Lipid-rich histology in a basal-type immunoprofile breast carcinoma: histochemical and immunohistochemical analysis of a case
We describe the clinicopathological and morphological features of an unusual breast carcinoma classifiable as a lipid-rich variant of ductal invasive carcinoma, with a basal-type immunohistochemical profile. Basal-type breast cancers show no hormonal receptor expression, rarely over-express HER-2 bu...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2009-12-01
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| Series: | Rare Tumors |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/rt/article/view/1267 |
| _version_ | 1819010553601851392 |
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| author | Francesco Maria Maiello Joseph Sepe Giovanni Battista Giuseppe Pisani Paola Vinaccia Antonella Siciliano Serena Russo Diana Coppola Francesca Baldassarre |
| author_facet | Francesco Maria Maiello Joseph Sepe Giovanni Battista Giuseppe Pisani Paola Vinaccia Antonella Siciliano Serena Russo Diana Coppola Francesca Baldassarre |
| author_sort | Francesco Maria Maiello |
| collection | DOAJ |
| description | We describe the clinicopathological and morphological features of an unusual breast carcinoma classifiable as a lipid-rich variant of ductal invasive carcinoma, with a basal-type immunohistochemical profile. Basal-type breast cancers show no hormonal receptor expression, rarely over-express HER-2 but exhibit molecular high weight cytokeratins, EGFR and c-kit positivity. Special stains and histochemistry tests were used to elucidate the nature of vescicles in the neoplastic cells. Sudan IV was performed on formalin-fixed tissue. Commercially available antibodies tested were: ER, PgR, EGFR, HER2, c-kit, high molecular weight cytokeratins. Cytoplasmic lipids were highlighted as red-orange droplets on Sudan IV staining. As for immunohistochemistry, the tumor showed no reactivity to ER, PgR and HER2 (triple negative), and diffuse and strong positivity to high weight cytokeratins, EGFR and c-kit, such as a basal-type breast carcinoma. A basaloid phenotype in a lipid-rich carcinoma has not been previously reported. |
| first_indexed | 2024-12-21T01:14:06Z |
| format | Article |
| id | doaj.art-2844dfb92a394dd79ade6bdf2a02b46b |
| institution | Directory Open Access Journal |
| issn | 2036-3603 2036-3613 |
| language | English |
| last_indexed | 2024-12-21T01:14:06Z |
| publishDate | 2009-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Rare Tumors |
| spelling | doaj.art-2844dfb92a394dd79ade6bdf2a02b46b2022-12-21T19:20:49ZengSAGE PublishingRare Tumors2036-36032036-36132009-12-0112e41e4110.4081/rt.2009.e41Lipid-rich histology in a basal-type immunoprofile breast carcinoma: histochemical and immunohistochemical analysis of a caseFrancesco Maria MaielloJoseph SepeGiovanni BattistaGiuseppe PisaniPaola VinacciaAntonella SicilianoSerena RussoDiana CoppolaFrancesca BaldassarreWe describe the clinicopathological and morphological features of an unusual breast carcinoma classifiable as a lipid-rich variant of ductal invasive carcinoma, with a basal-type immunohistochemical profile. Basal-type breast cancers show no hormonal receptor expression, rarely over-express HER-2 but exhibit molecular high weight cytokeratins, EGFR and c-kit positivity. Special stains and histochemistry tests were used to elucidate the nature of vescicles in the neoplastic cells. Sudan IV was performed on formalin-fixed tissue. Commercially available antibodies tested were: ER, PgR, EGFR, HER2, c-kit, high molecular weight cytokeratins. Cytoplasmic lipids were highlighted as red-orange droplets on Sudan IV staining. As for immunohistochemistry, the tumor showed no reactivity to ER, PgR and HER2 (triple negative), and diffuse and strong positivity to high weight cytokeratins, EGFR and c-kit, such as a basal-type breast carcinoma. A basaloid phenotype in a lipid-rich carcinoma has not been previously reported.http://www.pagepress.org/journals/index.php/rt/article/view/1267Breast carcinoma – Basal type – EGFR – c-kit – Lipid-rich. |
| spellingShingle | Francesco Maria Maiello Joseph Sepe Giovanni Battista Giuseppe Pisani Paola Vinaccia Antonella Siciliano Serena Russo Diana Coppola Francesca Baldassarre Lipid-rich histology in a basal-type immunoprofile breast carcinoma: histochemical and immunohistochemical analysis of a case Rare Tumors Breast carcinoma – Basal type – EGFR – c-kit – Lipid-rich. |
| title | Lipid-rich histology in a basal-type immunoprofile breast carcinoma: histochemical and immunohistochemical analysis of a case |
| title_full | Lipid-rich histology in a basal-type immunoprofile breast carcinoma: histochemical and immunohistochemical analysis of a case |
| title_fullStr | Lipid-rich histology in a basal-type immunoprofile breast carcinoma: histochemical and immunohistochemical analysis of a case |
| title_full_unstemmed | Lipid-rich histology in a basal-type immunoprofile breast carcinoma: histochemical and immunohistochemical analysis of a case |
| title_short | Lipid-rich histology in a basal-type immunoprofile breast carcinoma: histochemical and immunohistochemical analysis of a case |
| title_sort | lipid rich histology in a basal type immunoprofile breast carcinoma histochemical and immunohistochemical analysis of a case |
| topic | Breast carcinoma – Basal type – EGFR – c-kit – Lipid-rich. |
| url | http://www.pagepress.org/journals/index.php/rt/article/view/1267 |
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