Pax7 is necessary and sufficient for the myogenic specification of CD45+:Sca1+ stem cells from injured muscle.

Pax7 is necessary and sufficient for the myogenic specification of CD45+:Sca1+ stem cells from injured muscle.

CD45(+):Sca1(+) adult stem cells isolated from uninjured muscle do not display any myogenic potential, whereas those isolated from regenerating muscle give rise to myoblasts expressing the paired-box transcription factor Pax7 and the bHLH factors Myf5 and MyoD. By contrast, CD45(+):Sca1(+) isolated...

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Bibliographic Details
Main Authors:	Patrick Seale, Jeff Ishibashi, Anthony Scimè, Michael A Rudnicki
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2004-05-01
Series:	PLoS Biology
Online Access:	http://europepmc.org/articles/PMC406392?pdf=render

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