Further evidence to support acute and chronic anti-inflammatory effects of Nasturtium officinale
Background and purpose: Previously, we reported the anti-inflammatory properties of Nasturtium officinale (watercress) in several models of acute inflammation. This study was designed to explore the effects of topical and systemic administrations of N. officinale in the two chronic inflammatory mode...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Research in Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2022;volume=17;issue=3;spage=305;epage=314;aulast=Mostafazadeh |
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| author | Mostafa Mostafazadeh Heibatollah Sadeghi Hossein Sadeghi Vahid Zarezade Abolghasem Hadinia Esmaeel Panahi Kokhdan |
| author_facet | Mostafa Mostafazadeh Heibatollah Sadeghi Hossein Sadeghi Vahid Zarezade Abolghasem Hadinia Esmaeel Panahi Kokhdan |
| author_sort | Mostafa Mostafazadeh |
| collection | DOAJ |
| description | Background and purpose: Previously, we reported the anti-inflammatory properties of Nasturtium officinale (watercress) in several models of acute inflammation. This study was designed to explore the effects of topical and systemic administrations of N. officinale in the two chronic inflammatory models and to evaluate the role of TNF-α and IL-1β in these effects.
Experimental approach: Folin-Ciocalteu and aluminum chloride methods were used to estimate the extract’s total phenol and flavonoid content, respectively. Carrageenan-induced paw edema was carried out and TNF-α and IL-1β concentrations in the carrageenan-treated paw tissue were determined. Formalin injection into rat hind paws (7 days) and the application of 12-O-tetradecanoyl phorbol-13-acetate (TPA) on mouse ears (9 days) were used to simulate chronic inflammation. Furthermore, a histological assessment of the inflamed tissues was carried out.
Findings/Results: The extract’s flavonoid and phenolic contents were 90.26 ± 4.81 mg rutin equivalents/g and 68 ± 8.16 gallic acid equivalents/g gallic acid, respectively. N. officinale pretreatment in all doses administered considerably decreased carrageenan-induced edema. The extract also reduced IL-1β levels in carrageenan- treated paws while did not affect TNF-α levels. Oral and topical administrations of N. officinale considerably reserved the paw and ear edema. The extract also ameliorated the tissue injuries due to formalin and TPA challenges.
Conclusion and implications: The data confirmed the topical and systemic anti-inflammatory effects of watercress against two chronic models of inflammation. They suggested that these properties are not related to TNF-α but could be attributed to inhibition of IL-1β and inhibition of leukocyte infiltration. |
| first_indexed | 2024-12-10T10:06:34Z |
| format | Article |
| id | doaj.art-28443d072d87477b84880a3a384d927a |
| institution | Directory Open Access Journal |
| issn | 1735-5362 1735-9414 |
| language | English |
| last_indexed | 2024-12-10T10:06:34Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Research in Pharmaceutical Sciences |
| spelling | doaj.art-28443d072d87477b84880a3a384d927a2022-12-22T01:53:13ZengWolters Kluwer Medknow PublicationsResearch in Pharmaceutical Sciences1735-53621735-94142022-01-0117330531410.4103/1735-5362.343084Further evidence to support acute and chronic anti-inflammatory effects of Nasturtium officinaleMostafa MostafazadehHeibatollah SadeghiHossein SadeghiVahid ZarezadeAbolghasem HadiniaEsmaeel Panahi KokhdanBackground and purpose: Previously, we reported the anti-inflammatory properties of Nasturtium officinale (watercress) in several models of acute inflammation. This study was designed to explore the effects of topical and systemic administrations of N. officinale in the two chronic inflammatory models and to evaluate the role of TNF-α and IL-1β in these effects. Experimental approach: Folin-Ciocalteu and aluminum chloride methods were used to estimate the extract’s total phenol and flavonoid content, respectively. Carrageenan-induced paw edema was carried out and TNF-α and IL-1β concentrations in the carrageenan-treated paw tissue were determined. Formalin injection into rat hind paws (7 days) and the application of 12-O-tetradecanoyl phorbol-13-acetate (TPA) on mouse ears (9 days) were used to simulate chronic inflammation. Furthermore, a histological assessment of the inflamed tissues was carried out. Findings/Results: The extract’s flavonoid and phenolic contents were 90.26 ± 4.81 mg rutin equivalents/g and 68 ± 8.16 gallic acid equivalents/g gallic acid, respectively. N. officinale pretreatment in all doses administered considerably decreased carrageenan-induced edema. The extract also reduced IL-1β levels in carrageenan- treated paws while did not affect TNF-α levels. Oral and topical administrations of N. officinale considerably reserved the paw and ear edema. The extract also ameliorated the tissue injuries due to formalin and TPA challenges. Conclusion and implications: The data confirmed the topical and systemic anti-inflammatory effects of watercress against two chronic models of inflammation. They suggested that these properties are not related to TNF-α but could be attributed to inhibition of IL-1β and inhibition of leukocyte infiltration.http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2022;volume=17;issue=3;spage=305;epage=314;aulast=Mostafazadehanti-inflammatory; interleukin-1 beta; nasturtium officinale; tetradecanoyl phorbol acetate; tumor necrosis factor-alpha |
| spellingShingle | Mostafa Mostafazadeh Heibatollah Sadeghi Hossein Sadeghi Vahid Zarezade Abolghasem Hadinia Esmaeel Panahi Kokhdan Further evidence to support acute and chronic anti-inflammatory effects of Nasturtium officinale Research in Pharmaceutical Sciences anti-inflammatory; interleukin-1 beta; nasturtium officinale; tetradecanoyl phorbol acetate; tumor necrosis factor-alpha |
| title | Further evidence to support acute and chronic anti-inflammatory effects of Nasturtium officinale |
| title_full | Further evidence to support acute and chronic anti-inflammatory effects of Nasturtium officinale |
| title_fullStr | Further evidence to support acute and chronic anti-inflammatory effects of Nasturtium officinale |
| title_full_unstemmed | Further evidence to support acute and chronic anti-inflammatory effects of Nasturtium officinale |
| title_short | Further evidence to support acute and chronic anti-inflammatory effects of Nasturtium officinale |
| title_sort | further evidence to support acute and chronic anti inflammatory effects of nasturtium officinale |
| topic | anti-inflammatory; interleukin-1 beta; nasturtium officinale; tetradecanoyl phorbol acetate; tumor necrosis factor-alpha |
| url | http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2022;volume=17;issue=3;spage=305;epage=314;aulast=Mostafazadeh |
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