molecular weights of 5000 to 630000 Da, a high proportion of which was cytoplasmic and nuclear proteins. The latter accounted for 60 % of their total number whereas the proportion of extracellular and membrane proteins constituted 13 %. After using some selection criteria to analyze the findings, the authors present a list of 31 potential biomarkers and describe 12 promising breast anticancer therapeutic targets.https://ojrs.abvpress.ru/ojrs/article/view/91рак молочной железылиния опухолевых клеток mcf-7протеомикамасс-спектрометриябиомаркерымишени для таргетной терапии |
| spellingShingle | V. E. Shevchenko M. A. Taipov S. V. Kovalev N. E. Arnotskaya O. M. Pavlova I. A. Kudryavtsev Z. N. Nikiforova Mapping of proteomic lysate of a MCF-7 cancer cell line for the identification of potential markers for breast cancer Опухоли женской репродуктивной системы рак молочной железы линия опухолевых клеток mcf-7 протеомика масс-спектрометрия биомаркеры мишени для таргетной терапии |
| title | Mapping of proteomic lysate of a MCF-7 cancer cell line for the identification of potential markers for breast cancer |
| title_full | Mapping of proteomic lysate of a MCF-7 cancer cell line for the identification of potential markers for breast cancer |
| title_fullStr | Mapping of proteomic lysate of a MCF-7 cancer cell line for the identification of potential markers for breast cancer |
| title_full_unstemmed | Mapping of proteomic lysate of a MCF-7 cancer cell line for the identification of potential markers for breast cancer |
| title_short | Mapping of proteomic lysate of a MCF-7 cancer cell line for the identification of potential markers for breast cancer |
| title_sort | mapping of proteomic lysate of a mcf 7 cancer cell line for the identification of potential markers for breast cancer |
| topic | рак молочной железы линия опухолевых клеток mcf-7 протеомика масс-спектрометрия биомаркеры мишени для таргетной терапии |
| url | https://ojrs.abvpress.ru/ojrs/article/view/91 |
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