Relationship between acute kidney injury, seasonal influenza, and environmental factors: A 14-year retrospective analysis
Despite high incidence of acute kidney injury (AKI) among patients hospitalised for influenza, no previous work has attempted to analyse and quantify the association between the two. Herein, we made use of Hong Kong's surveillance data to evaluate the time-varying relationship between seasonal...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-08-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S016041202100146X |
| _version_ | 1818437845264629760 |
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| author | Kirran N. Mohammad Emily Ying Yang Chan Steven Yuk-Fai Lau Holly Ching Yu Lam William Bernard Goggins Ka Chun Chong |
| author_facet | Kirran N. Mohammad Emily Ying Yang Chan Steven Yuk-Fai Lau Holly Ching Yu Lam William Bernard Goggins Ka Chun Chong |
| author_sort | Kirran N. Mohammad |
| collection | DOAJ |
| description | Despite high incidence of acute kidney injury (AKI) among patients hospitalised for influenza, no previous work has attempted to analyse and quantify the association between the two. Herein, we made use of Hong Kong's surveillance data to evaluate the time-varying relationship between seasonal influenza and risk of AKI with adjustment for potential environmental covariates. Generalized additive model was used in conjunction with distributed-lag non-linear model to estimate the association of interest with daily AKI admissions as outcome and daily influenza admissions as predictor, while controlling for environmental variables (i.e. temperature, relative humidity, total rainfall, nitrogen dioxide, and ozone). Results suggested a positive association between risk of AKI admission and number of influenza hospitalisation cases, with relative risk reaching 1.12 (95% confidence interval, 1.10–1.15) at the 95th percentile. Using median as reference, an almost U-shaped association between risk of AKI admission and temperature was observed; the risk increased significantly when the temperature was low. While ozone was not shown to be a risk factor for AKI, moderate-to-high levels of nitrogen dioxide (50–95th percentile) were significantly associated with increased risk of AKI admission. This study mentioned the possibility that AKI hospitalisations are subject to environmental influences and offered support for a positive association between seasonal influenza and AKI occurrence in Hong Kong. Authorities are urged to extend the influenza vaccination program to individuals with pre-existing renal conditions to safeguard the health of the vulnerable. Given that adverse health effects are evident at current ambient levels of nitrogen dioxide, the government is recommended to adopt clean-air policies at the earliest opportunity to protect the health of the community. |
| first_indexed | 2024-12-14T17:31:08Z |
| format | Article |
| id | doaj.art-284ff4ef17594fd38bd5aaf1b0d1c970 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-14T17:31:08Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-284ff4ef17594fd38bd5aaf1b0d1c9702022-12-21T22:53:06ZengElsevierEnvironment International0160-41202021-08-01153106521Relationship between acute kidney injury, seasonal influenza, and environmental factors: A 14-year retrospective analysisKirran N. Mohammad0Emily Ying Yang Chan1Steven Yuk-Fai Lau2Holly Ching Yu Lam3William Bernard Goggins4Ka Chun Chong5School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, ChinaSchool of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, ChinaSchool of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, ChinaNational Heart & Lung Institute, Faculty of Medicine, Imperial College London, London, United KingdomSchool of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, ChinaSchool of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China; Clinical Trials and Biostatistics Laboratory, Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China; Centre for Health System and Policy Research, The Chinese University of Hong Kong, Hong Kong, China; Corresponding author at: Rm501, School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.Despite high incidence of acute kidney injury (AKI) among patients hospitalised for influenza, no previous work has attempted to analyse and quantify the association between the two. Herein, we made use of Hong Kong's surveillance data to evaluate the time-varying relationship between seasonal influenza and risk of AKI with adjustment for potential environmental covariates. Generalized additive model was used in conjunction with distributed-lag non-linear model to estimate the association of interest with daily AKI admissions as outcome and daily influenza admissions as predictor, while controlling for environmental variables (i.e. temperature, relative humidity, total rainfall, nitrogen dioxide, and ozone). Results suggested a positive association between risk of AKI admission and number of influenza hospitalisation cases, with relative risk reaching 1.12 (95% confidence interval, 1.10–1.15) at the 95th percentile. Using median as reference, an almost U-shaped association between risk of AKI admission and temperature was observed; the risk increased significantly when the temperature was low. While ozone was not shown to be a risk factor for AKI, moderate-to-high levels of nitrogen dioxide (50–95th percentile) were significantly associated with increased risk of AKI admission. This study mentioned the possibility that AKI hospitalisations are subject to environmental influences and offered support for a positive association between seasonal influenza and AKI occurrence in Hong Kong. Authorities are urged to extend the influenza vaccination program to individuals with pre-existing renal conditions to safeguard the health of the vulnerable. Given that adverse health effects are evident at current ambient levels of nitrogen dioxide, the government is recommended to adopt clean-air policies at the earliest opportunity to protect the health of the community.http://www.sciencedirect.com/science/article/pii/S016041202100146XAcute kidney injurySeasonal influenzaAmbient temperatureAir pollutionDistributed-lag non-linear modelSubtropics |
| spellingShingle | Kirran N. Mohammad Emily Ying Yang Chan Steven Yuk-Fai Lau Holly Ching Yu Lam William Bernard Goggins Ka Chun Chong Relationship between acute kidney injury, seasonal influenza, and environmental factors: A 14-year retrospective analysis Environment International Acute kidney injury Seasonal influenza Ambient temperature Air pollution Distributed-lag non-linear model Subtropics |
| title | Relationship between acute kidney injury, seasonal influenza, and environmental factors: A 14-year retrospective analysis |
| title_full | Relationship between acute kidney injury, seasonal influenza, and environmental factors: A 14-year retrospective analysis |
| title_fullStr | Relationship between acute kidney injury, seasonal influenza, and environmental factors: A 14-year retrospective analysis |
| title_full_unstemmed | Relationship between acute kidney injury, seasonal influenza, and environmental factors: A 14-year retrospective analysis |
| title_short | Relationship between acute kidney injury, seasonal influenza, and environmental factors: A 14-year retrospective analysis |
| title_sort | relationship between acute kidney injury seasonal influenza and environmental factors a 14 year retrospective analysis |
| topic | Acute kidney injury Seasonal influenza Ambient temperature Air pollution Distributed-lag non-linear model Subtropics |
| url | http://www.sciencedirect.com/science/article/pii/S016041202100146X |
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