Associations between SARS-CoV-2 infection and incidence of new chronic condition diagnoses: a systematic review
ABSTRACTBecause of the large number of infected individuals, an estimate of the future burdens of the long-term consequences of SARS-CoV-2 infection is needed. This systematic review examined associations between SARS-CoV-2 infection and incidence of categories of and selected chronic conditions, by...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
|
| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2204166 |
| _version_ | 1797652781277904896 |
|---|---|
| author | Lindsay A. Gaudet Jennifer Pillay Sabrina Saba Dianne Zakaria Nicholas Cheta Hélène Gardiner Larry Shaver Jacqueline Middleton Maria Tan Ben Vandermeer Lisa Hartling |
| author_facet | Lindsay A. Gaudet Jennifer Pillay Sabrina Saba Dianne Zakaria Nicholas Cheta Hélène Gardiner Larry Shaver Jacqueline Middleton Maria Tan Ben Vandermeer Lisa Hartling |
| author_sort | Lindsay A. Gaudet |
| collection | DOAJ |
| description | ABSTRACTBecause of the large number of infected individuals, an estimate of the future burdens of the long-term consequences of SARS-CoV-2 infection is needed. This systematic review examined associations between SARS-CoV-2 infection and incidence of categories of and selected chronic conditions, by age and severity of infection (inpatient vs. outpatient/mixed care). MEDLINE and EMBASE were searched (1 January 2020 to 4 October 2022) and reference lists scanned. We included observational studies from high-income OECD countries with a control group adjusting for sex and comorbidities. Identified records underwent a two-stage screening process. Two reviewers screened 50% of titles/abstracts, after which DistillerAI acted as second reviewer. Two reviewers then screened the full texts of stage one selections. One reviewer extracted data and assessed risk of bias; results were verified by another. Random-effects meta-analysis estimated pooled hazard ratios (HR). GRADE assessed certainty of the evidence. Twenty-five studies were included. Among the outpatient/mixed SARS-CoV-2 care group, there is high certainty of a small-to-moderate increase (i.e. HR 1.26–1.99) among adults ≥65 years of any cardiovascular condition, and of little-to-no difference (i.e. HR 0.75–1.25) in anxiety disorders for individuals <18, 18–64, and ≥65 years old. Among 18–64 and ≥65 year-olds receiving outpatient/mixed care there are probably (moderate certainty) large increases (i.e. HR ≥2.0) in encephalopathy, interstitial lung disease, and respiratory failure. After SARS-CoV-2 infection, there is probably an increased risk of diagnoses for some chronic conditions; whether the magnitude of risk will remain stable into the future is uncertain. |
| first_indexed | 2024-03-11T16:34:56Z |
| format | Article |
| id | doaj.art-28529edee6f2439da05e42a31483d093 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-03-11T16:34:56Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-28529edee6f2439da05e42a31483d0932023-10-23T17:36:55ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512023-12-0112110.1080/22221751.2023.2204166Associations between SARS-CoV-2 infection and incidence of new chronic condition diagnoses: a systematic reviewLindsay A. Gaudet0Jennifer Pillay1Sabrina Saba2Dianne Zakaria3Nicholas Cheta4Hélène Gardiner5Larry Shaver6Jacqueline Middleton7Maria Tan8Ben Vandermeer9Lisa Hartling10Alberta Research Center for Health Evidence, University of Alberta, Edmonton, AB, CanadaAlberta Research Center for Health Evidence, University of Alberta, Edmonton, AB, CanadaAlberta Research Center for Health Evidence, University of Alberta, Edmonton, AB, CanadaPublic Health Agency of Canada, Ottawa, ON, CanadaPublic Health Agency of Canada, Ottawa, ON, CanadaPublic Health Agency of Canada, Ottawa, ON, CanadaPublic Health Agency of Canada, Ottawa, ON, CanadaPublic Health Agency of Canada, Ottawa, ON, CanadaAlberta Research Center for Health Evidence, University of Alberta, Edmonton, AB, CanadaEpidemiology Coordinating and Research Centre, University of Alberta, Edmonton, AB, CanadaAlberta Research Center for Health Evidence, University of Alberta, Edmonton, AB, CanadaABSTRACTBecause of the large number of infected individuals, an estimate of the future burdens of the long-term consequences of SARS-CoV-2 infection is needed. This systematic review examined associations between SARS-CoV-2 infection and incidence of categories of and selected chronic conditions, by age and severity of infection (inpatient vs. outpatient/mixed care). MEDLINE and EMBASE were searched (1 January 2020 to 4 October 2022) and reference lists scanned. We included observational studies from high-income OECD countries with a control group adjusting for sex and comorbidities. Identified records underwent a two-stage screening process. Two reviewers screened 50% of titles/abstracts, after which DistillerAI acted as second reviewer. Two reviewers then screened the full texts of stage one selections. One reviewer extracted data and assessed risk of bias; results were verified by another. Random-effects meta-analysis estimated pooled hazard ratios (HR). GRADE assessed certainty of the evidence. Twenty-five studies were included. Among the outpatient/mixed SARS-CoV-2 care group, there is high certainty of a small-to-moderate increase (i.e. HR 1.26–1.99) among adults ≥65 years of any cardiovascular condition, and of little-to-no difference (i.e. HR 0.75–1.25) in anxiety disorders for individuals <18, 18–64, and ≥65 years old. Among 18–64 and ≥65 year-olds receiving outpatient/mixed care there are probably (moderate certainty) large increases (i.e. HR ≥2.0) in encephalopathy, interstitial lung disease, and respiratory failure. After SARS-CoV-2 infection, there is probably an increased risk of diagnoses for some chronic conditions; whether the magnitude of risk will remain stable into the future is uncertain.https://www.tandfonline.com/doi/10.1080/22221751.2023.2204166COVID-19SARS-CoV-2incidencechronic conditionssystematic reviewmeta-analysis |
| spellingShingle | Lindsay A. Gaudet Jennifer Pillay Sabrina Saba Dianne Zakaria Nicholas Cheta Hélène Gardiner Larry Shaver Jacqueline Middleton Maria Tan Ben Vandermeer Lisa Hartling Associations between SARS-CoV-2 infection and incidence of new chronic condition diagnoses: a systematic review Emerging Microbes and Infections COVID-19 SARS-CoV-2 incidence chronic conditions systematic review meta-analysis |
| title | Associations between SARS-CoV-2 infection and incidence of new chronic condition diagnoses: a systematic review |
| title_full | Associations between SARS-CoV-2 infection and incidence of new chronic condition diagnoses: a systematic review |
| title_fullStr | Associations between SARS-CoV-2 infection and incidence of new chronic condition diagnoses: a systematic review |
| title_full_unstemmed | Associations between SARS-CoV-2 infection and incidence of new chronic condition diagnoses: a systematic review |
| title_short | Associations between SARS-CoV-2 infection and incidence of new chronic condition diagnoses: a systematic review |
| title_sort | associations between sars cov 2 infection and incidence of new chronic condition diagnoses a systematic review |
| topic | COVID-19 SARS-CoV-2 incidence chronic conditions systematic review meta-analysis |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2204166 |
| work_keys_str_mv | AT lindsayagaudet associationsbetweensarscov2infectionandincidenceofnewchronicconditiondiagnosesasystematicreview AT jenniferpillay associationsbetweensarscov2infectionandincidenceofnewchronicconditiondiagnosesasystematicreview AT sabrinasaba associationsbetweensarscov2infectionandincidenceofnewchronicconditiondiagnosesasystematicreview AT diannezakaria associationsbetweensarscov2infectionandincidenceofnewchronicconditiondiagnosesasystematicreview AT nicholascheta associationsbetweensarscov2infectionandincidenceofnewchronicconditiondiagnosesasystematicreview AT helenegardiner associationsbetweensarscov2infectionandincidenceofnewchronicconditiondiagnosesasystematicreview AT larryshaver associationsbetweensarscov2infectionandincidenceofnewchronicconditiondiagnosesasystematicreview AT jacquelinemiddleton associationsbetweensarscov2infectionandincidenceofnewchronicconditiondiagnosesasystematicreview AT mariatan associationsbetweensarscov2infectionandincidenceofnewchronicconditiondiagnosesasystematicreview AT benvandermeer associationsbetweensarscov2infectionandincidenceofnewchronicconditiondiagnosesasystematicreview AT lisahartling associationsbetweensarscov2infectionandincidenceofnewchronicconditiondiagnosesasystematicreview |