Medication history-wide association studies for pharmacovigilance of pregnant patients

Challa et al. used 2.8 million electronic health records for proactive pharmacovigilance program development, by rapidly generating and validating hypotheses between medication use during pregnancy and neonatal neurodevelopmental defects. They identify five drug classes for which deeper safety signa...

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Bibliographic Details
Main Authors: Anup P. Challa, Xinnan Niu, Etoi A. Garrison, Sara L. Van Driest, Lisa M. Bastarache, Ethan S. Lippmann, Robert R. Lavieri, Jeffery A. Goldstein, David M. Aronoff
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-022-00181-w
Description
Summary:Challa et al. used 2.8 million electronic health records for proactive pharmacovigilance program development, by rapidly generating and validating hypotheses between medication use during pregnancy and neonatal neurodevelopmental defects. They identify five drug classes for which deeper safety signal evaluation may improve product marketing.
ISSN:2730-664X