Synergistic Strategies for Gastrointestinal Cancer Care: Unveiling the Benefits of Immunonutrition and Microbiota Modulation
Gastrointestinal (GI) cancers are a group of highly prevalent malignant tumors affecting the gastrointestinal tract. Globally, one in four cancer cases and one in three cancer deaths are estimated to be GI cancers. They can alter digestive and absorption functions, leading to severe malnutrition whi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/20/4408 |
| _version_ | 1797572702451531776 |
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| author | Serena Martinelli Ingrid Lamminpää Eda Nur Dübüş Dilara Sarıkaya Elena Niccolai |
| author_facet | Serena Martinelli Ingrid Lamminpää Eda Nur Dübüş Dilara Sarıkaya Elena Niccolai |
| author_sort | Serena Martinelli |
| collection | DOAJ |
| description | Gastrointestinal (GI) cancers are a group of highly prevalent malignant tumors affecting the gastrointestinal tract. Globally, one in four cancer cases and one in three cancer deaths are estimated to be GI cancers. They can alter digestive and absorption functions, leading to severe malnutrition which may worsen the prognosis of the patients. Therefore, nutritional intervention and monitoring play a fundamental role in managing metabolic alterations and cancer symptoms, as well as minimizing side effects and increasing the effectiveness of chemotherapy. In this scenario, the use of immunonutrients that are able to modulate the immune system and the modification/regulation of the gut microbiota composition have gained attention as a possible strategy to improve the conditions of these patients. The complex interaction between nutrients and microbiota might contribute to maintaining the homeostasis of each individual’s immune system; therefore, concurrent use of specific nutrients in combination with traditional cancer treatments may synergistically improve the overall care of GI cancer patients. This work aims to review and discuss the role of immunonutrition and microbiota modulation in improving nutritional status, postoperative recovery, and response to therapies in patients with GI cancer. |
| first_indexed | 2024-03-10T20:59:23Z |
| format | Article |
| id | doaj.art-284c71b0a1354174a716270ac73baeee |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T20:59:23Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-284c71b0a1354174a716270ac73baeee2023-11-19T17:38:23ZengMDPI AGNutrients2072-66432023-10-011520440810.3390/nu15204408Synergistic Strategies for Gastrointestinal Cancer Care: Unveiling the Benefits of Immunonutrition and Microbiota ModulationSerena Martinelli0Ingrid Lamminpää1Eda Nur Dübüş2Dilara Sarıkaya3Elena Niccolai4Department of Experimental and Clinical Medicine, University of Florence, 50134 Firenze, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Firenze, ItalyDepartment of Nutrition and Dietetics, Gazi University, 06560 Ankara, TurkeyDepartment of Nutrition and Dietetics, Gazi University, 06560 Ankara, TurkeyDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Firenze, ItalyGastrointestinal (GI) cancers are a group of highly prevalent malignant tumors affecting the gastrointestinal tract. Globally, one in four cancer cases and one in three cancer deaths are estimated to be GI cancers. They can alter digestive and absorption functions, leading to severe malnutrition which may worsen the prognosis of the patients. Therefore, nutritional intervention and monitoring play a fundamental role in managing metabolic alterations and cancer symptoms, as well as minimizing side effects and increasing the effectiveness of chemotherapy. In this scenario, the use of immunonutrients that are able to modulate the immune system and the modification/regulation of the gut microbiota composition have gained attention as a possible strategy to improve the conditions of these patients. The complex interaction between nutrients and microbiota might contribute to maintaining the homeostasis of each individual’s immune system; therefore, concurrent use of specific nutrients in combination with traditional cancer treatments may synergistically improve the overall care of GI cancer patients. This work aims to review and discuss the role of immunonutrition and microbiota modulation in improving nutritional status, postoperative recovery, and response to therapies in patients with GI cancer.https://www.mdpi.com/2072-6643/15/20/4408gastrointestinal cancersnutritional therapymicrobiotaimmunonutritionprobioticsimmunonutrients |
| spellingShingle | Serena Martinelli Ingrid Lamminpää Eda Nur Dübüş Dilara Sarıkaya Elena Niccolai Synergistic Strategies for Gastrointestinal Cancer Care: Unveiling the Benefits of Immunonutrition and Microbiota Modulation Nutrients gastrointestinal cancers nutritional therapy microbiota immunonutrition probiotics immunonutrients |
| title | Synergistic Strategies for Gastrointestinal Cancer Care: Unveiling the Benefits of Immunonutrition and Microbiota Modulation |
| title_full | Synergistic Strategies for Gastrointestinal Cancer Care: Unveiling the Benefits of Immunonutrition and Microbiota Modulation |
| title_fullStr | Synergistic Strategies for Gastrointestinal Cancer Care: Unveiling the Benefits of Immunonutrition and Microbiota Modulation |
| title_full_unstemmed | Synergistic Strategies for Gastrointestinal Cancer Care: Unveiling the Benefits of Immunonutrition and Microbiota Modulation |
| title_short | Synergistic Strategies for Gastrointestinal Cancer Care: Unveiling the Benefits of Immunonutrition and Microbiota Modulation |
| title_sort | synergistic strategies for gastrointestinal cancer care unveiling the benefits of immunonutrition and microbiota modulation |
| topic | gastrointestinal cancers nutritional therapy microbiota immunonutrition probiotics immunonutrients |
| url | https://www.mdpi.com/2072-6643/15/20/4408 |
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