Carbopol Based Hydrogels for ITOPRIDE Hydrochloride Delivery; Synthesis, Characterization and Comparative Assessment with Various Monomers
The objective of the current study was to synthesize and characterize carbopol containing hydrogels with different monomers such as methacrylic acid (MAA), 2-acrylamido-2-methylpropane sulfonic acid (AMPS) and itaconic acid (ITA). Free radical polymerization method was optimized for the preparation...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/13/4/295 |
| _version_ | 1797456982595076096 |
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| author | Muhammad Sarfraz Rabia Iqbal Kifayat Ullah Khan Muhammad Usman Minhas |
| author_facet | Muhammad Sarfraz Rabia Iqbal Kifayat Ullah Khan Muhammad Usman Minhas |
| author_sort | Muhammad Sarfraz |
| collection | DOAJ |
| description | The objective of the current study was to synthesize and characterize carbopol containing hydrogels with different monomers such as methacrylic acid (MAA), 2-acrylamido-2-methylpropane sulfonic acid (AMPS) and itaconic acid (ITA). Free radical polymerization method was optimized for the preparation of different formulations using <i>N</i>,<i>N</i>-methylene bis-acrylamide (MBA) as cross linking agent. Different studies were performed to evaluate the effect of different monomers on swelling, drug loading and drug release. Itopride Hydrochloride was used as model drug. FTIR, TGA, DSC and SEM were performed to probe the characteristics of fabricated hydrogels. Swelling studies of different fabricated hydrogels were performed in three pH conditions (1.2, 4.5 & 6.8). Higher swelling was observed at pH 6.8. An in-vitro release study was performed on pH 1.2 and 6.8. The synthesized hydrogels exhibited excellent mechanical strength, higher drug loading, pH sensitive and time dependent release up to 30 h. The excellent mechanical strength and extended drug release of Carbopol-co-poly-MAA-ITA hydrogels make them a potential candidate for controlled delivery of Itopride hydrochloride. |
| first_indexed | 2024-03-09T16:14:39Z |
| format | Article |
| id | doaj.art-285023376ff6471ab731dd0abecb2a80 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T16:14:39Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-285023376ff6471ab731dd0abecb2a802023-11-24T15:50:59ZengMDPI AGJournal of Functional Biomaterials2079-49832022-12-0113429510.3390/jfb13040295Carbopol Based Hydrogels for ITOPRIDE Hydrochloride Delivery; Synthesis, Characterization and Comparative Assessment with Various MonomersMuhammad Sarfraz0Rabia Iqbal1Kifayat Ullah Khan2Muhammad Usman Minhas3College of Pharmacy, Al Ain University, Al Ain Campus, Al Ain 64141, United Arab EmiratesCollege of Pharmacy, University of Sargodha, Sargodha 40100, Punjab, PakistanQuaide-e-Azam College of Pharmacy, Sahiwal 57000, Punjab, PakistanCollege of Pharmacy, University of Sargodha, Sargodha 40100, Punjab, PakistanThe objective of the current study was to synthesize and characterize carbopol containing hydrogels with different monomers such as methacrylic acid (MAA), 2-acrylamido-2-methylpropane sulfonic acid (AMPS) and itaconic acid (ITA). Free radical polymerization method was optimized for the preparation of different formulations using <i>N</i>,<i>N</i>-methylene bis-acrylamide (MBA) as cross linking agent. Different studies were performed to evaluate the effect of different monomers on swelling, drug loading and drug release. Itopride Hydrochloride was used as model drug. FTIR, TGA, DSC and SEM were performed to probe the characteristics of fabricated hydrogels. Swelling studies of different fabricated hydrogels were performed in three pH conditions (1.2, 4.5 & 6.8). Higher swelling was observed at pH 6.8. An in-vitro release study was performed on pH 1.2 and 6.8. The synthesized hydrogels exhibited excellent mechanical strength, higher drug loading, pH sensitive and time dependent release up to 30 h. The excellent mechanical strength and extended drug release of Carbopol-co-poly-MAA-ITA hydrogels make them a potential candidate for controlled delivery of Itopride hydrochloride.https://www.mdpi.com/2079-4983/13/4/295hydrogelscarbopolitopride hydrochloridecontrolled releaseswelling studies |
| spellingShingle | Muhammad Sarfraz Rabia Iqbal Kifayat Ullah Khan Muhammad Usman Minhas Carbopol Based Hydrogels for ITOPRIDE Hydrochloride Delivery; Synthesis, Characterization and Comparative Assessment with Various Monomers Journal of Functional Biomaterials hydrogels carbopol itopride hydrochloride controlled release swelling studies |
| title | Carbopol Based Hydrogels for ITOPRIDE Hydrochloride Delivery; Synthesis, Characterization and Comparative Assessment with Various Monomers |
| title_full | Carbopol Based Hydrogels for ITOPRIDE Hydrochloride Delivery; Synthesis, Characterization and Comparative Assessment with Various Monomers |
| title_fullStr | Carbopol Based Hydrogels for ITOPRIDE Hydrochloride Delivery; Synthesis, Characterization and Comparative Assessment with Various Monomers |
| title_full_unstemmed | Carbopol Based Hydrogels for ITOPRIDE Hydrochloride Delivery; Synthesis, Characterization and Comparative Assessment with Various Monomers |
| title_short | Carbopol Based Hydrogels for ITOPRIDE Hydrochloride Delivery; Synthesis, Characterization and Comparative Assessment with Various Monomers |
| title_sort | carbopol based hydrogels for itopride hydrochloride delivery synthesis characterization and comparative assessment with various monomers |
| topic | hydrogels carbopol itopride hydrochloride controlled release swelling studies |
| url | https://www.mdpi.com/2079-4983/13/4/295 |
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