A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection
Master Regulator proteins, controlling the transcriptional identity of infected cells, can serve as drug targets for inhibiting virus replication, here demonstrated in a SARSCoV-2 infection model.
Bibliographic Details
| Main Authors: |
Pasquale Laise,
Megan L. Stanifer,
Gideon Bosker,
Xiaoyun Sun,
Sergio Triana,
Patricio Doldan,
Federico La Manna,
Marta De Menna,
Ronald B. Realubit,
Sergey Pampou,
Charles Karan,
Theodore Alexandrov,
Marianna Kruithof-de Julio,
Andrea Califano,
Steeve Boulant,
Mariano J. Alvarez |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-07-01
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| Series: | Communications Biology
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| Online Access: | https://doi.org/10.1038/s42003-022-03663-8
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