Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers
One of the great advancements in the applications of piezoelectric materials is the application for therapeutic medical ultrasound for sonothrombolysis. Sonothrombolysis is a promising ultrasound based technique to treat blood clots compared to conventional thrombolytic treatments or mechanical thro...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-02-01
|
| Series: | Sensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8220/20/5/1288 |
| _version_ | 1811262404318724096 |
|---|---|
| author | Leela Goel Xiaoning Jiang |
| author_facet | Leela Goel Xiaoning Jiang |
| author_sort | Leela Goel |
| collection | DOAJ |
| description | One of the great advancements in the applications of piezoelectric materials is the application for therapeutic medical ultrasound for sonothrombolysis. Sonothrombolysis is a promising ultrasound based technique to treat blood clots compared to conventional thrombolytic treatments or mechanical thrombectomy. Recent clinical trials using transcranial Doppler ultrasound, microbubble mediated sonothrombolysis, and catheter directed sonothrombolysis have shown promise. However, these conventional sonothrombolysis techniques still pose clinical safety limitations, preventing their application for standard of care. Recent advances in sonothrombolysis techniques including targeted and drug loaded microbubbles, phase change nanodroplets, high intensity focused ultrasound, histotripsy, and improved intravascular transducers, address some of the limitations of conventional sonothrombolysis treatments. Here, we review the strengths and limitations of these latest pre-clincial advancements for sonothrombolysis and their potential to improve clinical blood clot treatments. |
| first_indexed | 2024-04-12T19:24:41Z |
| format | Article |
| id | doaj.art-28456123edc34e47b3ad1534a86ef608 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-12T19:24:41Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-28456123edc34e47b3ad1534a86ef6082022-12-22T03:19:30ZengMDPI AGSensors1424-82202020-02-01205128810.3390/s20051288s20051288Advances in Sonothrombolysis Techniques Using Piezoelectric TransducersLeela Goel0Xiaoning Jiang1Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695-7910, USADepartment of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695-7910, USAOne of the great advancements in the applications of piezoelectric materials is the application for therapeutic medical ultrasound for sonothrombolysis. Sonothrombolysis is a promising ultrasound based technique to treat blood clots compared to conventional thrombolytic treatments or mechanical thrombectomy. Recent clinical trials using transcranial Doppler ultrasound, microbubble mediated sonothrombolysis, and catheter directed sonothrombolysis have shown promise. However, these conventional sonothrombolysis techniques still pose clinical safety limitations, preventing their application for standard of care. Recent advances in sonothrombolysis techniques including targeted and drug loaded microbubbles, phase change nanodroplets, high intensity focused ultrasound, histotripsy, and improved intravascular transducers, address some of the limitations of conventional sonothrombolysis treatments. Here, we review the strengths and limitations of these latest pre-clincial advancements for sonothrombolysis and their potential to improve clinical blood clot treatments.https://www.mdpi.com/1424-8220/20/5/1288sonothrombolysisultrasound enhanced thrombolysismicrobubblesultrasound contrast agentshigh intensity focused ultrasoundhistotripsyintravascular ultrasound |
| spellingShingle | Leela Goel Xiaoning Jiang Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers Sensors sonothrombolysis ultrasound enhanced thrombolysis microbubbles ultrasound contrast agents high intensity focused ultrasound histotripsy intravascular ultrasound |
| title | Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers |
| title_full | Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers |
| title_fullStr | Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers |
| title_full_unstemmed | Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers |
| title_short | Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers |
| title_sort | advances in sonothrombolysis techniques using piezoelectric transducers |
| topic | sonothrombolysis ultrasound enhanced thrombolysis microbubbles ultrasound contrast agents high intensity focused ultrasound histotripsy intravascular ultrasound |
| url | https://www.mdpi.com/1424-8220/20/5/1288 |
| work_keys_str_mv | AT leelagoel advancesinsonothrombolysistechniquesusingpiezoelectrictransducers AT xiaoningjiang advancesinsonothrombolysistechniquesusingpiezoelectrictransducers |