A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection
Master Regulator proteins, controlling the transcriptional identity of infected cells, can serve as drug targets for inhibiting virus replication, here demonstrated in a SARSCoV-2 infection model.
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03663-8 |
| _version_ | 1818192876550488064 |
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| author | Pasquale Laise Megan L. Stanifer Gideon Bosker Xiaoyun Sun Sergio Triana Patricio Doldan Federico La Manna Marta De Menna Ronald B. Realubit Sergey Pampou Charles Karan Theodore Alexandrov Marianna Kruithof-de Julio Andrea Califano Steeve Boulant Mariano J. Alvarez |
| author_facet | Pasquale Laise Megan L. Stanifer Gideon Bosker Xiaoyun Sun Sergio Triana Patricio Doldan Federico La Manna Marta De Menna Ronald B. Realubit Sergey Pampou Charles Karan Theodore Alexandrov Marianna Kruithof-de Julio Andrea Califano Steeve Boulant Mariano J. Alvarez |
| author_sort | Pasquale Laise |
| collection | DOAJ |
| description | Master Regulator proteins, controlling the transcriptional identity of infected cells, can serve as drug targets for inhibiting virus replication, here demonstrated in a SARSCoV-2 infection model. |
| first_indexed | 2024-12-12T00:37:28Z |
| format | Article |
| id | doaj.art-2848e83b0ed146a0b6c215d5176e0325 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-12T00:37:28Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-2848e83b0ed146a0b6c215d5176e03252022-12-22T00:44:19ZengNature PortfolioCommunications Biology2399-36422022-07-015111210.1038/s42003-022-03663-8A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infectionPasquale Laise0Megan L. Stanifer1Gideon Bosker2Xiaoyun Sun3Sergio Triana4Patricio Doldan5Federico La Manna6Marta De Menna7Ronald B. Realubit8Sergey Pampou9Charles Karan10Theodore Alexandrov11Marianna Kruithof-de Julio12Andrea Califano13Steeve Boulant14Mariano J. Alvarez15DarwinHealth IncDepartment of Infectious Diseases, Molecular Virology, Heidelberg University HospitalDarwinHealth IncDarwinHealth IncStructural and Computational Biology Unit, European Molecular Biology LaboratoryDepartment of Infectious Diseases, Virology, Heidelberg University HospitalDepartment for BioMedical Research, Urology Research Laboratory, University of BernDepartment for BioMedical Research, Urology Research Laboratory, University of BernDepartment of Systems Biology, Columbia University Irving Medical CenterDepartment of Systems Biology, Columbia University Irving Medical CenterDepartment of Systems Biology, Columbia University Irving Medical CenterStructural and Computational Biology Unit, European Molecular Biology LaboratoryDepartment for BioMedical Research, Urology Research Laboratory, University of BernDepartment of Systems Biology, Columbia University Irving Medical CenterDepartment of Molecular Genetics and Microbiology, University of Florida, College of MedicineDarwinHealth IncMaster Regulator proteins, controlling the transcriptional identity of infected cells, can serve as drug targets for inhibiting virus replication, here demonstrated in a SARSCoV-2 infection model.https://doi.org/10.1038/s42003-022-03663-8 |
| spellingShingle | Pasquale Laise Megan L. Stanifer Gideon Bosker Xiaoyun Sun Sergio Triana Patricio Doldan Federico La Manna Marta De Menna Ronald B. Realubit Sergey Pampou Charles Karan Theodore Alexandrov Marianna Kruithof-de Julio Andrea Califano Steeve Boulant Mariano J. Alvarez A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection Communications Biology |
| title | A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection |
| title_full | A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection |
| title_fullStr | A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection |
| title_full_unstemmed | A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection |
| title_short | A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection |
| title_sort | model for network based identification and pharmacological targeting of aberrant replication permissive transcriptional programs induced by viral infection |
| url | https://doi.org/10.1038/s42003-022-03663-8 |
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