Uncovering SOD3 and GPX4 as new targets of Benzo[α]pyrene-induced hepatotoxicity through Metabolomics and Chemical Proteomics

Uncovering SOD3 and GPX4 as new targets of Benzo[α]pyrene-induced hepatotoxicity through Metabolomics and Chemical Proteomics

Benzo[α]pyrene (Bap) is recognized as a ubiquitous environmental pollutant among the polycyclic aromatic hydrocarbons (PAHs) class. Previous studies have shown that the hepatotoxicity of Bap is mainly caused by its metabolites, although it remains unclear whether Bap itself induces such damage. This...

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Bibliographic Details
Main Authors: Yanwei Wang, Jiahui Zhao, Yipeng Xu, Cimin Tao, Jie Tong, Yingjie Luo, Yong Chen, Xuesong Liu, Tengfei Xu
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Redox Biology
Subjects:
Benzo[α]pyrene
Superoxide dismutase 3
Glutathione peroxidase 4
Metabolomics
Chemical proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723003312

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