LncRNA HCP5 knockdown inhibits high glucose-induced excessive proliferation, fibrosis and inflammation of human glomerular mesangial cells by regulating the miR-93-5p/HMGA2 axis

LncRNA HCP5 knockdown inhibits high glucose-induced excessive proliferation, fibrosis and inflammation of human glomerular mesangial cells by regulating the miR-93-5p/HMGA2 axis

Abstract Background Long non-coding RNAs (lncRNAs) are widely reported to be involved in the development of human diseases. HLA complex P5 (HCP5) deregulation is associated with various diseases. However, the function of HCP5 in diabetic nephropathy (DN) is unclear. Methods Human glomerular mesangia...

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Bibliographic Details
Main Authors: Xuan Wang, Yan Liu, Jian Rong, Kai Wang
Format: Article
Language:English
Published: BMC 2021-06-01
Series:BMC Endocrine Disorders
Subjects:
HCP5
miR-93-5p
HMGA2
Diabetic nephropathy
High glucose
Online Access:https://doi.org/10.1186/s12902-021-00781-y

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