The role of TIGAR in nervous system diseases
TP53-induced glycolysis and apoptosis regulator (TIGAR) mainly regulates pentose phosphate pathway by inhibiting glycolysis, so as to synthesize ribose required by DNA, promote DNA damage repair and cell proliferation, maintain cell homeostasis and avoid body injury. Its physiological functions incl...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1023161/full |
| _version_ | 1811231969999060992 |
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| author | Bei Huang Bei Huang Xiaoling Lang Xiaoling Lang Xihong Li Xihong Li |
| author_facet | Bei Huang Bei Huang Xiaoling Lang Xiaoling Lang Xihong Li Xihong Li |
| author_sort | Bei Huang |
| collection | DOAJ |
| description | TP53-induced glycolysis and apoptosis regulator (TIGAR) mainly regulates pentose phosphate pathway by inhibiting glycolysis, so as to synthesize ribose required by DNA, promote DNA damage repair and cell proliferation, maintain cell homeostasis and avoid body injury. Its physiological functions include anti-oxidative stress, reducing inflammation, maintaining mitochondrial function, inhibiting apoptosis, reducing autophagy etc. This paper reviews the research of TIGAR in neurological diseases, including stroke, Parkinson’s disease (PD), Alzheimer’s disease (AD), seizures and brain tumors, aiming to provide reference for the development of new therapeutic targets. |
| first_indexed | 2024-04-12T10:55:23Z |
| format | Article |
| id | doaj.art-284b00fa309f439c8e988f6aeacc0340 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-12T10:55:23Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-284b00fa309f439c8e988f6aeacc03402022-12-22T03:36:07ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-11-011410.3389/fnagi.2022.10231611023161The role of TIGAR in nervous system diseasesBei Huang0Bei Huang1Xiaoling Lang2Xiaoling Lang3Xihong Li4Xihong Li5West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaWest China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaWest China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaTP53-induced glycolysis and apoptosis regulator (TIGAR) mainly regulates pentose phosphate pathway by inhibiting glycolysis, so as to synthesize ribose required by DNA, promote DNA damage repair and cell proliferation, maintain cell homeostasis and avoid body injury. Its physiological functions include anti-oxidative stress, reducing inflammation, maintaining mitochondrial function, inhibiting apoptosis, reducing autophagy etc. This paper reviews the research of TIGAR in neurological diseases, including stroke, Parkinson’s disease (PD), Alzheimer’s disease (AD), seizures and brain tumors, aiming to provide reference for the development of new therapeutic targets.https://www.frontiersin.org/articles/10.3389/fnagi.2022.1023161/fullTIGARstrokePDADseizuresbrain tumors |
| spellingShingle | Bei Huang Bei Huang Xiaoling Lang Xiaoling Lang Xihong Li Xihong Li The role of TIGAR in nervous system diseases Frontiers in Aging Neuroscience TIGAR stroke PD AD seizures brain tumors |
| title | The role of TIGAR in nervous system diseases |
| title_full | The role of TIGAR in nervous system diseases |
| title_fullStr | The role of TIGAR in nervous system diseases |
| title_full_unstemmed | The role of TIGAR in nervous system diseases |
| title_short | The role of TIGAR in nervous system diseases |
| title_sort | role of tigar in nervous system diseases |
| topic | TIGAR stroke PD AD seizures brain tumors |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1023161/full |
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