Expression levels of caspase‐3 and gasdermin E and their involvement in the occurrence and prognosis of lung cancer
Abstract Background Pyroptosis plays a dual role in the development of cancer and malignancy; as such, it may potentially be a new target for cancer treatment. However, the inflammatory response to pyroptosis may have adverse effects on the body. The roles of gasdermin E (GSDME), caspases, and relat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-09-01
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| Series: | Cancer Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cnr2.1561 |
| _version_ | 1828113438944002048 |
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| author | Yuan‐Li Huang Guang‐Hui Zhang Qing Zhu Xia Wu Li‐Gao Wu |
| author_facet | Yuan‐Li Huang Guang‐Hui Zhang Qing Zhu Xia Wu Li‐Gao Wu |
| author_sort | Yuan‐Li Huang |
| collection | DOAJ |
| description | Abstract Background Pyroptosis plays a dual role in the development of cancer and malignancy; as such, it may potentially be a new target for cancer treatment. However, the inflammatory response to pyroptosis may have adverse effects on the body. The roles of gasdermin E (GSDME), caspases, and related proteins associated with pyroptosis in cancer remain controversial. Aim The goal of this study was to determine whether the expression levels of caspase‐3 and GSDME affect the clinical stage, pathological grade, or survival prognosis of patients with lung cancer. Methods We examined the protein levels of GSDME, caspase‐3, caspase‐8, and caspase‐9 in lung tissue samples from 100 patients with lung cancer by using immunohistochemistry. Results We found that GSDME, caspase‐3, and caspase‐8 were more highly expressed in tumor tissues than in adjacent normal tissues. Moreover, we found that GSDME could serve as a prognostic factor as there was a positive correlation between its expression level and the postoperative survival rate of patients with lung cancer. Conclusions GSDME may be an independent factor affecting the prognosis of patients with lung cancer. However, the role of GSDME and its related proteins in cancer requires further research. |
| first_indexed | 2024-04-11T12:07:05Z |
| format | Article |
| id | doaj.art-284e2f10c94d4bcfa5707a415ac37fe0 |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-04-11T12:07:05Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-284e2f10c94d4bcfa5707a415ac37fe02022-12-22T04:24:42ZengWileyCancer Reports2573-83482022-09-0159n/an/a10.1002/cnr2.1561Expression levels of caspase‐3 and gasdermin E and their involvement in the occurrence and prognosis of lung cancerYuan‐Li Huang0Guang‐Hui Zhang1Qing Zhu2Xia Wu3Li‐Gao Wu4Department of Pathology First Affiliated Hospital of Bengbu Medical College Bengbu Anhui ChinaDepartment of Pathology First Affiliated Hospital of Bengbu Medical College Bengbu Anhui ChinaDepartment of Pathology First Affiliated Hospital of Bengbu Medical College Bengbu Anhui ChinaDepartment of Pathology First Affiliated Hospital of Bengbu Medical College Bengbu Anhui ChinaDepartment of Pathology First Affiliated Hospital of Bengbu Medical College Bengbu Anhui ChinaAbstract Background Pyroptosis plays a dual role in the development of cancer and malignancy; as such, it may potentially be a new target for cancer treatment. However, the inflammatory response to pyroptosis may have adverse effects on the body. The roles of gasdermin E (GSDME), caspases, and related proteins associated with pyroptosis in cancer remain controversial. Aim The goal of this study was to determine whether the expression levels of caspase‐3 and GSDME affect the clinical stage, pathological grade, or survival prognosis of patients with lung cancer. Methods We examined the protein levels of GSDME, caspase‐3, caspase‐8, and caspase‐9 in lung tissue samples from 100 patients with lung cancer by using immunohistochemistry. Results We found that GSDME, caspase‐3, and caspase‐8 were more highly expressed in tumor tissues than in adjacent normal tissues. Moreover, we found that GSDME could serve as a prognostic factor as there was a positive correlation between its expression level and the postoperative survival rate of patients with lung cancer. Conclusions GSDME may be an independent factor affecting the prognosis of patients with lung cancer. However, the role of GSDME and its related proteins in cancer requires further research.https://doi.org/10.1002/cnr2.1561caspase‐8immunohistochemistryinflammatorypyroptosissurvival rate |
| spellingShingle | Yuan‐Li Huang Guang‐Hui Zhang Qing Zhu Xia Wu Li‐Gao Wu Expression levels of caspase‐3 and gasdermin E and their involvement in the occurrence and prognosis of lung cancer Cancer Reports caspase‐8 immunohistochemistry inflammatory pyroptosis survival rate |
| title | Expression levels of caspase‐3 and gasdermin E and their involvement in the occurrence and prognosis of lung cancer |
| title_full | Expression levels of caspase‐3 and gasdermin E and their involvement in the occurrence and prognosis of lung cancer |
| title_fullStr | Expression levels of caspase‐3 and gasdermin E and their involvement in the occurrence and prognosis of lung cancer |
| title_full_unstemmed | Expression levels of caspase‐3 and gasdermin E and their involvement in the occurrence and prognosis of lung cancer |
| title_short | Expression levels of caspase‐3 and gasdermin E and their involvement in the occurrence and prognosis of lung cancer |
| title_sort | expression levels of caspase 3 and gasdermin e and their involvement in the occurrence and prognosis of lung cancer |
| topic | caspase‐8 immunohistochemistry inflammatory pyroptosis survival rate |
| url | https://doi.org/10.1002/cnr2.1561 |
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