Loss of presenilin 2 age-dependently alters susceptibility to acute seizures and kindling acquisition

Loss of presenilin 2 age-dependently alters susceptibility to acute seizures and kindling acquisition

Patients with Alzheimer's disease (AD) experience seizures at higher rates than the general population of that age, suggesting an underexplored role of hyperexcitability in AD. Genetic variants in presenilin (PSEN) 1 and 2 genes lead to autosomal dominant early-onset AD (ADAD); patients with PS...

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Bibliographic Details
Main Authors: Megan Beckman, Kevin Knox, Zachery Koneval, Carole Smith, Suman Jayadev, Melissa Barker-Haliski
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Neurobiology of Disease
Subjects:
Seizures
Lamotrigine
Carbamazepine
Valproic acid
Levetiracetam
Diazepam
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119303948

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